Volume 8 Issue 2-3
Oct.  2020
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Qi-pu WANG, Lan ZHU. Genetic Study of Pelvic Organ Prolapse[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(2-3): 178-182. doi: 10.3969/j.issn.1674-9081.2017.03.017
Citation: Qi-pu WANG, Lan ZHU. Genetic Study of Pelvic Organ Prolapse[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(2-3): 178-182. doi: 10.3969/j.issn.1674-9081.2017.03.017

Genetic Study of Pelvic Organ Prolapse

doi: 10.3969/j.issn.1674-9081.2017.03.017
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  • Corresponding author: ZHU Lan   Tel: 010-69155016, Email:zhu_julie@vip.sina.com
  • Received Date: 2016-12-19
  • Publish Date: 2020-10-30
  • Pelvic organ prolapse (POP) is a common disease in middle-aged and old women. Both genetic and environmental factors contribute to the development of POP.Predisposing hereditary factor is an important risk factor for POP. The latest progress of genetic research in POP will be discussed in this article. Most studies focused on genes involved in the synthesis and degradation of connective tissue.The genetics of POP remain to be further explored since no definitive conclusions have been reached so far.

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  • [1] 朱兰.盆腔器官脱垂的中国诊治指南(草案)[J].中华妇产科杂志, 2014, 49:647-651. doi:  10.3760/cma.j.issn.0529-567x.2014.09.002
    [2] Committee on Practice Bulletins-Gynecology A. Practice Bulletin No. 176: Pelvic organ prolapse[J]. Obstet Gynecol, 2017, 129: e56-e72.
    [3] Barber MD, Maher C. Epidemiology and outcome assessment of pelvic organ prolapse[J]. Int Urogynecol J, 2013, 24:1783-1790. doi:  10.1007/s00192-013-2169-9
    [4] Nygaard I, Barber MD, Burgio KL, et al. Prevalence of symptomatic pelvic floor disorders in US women[J]. JAMA, 2008, 300:1311-1316. doi:  10.1001/jama.300.11.1311
    [5] Samuelsson EC, Victor FT, Tibblin G, et al. Signs of genital prolapse in a Swedish population of women 20 to 59 years of age and possible related factors[J]. Am J Obstet Gynecol, 1999, 180:299-305. doi:  10.1016/S0002-9378(99)70203-6
    [6] Hendrix SL, Clark A, Nygaard I, et al. Pelvic organ prolapse in the Women's Health Initiative:gravity and gravidity[J]. Am J Obstet Gynecol, 2002, 186:1160-1166. doi:  10.1067/mob.2002.123819
    [7] Swift S, Woodman P, O'Boyle A, et al. Pelvic Organ Support Study (POSST):the distribution, clinical definition, and epidemiologic condition of pelvic organ support defects[J]. Am J Obstet Gynecol, 2005, 192:795-806. doi:  10.1016/j.ajog.2004.10.602
    [8] Kim CM, Jeon MJ, Chung DJ, et al. Risk factors for pelvic organ prolapse[J]. Int J Gynaecol Obstet, 2007, 98:248-251. doi:  10.1016/j.ijgo.2007.02.019
    [9] Lince SL, van Kempen LC, Vierhout ME, et al. A systematic review of clinical studies on hereditary factors in pelvic organ prolapse[J]. Int Urogynecol J, 2012, 23:1327-1336. doi:  10.1007/s00192-012-1704-4
    [10] Altman D, Forsman M, Falconer C, et al. Genetic influence on stress urinary incontinence and pelvic organ prolapse[J]. Eur Urol, 2008, 54:918-923. doi:  10.1016/j.eururo.2007.12.004
    [11] Buchsbaum GM, Duecy EE, Kerr LA, et al. Pelvic organ prolapse in nulliparous women and their paroussisters[J]. Obstet Gynecol, 2006, 108:1388-1393. doi:  10.1097/01.AOG.0000245784.31082.ed
    [12] Jack GS, Nikolova G, Vilain E, et al. Familial tranmission of genitovaginal prolapse[J]. Int Urogynecol J, 2006, 17:498-501. doi:  10.1007/s00192-005-0054-x
    [13] McLennan MT, Harris JK, Kariuki B, et al. Family history as a risk factor for pelvic organ prolapse[J]. Int Urogynecol J, 2008, 19:1063-1069. doi:  10.1007/s00192-008-0591-1
    [14] Chiaffarino F, Chatenoud L, Dindelli M, et al. Reproductive factors, family history, occupation and risk of urogenital prolapse[J]. Eur J Obstet Gynecol Reprod Biol, 1999, 82:63-67. doi:  10.1016/S0301-2115(98)00175-4
    [15] Rinne KM, Kirkinen PP. What predisposes young women to genital prolapse?[J]. Eur J Obstet Gynecol ReprodBiol, 1999, 84:23-25. doi:  10.1016/S0301-2115(99)00002-0
    [16] Rao S, Lang J, Zhu L, et al. Exome sequencing identifies a novel gene, WNK1, for susceptibility to pelvic organ prolapse (POP)[J]. PLoS One, 2015, 10:e0119482. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=Doaj000004555694
    [17] Allen-Brady K, Cannon-Albright L, Farnham JM, et al. Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis[J]. Obstet Gynecol, 2011, 118:1345. doi:  10.1097/AOG.0b013e318236f4b5
    [18] Giri A, Wu JM, Ward RM, et al. Genetic determinants of pelvic organ prolapse among African American and hispanic women in the women's health initiative[J]. PLoS One, 2015, 10:e0141647. doi:  10.1371/journal.pone.0141647
    [19] Nikolova G, Lee H, Berkovitz S, et al. Sequence variant in the laminin γ1(LAMC1) gene associated with familial pelvic organ prolapse[J]. Hum Genet, 2007, 120:847-856. doi:  10.1007/s00439-006-0267-1
    [20] Allen-Brady K, Norton PA, Farnham JM, et al. Significant linkage evidence for a predisposition gene for pelvic floor disorders on chromosome 9q21[J]. Am J Hum Genet, 2009, 84:678-682. doi:  10.1016/j.ajhg.2009.04.002
    [21] Khadzhieva MB, Kolobkov DS, Kamoeva SV, et al. Verification of the chromosome region 9q21 association with pelvic organ prolapse using RegulomeDBannotations[J]. Biomed Res Int, 2015, 2015:837904.
    [22] Allen-Brady K, Cannon-Albright LA, Farnham JM, et al. Evidence for pelvic organ prolapse predisposition genes on chromosomes 10 and 17[J]. Am J Obstet Gynecol, 2015, 212:771.e1-e7. doi:  10.1016/j.ajog.2014.12.037
    [23] 李蕾, 朱兰.盆腔器官脱垂相关遗传学的研究进展[J].中国医学杂志, 2016, 96:398-400. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zhyx201605020
    [24] Chen HY, Chung YW, Lin WY, et al. Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse[J]. Int J Gynaecol Obstet, 2008, 103:55-58. doi:  10.1016/j.ijgo.2008.05.031
    [25] Kluivers KB, Dijkstra JR, Hendriks JC, et al. COL3A12209G>A is a predictor of pelvic organ prolapse[J].Int Urogynecol J, 2009, 20:1113-1118. doi:  10.1007/s00192-009-0913-y
    [26] Lince SL, van Kempen LC, Dijkstra JR, et al. Collagen type Ⅲ alpha 1 polymorphism (rs1800255, COL3A12209 G>A) assessed with high-resolution melting analysis is not associated with pelvic organ prolapse in the Dutch population[J].Int Urogynecol J, 2014, 25:1237-1242. doi:  10.1007/s00192-014-2385-y
    [27] Jeon MJ, Chung SM, Choi JR, et al. The relationship between COL3A1 exon 31 polymorphism and pelvic organ prolapse[J]. J Urol, 2009, 181:1213-1216. doi:  10.1016/j.juro.2008.11.027
    [28] Martins Kde F, de Jármy-DiBella ZI, da Fonseca AM, et al. Evaluation of demographic, clinical characteristics, and genetic polymorphism as risk factors for pelvic organ prolapse in Brazilian women[J]. Neurourol Urodyn, 2011, 30:1325-1328. doi:  10.1002/nau.21066
    [29] Feiner B, Fares F, Azam N, et al. Does COLIA1 SP1-binding site polymorphism predispose women to pelvic organ prolapse?[J]. Int Urogynecol J, 2009, 20:1061-1065. doi:  10.1007/s00192-009-0895-9
    [30] Cho HJ, Jung HJ, Kim SK, et al. Polymorphism of a COLIA1 gene Sp1 binding site in Korean women with pelvic organ prolapse[J]. Yonsei Med J, 2009, 50:564-568. doi:  10.3349/ymj.2009.50.4.564
    [31] Ferrari MM, Rossi G, Biondi ML, et al. Type Ⅰ collagen and matrix metalloproteinase 1, 3 and 9 gene polymorphisms in the predisposition to pelvic organ prolapse[J]. Arch Gynecol Obstet, 2012, 285:1581-1586. doi:  10.1007/s00404-011-2199-9
    [32] Rodrigues AM, Girão MJ, da Silva ID, et al. COL1A1 Sp1-binding site polymorphism as a risk factor for genital prolapse[J]. Int Urogynecol J, 2008, 19:1471-1475. doi:  10.1007/s00192-008-0662-3
    [33] Skorupski P, Miotãa P, Jankiewicz K, et al. Polymorphism of the gene encoding alpha-1 chain of collagen type Ⅰ and a risk of pelvic organ prolapse-a preliminary study[J]. Ginekol Pol, 2007, 78:852-855. https://core.ac.uk/download/pdf/225363038.pdf
    [34] Chen C, Hill LD, Schubert CM, et al. Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse?[J]. Am J Obstet Gynecol, 2010, 202:505.e1-e5. doi:  10.1016/j.ajog.2010.01.014
    [35] Wu JM, Visco AG, Grass EA, et al. Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse[J]. Am J Obstet Gynecol, 2012, 206:447.e1-e6. doi:  10.1016/j.ajog.2012.01.033
    [36] Fu R, Hagstrom SA, Daneshgari F. Mutation screen of lysyl oxidase-like-1 and laminin, gamma 1 variant in patients with advanced female pelvic organ prolapse[J]. J Urol, 2009, 181:481.
    [37] Chen HY, Lin WY, Chen YH, et al. Matrix metalloproteinase-9 polymorphism and risk of pelvic organ prolapse in Taiwanese women[J]. Eur J Obstet Gynecol Reprod Biol, 2010, 149:222-224. doi:  10.1016/j.ejogrb.2009.12.014
    [38] Wu JM, Visco AG, Grass EA, et al. Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organ prolapse[J]. Obstet Gynecol, 2012, 120:587. doi:  10.1097/AOG.0b013e318262234b
    [39] Romero AA, Jamison MG, Weidner AC. Are single nucleotide polymorphisms associated with pelvic organ prolapse?[J]. Female Pelvic Med Reconstr Surg, 2008, 14:37-43.
    [40] Ward RM, Velez Edwards DR, Edwards T, et al. Genetic epidemiology of pelvic organ prolapse:a systematic review[J]. Am J Obstet Gynecol, 2014, 211:326-335. doi:  10.1016/j.ajog.2014.04.006
    [41] Cartwright R, Kirby AC, Tikkinen KA, et al. Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women[J]. Am J Obstet Gynecol, 2015, 212:199.e1-e24. doi:  10.1016/j.ajog.2014.08.005
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