Abstract: Psoriasis is a kind of chronic recurrent disease, which is easy to recur and protract. It has a severe impact on the life quality of patients. There are multiple factors for the relapse of psoriasis, such as stress, environment, life-style, endocrine and so on. The immunological mechanism of the recurrence of psoriasis is complex. Tissue-resident memory T cells (T_RM) may play an important role in the immunological memory of psoriasis. To define the risk factors and the potential pathogenesis of the recurrence of psoriasis can provide basis for the clinical prevention of recurrence and aggravation of psoriasis. To block the function of T_RM might open new avenues for preventing the recurrence of psoriasis.