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Volume 12 Issue 2
May  2021
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CHEN Xiao-han, YU Qi. Protective Effect of Estrogen on Infection of Respiratory Virus[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(2): 179-183. DOI: 10.12290/xhyxzz.20200202
Citation: CHEN Xiao-han, YU Qi. Protective Effect of Estrogen on Infection of Respiratory Virus[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(2): 179-183. DOI: 10.12290/xhyxzz.20200202
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Protective Effect of Estrogen on Infection of Respiratory Virus

  • Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds: 

National Key Research and Development Program 2018YFC1002105

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  • Corresponding author:

    YU Qi  Tel: 86-10-69158621, E-mail: yuqimd@163.com

  • Received Date: July 27, 2020
  • Accepted Date: November 09, 2020
  • Available Online: January 03, 2021
  • Issue Publish Date: May 29, 2021
    Graphical Abstract
    • Abstract
  • Estrogen is a multi-functional steroid hormone, which affects not only the female reproductive system, but also endocrine, cardiovascular, and metabolic systems. Estrogen has a potential therapeutic effect on a variety of lung diseases, and estrogen-receptor signaling plays a key role in the innate immunity, adaptive immunity and tissue repair in the course of infection of respiratory virus. Animal experiments have proved that estrogen therapy can reduce inflammatory factors, inhibit inflammatory response, reduce viral titer and so on, so as to improve the survival rate of mice infected with respiratory virus. In this paper, the protective effect of estrogen on the infection of respiratory virus and related mechanisms were reviewed.
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    • References (41)
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