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北京协和医院结肠癌专病数据库的建立：单中心数据库经验

Establishment of A Colon Cancer Database at Peking Union Medical College Hospital: A Single-center Database Experience

    摘要
  • 摘要:
      目的  通过整理北京协和医院结肠癌专病数据库建立以来结肠癌患者的临床资料，展示条目信息缺失情况及随访率数据，以期为单中心数据库的建立提供借鉴。
      方法  收集北京协和医院结肠癌专病数据库中2016年1月5日至2022年5月11日期间行手术治疗结肠癌患者的临床资料，包括基本信息、原发灶特征、手术与病理信息及术后并发症等33个条目，计算各条目缺失率和患者随访率。
      结果  共入选符合纳入和排除标准的1682例结肠癌患者。其中男性981例，女性701例；平均年龄(62.75±11.97)岁；术后并发症发生率为15.6%(263/1682)。该数据库包含的条目信息中，患者性别、年龄、民族等基本信息及病理分期信息均登记完全无缺失；而病变部位(12.2%)、免疫组化错配修复状态(8.0%)缺失率相对较高。33个条目的缺失率分布于0~12.2%，其中缺失率＜1%的条目占比81.8%(27/33)，缺失率＜5%的条目占比93.9%(31/33)。随访率方面，完全失访的患者仅占比1.7%，即具备随访信息患者的比例为98.3%；2020年7月2日前入组患者(由于数据库迁移的原因，该日期后入组的患者不具有统一格式的定期随访信息)的第1、2、3、4、5年随访率分别为55.02%、70.96%、72.02%、65.42%、70.91%，2年完全随访率为19.5%。
      结论  北京协和医院结肠癌专病数据库条目缺失率较低，几乎所有患者均具有随访信息，整体数据质量较高，具有一定参考价值，但连续随访率仍存在较大的提升空间。

     

    Abstract:
      Objective  By collecting the patient information in the Colon Cancer Database of Peking Union Medical College Hospital since its establishment, we aim to demonstrate the completeness of the clinicopathological characteristics and follow-up data to provide reference for single-center database establishment.
      Methods  We collected 33 surgical patient information entries from the single-center prospective registry database of Colon Cancer at Peking Union Medical College Hospital from January 5, 2016 to May 11, 2022, including demographic characteristics, features of the primary lesion, surgical and pathological information and postoperative complications, and calculated the missing rate of each entry as well as the follow-up data.
      Results  A total of 1682 patients with colon cancer were included in the analysis, in which 981 patients were male and 701 patients were female, with an average age of (62.75±11.97) years. The postoperative complication rate was 15.6% (263/1682). Among the data entries, demographic features such as sex, age, ethnic group as well as the pathologic staging were collected without missing. The relatively high-missing entries were the colonoscopy tumor site with a missing rate of 12.2%, followed by immunohistochemical information of mismatch repair with a missing rate of 8.0%. The missing rate of all 33 entries was distributed in 0-12.2%, of which 81.8% (27/33) were less than 1% and 93.9% (31/33) were less than 5%. As for follow-up data, the percentage of patients with complete missing follow-up was 1.7%, which meant 98.3% patients had available survival data. The 1-year, 2-year, 3-year, 4-year and 5-year follow-up rates of patients enrolled before July 2, 2020 (patients enrolled after this date did not have regular follow-up information in a uniform format due to data migration) were 55.02%, 70.96%, 72.02%, 65.42% and 70.91%, respectively, and the 2-year complete follow-up rate was 19.5%.
      Conclusion  The low rate of missing statistical entries and the high follow-up rate of our center's database has certain reference value for database establishment, but there is still room for improvement in terms of continuous follow-up.

     

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