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Volume 2 Issue 3
Jul.  2011
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Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. DOI: 10.3969/j.issn.1674-9081.2011.03.004
Citation: Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. DOI: 10.3969/j.issn.1674-9081.2011.03.004
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Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease

  • 1.

    Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

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  • Corresponding author:

    You Hui Tel: 010-65297440, E-mail:youhuimr77@yahoo.com.cn

  • Received Date: April 24, 2011
  • Issue Publish Date: July 29, 2011
    Graphical Abstract
    • Abstract
  •   Objective  To explore the change of olfactory bulb (OB) volume in patients with Alzheimer disease (AD) and assess the value of high-resolution magnetic resonance imaging (MRI) in measuring OB volume.
      Methods  Fourteen AD patients and 25 normal aging volunteers (control group) underwent high-resolution MRI imaging of OB and the OB volume was measured.
      Results  The OB volume in AD patients[(32.2±7.7) mm3] was significantly smaller than that in control group[(40.6±6.6) mm3](P=0.002). The OB volume in AD patients didn't correlate significantly with their mini-mental state examination (MMSE) scores (P=0.205).
      Conclusions  AD patients show more prominent OB atrophy than normal aging volunteers do, which is in agreement with the pathological findings. High-resolution MRI is valuable in identifying the change of OB volume and therefore might be beneficial for AD diagnosis.
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    • References (14)
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