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Volume 12 Issue 3
May  2021
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AI Shanshan, HE Aibin. Advances in Basic Research of Congenital Heart Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(3): 291-297. DOI: 10.12290/xhyxzz.2021-0055
Citation: AI Shanshan, HE Aibin. Advances in Basic Research of Congenital Heart Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(3): 291-297. DOI: 10.12290/xhyxzz.2021-0055
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Advances in Basic Research of Congenital Heart Disease

  • 1.

    Department of Physiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China

  • 2.

    Institute of Molecular Medicine, Peking University, Beijing 100871, China

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  • Corresponding author:

    AI Shanshan  Tel: 86-20-61648603, E-mail: aishanshan233@smu.edu.cn

  • Received Date: January 16, 2021
  • Accepted Date: March 22, 2021
  • Issue Publish Date: May 29, 2021
    Graphical Abstract
    • Abstract
  • Congenital heart diseases (CHD) are the most common birth defects worldwide. The etiology of CHD is multifactorial and intricate. Cardiac transcription factors, developmental genes and key molecules of signaling pathways required for early cardiac morphogenesis have been extensively studied in human CHD. Due to the complex etiology, the causes for most of the CHD cases are far from known. A better knowledge of the molecular mechanisms of CHD would enable us to improve intervening strategies and treatment. This review discusses the current progress in the study of the genetics, epigenetic mechanisms, and maternal nutrition underlying CHD, as well as their potential interactions. Besides, we also review the current in vivo/vitro genetic CHD models that can be used for better understanding of the molecular basis underlying CHD, hoping to provide novel therapeutic strategies for clinic treatment.
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    • References (51)
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