Volume 2 Issue 3
Jul.  2011
Turn off MathJax
Article Contents
Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. doi: 10.3969/j.issn.1674-9081.2011.03.004
Citation: Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. doi: 10.3969/j.issn.1674-9081.2011.03.004

Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease

doi: 10.3969/j.issn.1674-9081.2011.03.004
More Information
  • Corresponding author: You Hui Tel: 010-65297440, E-mail:youhuimr77@yahoo.com.cn
  • Received Date: 2011-04-25
  • Publish Date: 2011-07-30
  •   Objective  To explore the change of olfactory bulb (OB) volume in patients with Alzheimer disease (AD) and assess the value of high-resolution magnetic resonance imaging (MRI) in measuring OB volume.  Methods  Fourteen AD patients and 25 normal aging volunteers (control group) underwent high-resolution MRI imaging of OB and the OB volume was measured.  Results  The OB volume in AD patients[(32.2±7.7) mm3] was significantly smaller than that in control group[(40.6±6.6) mm3](P=0.002). The OB volume in AD patients didn't correlate significantly with their mini-mental state examination (MMSE) scores (P=0.205).  Conclusions  AD patients show more prominent OB atrophy than normal aging volunteers do, which is in agreement with the pathological findings. High-resolution MRI is valuable in identifying the change of OB volume and therefore might be beneficial for AD diagnosis.
  • loading
  • [1] Hof PR, Glannakopoulos P, Bouras C. The neuropathological changes associated with normal brain aging[J]. Histol Histopathol, 1996, 11:1075-1088. http://www.ncbi.nlm.nih.gov/pubmed/8930649
    [2] Wesson DW, Levy E, Nixon RA, et al. Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model[J]. J Neurosci, 2010, 13:505-514. http://europepmc.org/articles/PMC2826174/
    [3] Christen-Zaech S, Kraftsik R, Pillevuit O, et al. Early olfactory involvement in Alzheimer's disease[J]. Can J Neurol Sci, 2003, 30:20-25. doi:  10.1017/S0317167100002389
    [4] Attems J, Jellinger KA. Olfactory tau pathology in Alzheimer disease and mild cognitive impairment[J]. Clin Neuropathol, 2006, 25:265-271. http://www.ncbi.nlm.nih.gov/pubmed/17140156
    [5] Attems J, Lintner F, Jellinger KA. Olfactory involvement in aging and Alzheimer's disease:an autopsy study[J]. J Alzheimers Dis, 2005, 7:149-157; discussion 173-180. doi:  10.3233/JAD-2005-7208
    [6] ter Laak HJ, Renkawek K, van Workum FP. The olfactory bulb in Alzheimer disease:a morphologic study of neuron loss, tangles, and senile plaques in relation to olfaction[J]. Alzheimer Dis Assoc Disord, 1994, 8:38-48. doi:  10.1097/00002093-199424003-00005
    [7] McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease:report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease[J]. Neurology, 1984, 34:939-944. doi:  10.1212/WNL.34.7.939
    [8] Handley OJ, Morrison CM, Miles C, et al. ApoE gene and familial risk of Alzheimer's disease as predictors of odour identification in older adults[J]. Neurobiol Aging, 2006, 27:1425-1430. doi:  10.1016/j.neurobiolaging.2005.08.001
    [9] Calhoun-Haney R, Murphy C. Apolipoprotein epsilon4 is associated with more rapid decline in odor identification than in odor threshold or Dementia Rating Scale scores[J]. Brain Cogn, 2005, 58:178-182. doi:  10.1016/j.bandc.2004.10.004
    [10] Velayudhan L, Lovestone S. Smell identification test as a treatment response marker in patients with Alzheimer disease receiving donepezil[J]. J Clin Psychopharmacol, 2009, 29:387-390. doi:  10.1097/JCP.0b013e3181aba5a5
    [11] Wilson RS, Arnold SE, Schneider JA, et al. The relationship between cerebral Alzheimer's disease pathology and odour identification in old age[J]. J Neurol Neurosurg Psychiatry, 2007, 78:30-35. doi:  10.1136/jnnp.2006.099721
    [12] Thomann PA, Dos Santos V, Seidl U, et al. MRI-derived atrophy of the olfactory bulb and tract in mild cognitive impairment and Alzheimer's disease[J]. J Alzheimers Dis, 2009, 17:213-221. doi:  10.3233/JAD-2009-1036
    [13] Gomez-Isla T, Price JL, McKeel DW Jr, et al. Profound loss of layer Ⅱ entorhinal cortex neurons occurs in very mild Alzheimer's disease[J]. J Neurosci, 1996, 16:4491-4500. doi:  10.1523/JNEUROSCI.16-14-04491.1996
    [14] Rodrigue KM, Raz N. Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults[J]. J Neurosci, 2004, 24:956-963. doi:  10.1523/JNEUROSCI.4166-03.2004
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(1)

    Article Metrics

    Article views (203) PDF downloads(4) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return