频域光学相干断层扫描观察特发性黄斑裂孔患者脉络膜厚度

陈迪; 李略; 杨治坤; 董方田

doi:10.3969/j.issn.1674-9081.2013.02.006

频域光学相干断层扫描观察特发性黄斑裂孔患者脉络膜厚度

Spectral-domain Optical Coherence Tomography Findings of Choroidal Thickness in Eyes of Patients with Idiopathic Macular Holes

摘要

摘要:
目的研究特发性黄斑裂孔(idiopathic macular holes, IMH)患眼及对侧眼的脉络膜厚度。
方法研究共纳入20例单眼IMH患者及20名性别和年龄相匹配的正常对照者。采用频域光学相干断层扫描深度增强成像技术测量IMH患者患眼、对侧健眼及正常对照眼中心凹下脉络膜厚度(subfoveal choroidal thickness, SFCT)及中心凹鼻侧、颞侧、上方和下方各相距1和2 mm处共9个位点的脉络膜厚度。
结果 IMH患眼组、对侧健眼组及正常对照组的SFCT均值分别为(161.53±50.50)、(204.95±59.58)、(248.00±63.40)μm (P=0.000)。方差分析显示3组间所有位点的脉络膜厚度均值差异均有统计学意义(P < 0.05)。Tukey-Kramer检验多重比较发现IMH患眼组各个位点的脉络膜厚度均值较正常对照组显著降低(P < 0.01), 对侧健眼组在除中心凹上方2 mm及下方2 mm处的脉络膜厚度值以外的7个位点较正常对照组均显著降低(P < 0.05)。
结论 IMH患者患眼的脉络膜厚度明显变薄, 对侧健眼的脉络膜厚度亦有不同程度变薄, 提示IMH的发生与脉络膜的血流灌注状态可能存在一定关系。

Abstract:
Objective To determine the choroidal thickness in the eyes with idiopathic macular hole (IMH) and the unaffected fellow eyes.
Methods Twenty IMH patients and 20 ageand sex-matched healthy controls were recruited. Enhanced depth images were obtained using spectal-domain optical coherence tomography. The choroidal thickness was measured in the subfoveal area and 1 mm and 2 mm away from the fovea in the nasal, temporal, superior and inferior regions.
Results The mean subfoveal area choroidal thickness was (161.53±50.50) μm in the eyes with IMH, (204.95±59.58) μm in the fellow eyes, and (248.00±63.40) μm in the control group (P=0.000). The choroidal thickness at all measured regions showed significant differences among three groups (P < 0.05). Compared with the control group, the choroidal thickness was significantly thinner in eyes with IMH (P < 0.01) and unaffected fellow eyes except for the superior choroidal thickness at 2 mm and inferior choroidal thickness at 2 mm (P < 0.05).
Conclusion Choroidal thickness decreases in eyes with IMH and may also reduce in the unaffected fellow eyes, suggesting that the development of IMH may be associated with the choroid perfusion.

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