Email Alert RSS
Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. DOI: 10.3969/j.issn.1674-9081.2011.03.004
Citation: Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. DOI: 10.3969/j.issn.1674-9081.2011.03.004
shu

Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease

    Graphical Abstract
    • Abstract
  •   Objective  To explore the change of olfactory bulb (OB) volume in patients with Alzheimer disease (AD) and assess the value of high-resolution magnetic resonance imaging (MRI) in measuring OB volume.
      Methods  Fourteen AD patients and 25 normal aging volunteers (control group) underwent high-resolution MRI imaging of OB and the OB volume was measured.
      Results  The OB volume in AD patients(32.2±7.7) mm3 was significantly smaller than that in control group(40.6±6.6) mm3(P=0.002). The OB volume in AD patients didn't correlate significantly with their mini-mental state examination (MMSE) scores (P=0.205).
      Conclusions  AD patients show more prominent OB atrophy than normal aging volunteers do, which is in agreement with the pathological findings. High-resolution MRI is valuable in identifying the change of OB volume and therefore might be beneficial for AD diagnosis.
    • FullText(HTML)
  • loading
    • References (14)
    • Related Articles
  • Supplements (0)

Catalog

      /

      DownLoad:  Full-Size Img  PowerPoint
      Return
      Return