Abstract: Obesity has become a global "epidemic".At this stage, overweight/obesity has become a major public health problem that seriously affects the physical and mental health of Chinese people. Medical nutritional therapy is the basic treatment for obesity and an indispensable measure for prevention and control at any stage in the course of obesity.In December 2021, the Chinese Guidelines on Medical Nutritional Therapy for Overweight/Obesity (2021) was published, which covers the relationship of weight loss with different dietary patterns, meal replacement foods, biorhythms, intestinal microecology, metabolic surgery, and medical nutritional intervention, as well as weight loss in special populations. With a view to providing clinical reference for the standardized treatment and management of overweight/obesity, this paper makes a detailed interpretation of the key points of the guidelines.