Rui ZHANG, Yan BAI, Wei WEI, Mei-yun WANG. Application of Magnetic Resonance-guided Focused Ultrasound Therapy in Central Nervous System Diseases[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(1): 54-61. DOI: 10.3969/j.issn.1674-9081.20190214
Citation: Rui ZHANG, Yan BAI, Wei WEI, Mei-yun WANG. Application of Magnetic Resonance-guided Focused Ultrasound Therapy in Central Nervous System Diseases[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(1): 54-61. DOI: 10.3969/j.issn.1674-9081.20190214

Application of Magnetic Resonance-guided Focused Ultrasound Therapy in Central Nervous System Diseases

More Information
  • Corresponding author:

    WANG Mei-yun Tel: 86-371-65580013, E-mail:marian9999@163.com

  • Received Date: October 07, 2019
  • Issue Publish Date: January 29, 2020
  • Magnetic resonance-guided focused ultrasound is an advanced non-invasive therapeutic technique, which has great potential in targeted thermal ablation and blood-brain barrier opening treatment of central nervous system diseases. It has been used in the research and treatment of essential tremor, Parkinson's disease, intracranial tumors, Alzheimer's disease, obsessive-compulsive disorder, neuropathic pain, and other diseases now. Magnetic resonance-guided focused ultrasound therapy may be a potential alternative therapy for many diseases due to its advantages such as precision, non-ionizing radiation, and real-time monitoring of target temperature. In this article, we reviewed the progress of magnetic resonance-guided focused ultrasound therapy in clinical applications and scientific researches.
  • [1]
    Kobus T, McDannold N. Update on Clinical Magnetic Resonance-Guided Focused Ultrasound Applications[J]. Magn Reson Imaging Clin N Am, 2015, 23:657-667. DOI: 10.1016/j.mric.2015.05.013
    [2]
    金征宇, 苏佰燕, 薛华丹.磁共振引导下聚焦超声新技术进展及其临床应用[J].磁共振成像, 2014, 5:26-30. http://www.cnki.com.cn/Article/CJFDTotal-CGZC2014S1008.htm
    [3]
    苏佰燕, 薛华丹, 金征宇.子宫肌瘤的影像诊断及与影像医学相关的治疗[J].协和医学杂志, 2011, 2:273-276. http://d.wanfangdata.com.cn/Periodical/xhyx201103017
    [4]
    Meng Y, Suppiah S, Mithani K, et al. Current and emerging brain applications of MR-guided focused ultrasound[J]. J Ther Ultrasound, 2017, 5:26. DOI: 10.1186/s40349-017-0105-z
    [5]
    Louis ED, Ferreira JJ. How common is the most common adult movement disorder:update on the worldwide prevalence of essential tremor[J]. Mov Disord, 2010, 25:534-541. DOI: 10.1002/mds.22838
    [6]
    Chandran V, Pal PK, Reddy JYC, et al. Non-motor features in essential tremor[J]. Acta Neurol Scand, 2012, 125:332-337. DOI: 10.1111/j.1600-0404.2011.01573.x
    [7]
    Lundervold DA, Ament PA, Holt P. Social anxiety, tremor severity, and tremor disability:a search for clinically relevant measures[J]. Psychiatry J, 2013, 2013:257459. DOI: 10.1155/2013/257459
    [8]
    Lorenz D, Poremba C, Papengut F, et al. The psychosocial burden of essential tremor in an outpatient-and a community-based cohort[J]. Eur J Neurol, 2011, 18:972-979. DOI: 10.1111/j.1468-1331.2010.03295.x
    [9]
    毛成洁, 陈菊萍, 胡伟东, 等.运动障碍疾病伴发抑郁的临床观察[J].中华医学杂志, 2013, 93:26-29. http://www.cqvip.com/QK/93850X/201301/44534208.html
    [10]
    Haubenberger D, Hallett M. Essential Tremor[J]. N Engl J Med, 2018, 378:1802-1810. DOI: 10.1056/NEJMcp1707928
    [11]
    Elias WJ, Shah BB. Tremor[J]. JAMA, 2014, 311:948-954. DOI: 10.1001/jama.2014.1397
    [12]
    Elias WJ, Khaled M, Hilliard JD, et al. A magnetic resonance imaging, histological, and dose modeling comparison of focused ultrasound radiofrequency, and Gamma Knife radiosurgery lesions in swine thalamus[J]. J Neurosurg, 2013, 119:307-317. DOI: 10.3171/2013.5.JNS122327
    [13]
    Shanker V. Essential tremor:diagnosis and management.[J]. BMJ, 2019, 366:l4485. https://pubmed.ncbi.nlm.nih.gov/31383632/
    [14]
    Elias WJ, Huss D, Voss T, et al. A pilot study of focused ultrasound thalamotomy for essential tremor[J]. N Engl J Med, 2013, 369:640-648. DOI: 10.1056/NEJMoa1300962
    [15]
    Lipsman N, Schwartz ML, Huang Y, et al. MR-guided focused ultrasound thalamotomy for essential tremor:a proof-of-concept study[J]. Lancet Neurol, 2013, 12:462-468. DOI: 10.1016/S1474-4422(13)70048-6
    [16]
    Chang WS, Jung HH, Kweon EJ, et al. Unilateral magnetic resonance guided focused ultrasound thalamotomy for essential tremor:practices and clinicoradiological outcomes[J]. J Neurol Neurosurg Psychiatry, 2015, 86:257-264. DOI: 10.1136/jnnp-2014-307642
    [17]
    Elias WJ, Lipsman N, Ondo WG, et al. A randomized trial of focused ultrasound thalamotomy for essential tremor[J]. N Engl J Med, 2016, 375:730-739. DOI: 10.1056/NEJMoa1600159
    [18]
    Fishman PS. Thalamotomy for essential tremor:FDA approval brings brain treatment with FUS to the clinic[J]. J Ther Ultrasound, 2017, 5:19. DOI: 10.1186/s40349-017-0096-9
    [19]
    Iacopino DG, Gagliardo C, Giugno A, et al. Preliminary experience with a transcranial magnetic resonance-guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson's disease[J]. Neurosurg Focus, 2018, 44:E7. http://www.ncbi.nlm.nih.gov/pubmed/29385927
    [20]
    Jung NY, Park CK, Chang WS, et al. Effects on cognition and quality of life with unilateral magnetic resonance-guided focused ultrasound thalamotomy for essential tremor[J]. Neurosurg Focus, 2018, 44:E8. https://pubmed.ncbi.nlm.nih.gov/29385928/
    [21]
    Zaaroor M, Sinai A, Goldsher D, et al. Magnetic resonance-guided focused ultrasound thalamotomy for tremor:a report of 30 Parkinson's disease and essential tremor cases[J]. J Neurosurg, 2018, 128:202-210. DOI: 10.3171/2016.10.JNS16758
    [22]
    宗睿, 何建风, 张德康, 等.磁共振引导超声聚焦系统("磁波刀")在治疗特发性震颤中的应用[J].解放军医学院学报, 2019, 40:1-6. http://www.cqvip.com/Main/Detail.aspx?id=74897488504849574849484850
    [23]
    Fishman PS, Elias WJ, Ghanouni P, et al. Neurological adverse event profile of magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor[J]. Mov Disord, 2018, 33:843-847. DOI: 10.1002/mds.27401
    [24]
    Chang JW, Park CK, Lipsman N, et al. A prospective trial of magnetic resonance-guided focused ultrasound thalamo-tomy for essential tremor:Results at the 2-year follow-up[J]. Ann Neurol, 2018, 83:107-114. DOI: 10.1002/ana.25126
    [25]
    Sinai A, Nassar M, Eran A, et al. Magnetic resonance-guided focused ultrasound thalamotomy for essential tremor:a 5-year single-center experience[J]. J Neurosurg, 2019, 1:1-8. http://www.researchgate.net/publication/339290667_Erratum_Magnetic_resonance-guided_focused_ultrasound_thalamotomy_for_essential_tremor_a_5-year_single-center_experience
    [26]
    Schlesinger I, Eran A, Sinai A, et al. MRI guided focused ultrasound thalamotomy for moderate-to-severe tremor in Parkinson's disease[J]. Parkinsons Dis, 2015, 2015:219149. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572440/
    [27]
    Bond AE, Shah BB, Huss DS, et al. Safety and efficacy of focused ultrasound thalamotomy for patients with medication-refractory, tremor-dominant Parkinson disease:a randomized clinical trial[J]. JAMA Neurol, 2017, 74:1412-1418. DOI: 10.1001/jamaneurol.2017.3098
    [28]
    Fasano A, Llinas M, Munhoz RP, et al. MRI-guided focused ultrasound thalamotomy in non-ET tremor syndromes[J]. Neurology, 2017, 89:771-775. DOI: 10.1212/WNL.0000000000004268
    [29]
    史俊庭, 崔冰心.河南完成大陆地区首例帕金森病震颤磁波刀治疗[EB/OL]. http://news.sciencenet.cn/htmlnews/2019/3/423392.shtm.
    [30]
    Magara A, Bühler R, Moser D, et al. First experience with MR-guided focused ultrasound in the treatment of Parkinson's disease[J]. J Ther Ultrasound, 2014, 2:11. DOI: 10.1186/2050-5736-2-11
    [31]
    Na YC, Chang WS, Jung HH, et al. Unilateral magnetic resonance-guided focused ultrasound pallidotomy for Parkinson disease[J]. Neurology, 2015, 85:549-551. DOI: 10.1212/WNL.0000000000001826
    [32]
    Jung NY, Park CK, Kim M, et al. The efficacy and limits of magnetic resonance-guided focused ultrasound pallidotomy for Parkinson's disease:a Phase I clinical trial[J]. J Neurosurg, 2018, 1:1-9. https://thejns.org/downloadpdf/journals/j-neurosurg/130/6/article-p1853.xml
    [33]
    Martínez-Fernández R, Rodríguez-Rojas R, del Álamo M, et al. Focused ultrasound subthalamotomy in patients with asymmetric Parkinson's disease:a pilot study[J]. Lancet Neurol, 2018, 17:54-63. DOI: 10.1016/S1474-4422(17)30403-9
    [34]
    Yang FY, Horng SC. Ultrasound enhanced delivery of macromolecular agents in brain tumor rat model[C]. 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2011: 5573-5576.
    [35]
    Burgess A, Hynynen K. Noninvasive and targeted drug delivery to the brain using focused ultrasound[J]. ACS Chem Neurosci, 2013, 4:519-526. DOI: 10.1021/cn300191b
    [36]
    Fan CH, Ting CY, Lin CY, et al. Noninvasive, targeted, and non-viral ultrasound-mediated GDNF-plasmid delivery for treatment of Parkinson's disease[J]. Sci Rep, 2016, 6:19579. DOI: 10.1038/srep19579
    [37]
    Mead BP, Kim N, Miller GW, et al. Novel focused ultrasound gene therapy approach noninvasively restores dopaminergic neuron function in a rat Parkinson's disease model[J]. Nano Lett, 2017, 17:3533-3542. DOI: 10.1021/acs.nanolett.7b00616
    [38]
    Meng Y, Voisin MR, Suppiah S, et al. Is there a role for MR-guided focused ultrasound in Parkinson's disease?[J]. Mov Disord, 2018, 33:575-579. DOI: 10.1002/mds.27308
    [39]
    Mainprize T, Lipsman N, Huang Y, et al. Blood-brain barrier opening in primary brain tumors with non-invasive MR-guided focused ultrasound:a clinical safety and feasibility study[J]. Sci Rep, 2019, 9:321. DOI: 10.1038/s41598-018-36340-0
    [40]
    Rochet NM, Dronca RS, Kottschade LA, et al. Melanoma brain metastases and vemurafenib:need for further investigation[J]. Mayo Clin Proc, 2012, 87:976-981. DOI: 10.1016/j.mayocp.2012.07.006
    [41]
    Wei KC, Chu PC, Wang HYJ, et al. Focused ultrasound-induced blood-brain barrier opening to enhance temozolomide delivery for glioblastoma treatment:a preclinical study[J]. PLoS One, 2013, 8:e58995. DOI: 10.1371/journal.pone.0058995
    [42]
    Kobus T, Zervantonakis IK, Zhang Y, et al. Growth inhibition in a brain metastasis model by antibody delivery using focused ultrasound-mediated blood-brain barrier disruption[J]. J Control Release, 2016, 238:281-288. DOI: 10.1016/j.jconrel.2016.08.001
    [43]
    Treat LH, McDannold N, Zhang Y, et al. Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma[J]. Ultrasound Med Biol, 2012, 38:1716-1725. DOI: 10.1016/j.ultrasmedbio.2012.04.015
    [44]
    Alli S, Figueiredo CA, Golbourn B, et al. Brainstem blood brain barrier disruption using focused ultrasound:A demonstration of feasibility and enhanced doxorubicin delivery[J]. J Control Release, 2018, 281:29-41. DOI: 10.1016/j.jconrel.2018.05.005
    [45]
    Carpentier A, Canney M, Vignot A, et al. Clinical trial of blood-brain barrier disruption by pulsed ultrasound[J]. Sci Transl Med, 2016, 8:343re2. DOI: 10.1126/scitranslmed.aaf6086
    [46]
    Idbaih A, Canney M, Belin L, et al. Safety and feasibility of repeated and transient blood-brain barrier disruption by pulsed ultrasound in patients with recurrent glioblastoma[J]. Clin Cancer Res, 2019, 25:3793-3801. DOI: 10.1158/1078-0432.CCR-18-3643
    [47]
    Meng Y, Suppiah S, Surendrakumar S, et al. Low-intensity MR-guided focused ultrasound mediated disruption of the blood-brain barrier for intracranial metastatic diseases[J]. Front Oncol, 2018, 8:338. DOI: 10.3389/fonc.2018.00338
    [48]
    McDannold N, Clement GT, Black P, et al. Transcranial magnetic resonance imaging-guided focused ultrasound surgery of brain tumors:initial findings in 3 patients[J]. Neurosurgery, 2010, 66:323-332. DOI: 10.1227/01.NEU.0000360379.95800.2F
    [49]
    Coluccia D, Fandino J, Schwyzer L, et al. First noninvasive thermal ablation of a brain tumor with MR-guided focused ultrasound[J]. J Ther Ultrasound, 2014, 2:17. DOI: 10.1186/2050-5736-2-17
    [50]
    Karakatsani ME, Kugelman T, Ji R, et al. Unilateral focused ultrasound-induced blood-brain barrier opening reduces phosphorylated tau from the rTg4510 mouse model[J]. Theranostics, 2019, 9:5396-5411. DOI: 10.7150/thno.28717
    [51]
    Nisbet RM, Van der Jeugd A, Leinenga G, et al. Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model[J]. Brain, 2017, 140:1220-1230. DOI: 10.1093/brain/awx052
    [52]
    Jordão JF, Ayala-Grosso CA, Markham K, et al. Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-β plaque load in the TgCRND8 mouse model of Alzheimer's disease[J]. PLoS One, 2010, 5:e10549. DOI: 10.1371/journal.pone.0010549
    [53]
    Burgess A, Dubey S, Yeung S, et al. Alzheimer disease in a mouse model:MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior[J]. Radiology, 2014, 273:736-745. DOI: 10.1148/radiol.14140245
    [54]
    Leinenga G, Götz J. Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model[J]. Sci Transl Med, 2015, 7:278ra33. DOI: 10.1126/scitranslmed.aaa2512
    [55]
    Li L, Xu B, Zhu Y, et al. DHEA prevents Aβ25-35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling[J]. Neuropharmacology, 2010, 59:323-333. DOI: 10.1016/j.neuropharm.2010.02.009
    [56]
    Jalali S, Huang Y, Dumont DJ, et al. Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT:experimental study in rats[J]. BMC Neurol, 2010, 10:114. DOI: 10.1186/1471-2377-10-114
    [57]
    Chen KT, Wei KC, Liu HL. Theranostic strategy of focused ultrasound induced blood-brain barrier opening for CNS disease treatment[J]. Front Pharmacol, 2019, 10:86. DOI: 10.3389/fphar.2019.00086
    [58]
    Lipsman N, Meng Y, Bethune AJ, et al. Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound[J]. Nat Commun, 2018, 9:2336. DOI: 10.1038/s41467-018-04529-6
    [59]
    Meng Y, MacIntosh BJ, Shirzadi Z, et al. Resting state functional connectivity changes after MR-guided focused ultrasound mediated blood-brain barrier opening in patients with Alzheimer's disease[J]. Neuroimage, 2019, 200:275-280. DOI: 10.1016/j.neuroimage.2019.06.060
    [60]
    Hawken E, Dilkov D, Kaludiev E, et al. Transcranial magnetic stimulation of the supplementary motor area in the treatment of obsessive-compulsive disorder:a multi-site study[J]. Int J Mol Sci, 2016, 17:420. DOI: 10.3390/ijms17030420
    [61]
    Franklin ME, Foa EB. Treatment of obsessive compulsive disorder[J]. Annu Rev Clin Psychol, 2011, 7:229-243. DOI: 10.1146/annurev-clinpsy-032210-104533
    [62]
    Kumar KK, Bhati MT, Ravikumar VK, et al. MR-guided Focused Ultrasound versus Radiofrequency Capsulotomy for Treatment-Refractory Obsessive Compulsive Disorder:A Cost-Effectiveness Threshold Analysis[J]. Front Neurosci, 2019, 13:66. DOI: 10.3389/fnins.2019.00066
    [63]
    Jung HH, Kim SJ, Roh D, et al. Bilateral thermal capsulotomy with MR-guided focused ultrasound for patients with treatment-refractory obsessive-compulsive disorder:a proof-of-concept study[J]. Mol Psychiatry, 2015, 20:1205-1211. DOI: 10.1038/mp.2014.154
    [64]
    Kim SJ, Roh D, Jung HH, et al. A study of novel bilateral thermal capsulotomy with focused ultrasound for treatment-refractory obsessive-compulsive disorder:2-year follow-up[J]. J Psychiatry Neurosci, 2018, 43:327-337. DOI: 10.1503/jpn.170188
    [65]
    Kim M, Kim CH, Jung HH, et al. Treatment of major depressive disorder via magnetic resonance-guided focused ultrasound surgery[J]. Biol Psychiatry, 2018, 83:e17-e18. DOI: 10.1016/j.biopsych.2017.05.008
    [66]
    Toth C, Lander J, Wiebe S. The prevalence and impact of chronic pain with neuropathic pain symptoms in the general population[J]. Pain Med, 2009, 10:918-929. DOI: 10.1111/j.1526-4637.2009.00655.x
    [67]
    Jung NY, Chang JW. Magnetic Resonance-Guided Focused Ultrasound in Neurosurgery:Taking Lessons from the Past to Inform the Future[J]. J Korean Med Sci, 2018, 33:e279. DOI: 10.3346/jkms.2018.33.e279
    [68]
    Lee EJ, Fomenko A, Lozano AM. Magnetic resonance-guided focused ultrasound:current status and future perspectives in thermal ablation and blood-brain barrier opening[J]. J Korean Neurosurg Soc, 2019, 62:10-26. DOI: 10.3340/jkns.2018.0180
    [69]
    Jeanmonod D, Werner B, Morel A, et al. Transcranial magnetic resonance imaging-guided focused ultrasound:noninvasive central lateral thalamotomy for chronic neuropathic pain[J]. Neurosurg Focus, 2012, 32:E1.
    [70]
    Parker WE, Weidman EK, Chazen JL, et al. Magnetic resonance-guided focused ultrasound for ablation of mesial temporal epilepsy circuits:modeling and theoretical feasibility of a novel noninvasive approach[J]. J Neurosurg, 2019, 1:1-8. https://www.ncbi.nlm.nih.gov/pubmed/31200385
    [71]
    Ranjan M, Boutet A, Bhatia S, et al. Neuromodulation beyond neurostimulation for epilepsy:scope for focused ultrasound[J]. Expert Rev Neurother, 2019, 19:937-943. DOI: 10.1080/14737175.2019.1635013
    [72]
    Naor O, Krupa S, Shoham S. Ultrasonic neuromodulation[J]. J Neural Eng, 2016, 13:031003. DOI: 10.1088/1741-2560/13/3/031003

Catalog

    Article Metrics

    Article views (645) PDF downloads (208) Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return
    x Close Forever Close