Email Alert RSS
Volume 2 Issue 3
Jul.  2011
Turn off MathJax
Article Contents
Abstract
References
Related Articles
Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. DOI: 10.3969/j.issn.1674-9081.2011.03.004
Citation: Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. DOI: 10.3969/j.issn.1674-9081.2011.03.004
shu

Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease

  • 1.

    Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information
  • Corresponding author:

    You Hui Tel: 010-65297440, E-mail:youhuimr77@yahoo.com.cn

  • Received Date: April 24, 2011
  • Issue Publish Date: July 29, 2011
    Graphical Abstract
    • Abstract
  •   Objective  To explore the change of olfactory bulb (OB) volume in patients with Alzheimer disease (AD) and assess the value of high-resolution magnetic resonance imaging (MRI) in measuring OB volume.
      Methods  Fourteen AD patients and 25 normal aging volunteers (control group) underwent high-resolution MRI imaging of OB and the OB volume was measured.
      Results  The OB volume in AD patients[(32.2±7.7) mm3] was significantly smaller than that in control group[(40.6±6.6) mm3](P=0.002). The OB volume in AD patients didn't correlate significantly with their mini-mental state examination (MMSE) scores (P=0.205).
      Conclusions  AD patients show more prominent OB atrophy than normal aging volunteers do, which is in agreement with the pathological findings. High-resolution MRI is valuable in identifying the change of OB volume and therefore might be beneficial for AD diagnosis.
    • FullText(HTML)
    • References (14)
  • [1]
    Hof PR, Glannakopoulos P, Bouras C. The neuropathological changes associated with normal brain aging[J]. Histol Histopathol, 1996, 11:1075-1088. http://www.ncbi.nlm.nih.gov/pubmed/8930649
    [2]
    Wesson DW, Levy E, Nixon RA, et al. Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model[J]. J Neurosci, 2010, 13:505-514. http://europepmc.org/articles/PMC2826174/
    [3]
    Christen-Zaech S, Kraftsik R, Pillevuit O, et al. Early olfactory involvement in Alzheimer's disease[J]. Can J Neurol Sci, 2003, 30:20-25. DOI: 10.1017/S0317167100002389
    [4]
    Attems J, Jellinger KA. Olfactory tau pathology in Alzheimer disease and mild cognitive impairment[J]. Clin Neuropathol, 2006, 25:265-271. http://www.ncbi.nlm.nih.gov/pubmed/17140156
    [5]
    Attems J, Lintner F, Jellinger KA. Olfactory involvement in aging and Alzheimer's disease:an autopsy study[J]. J Alzheimers Dis, 2005, 7:149-157; discussion 173-180. DOI: 10.3233/JAD-2005-7208
    [6]
    ter Laak HJ, Renkawek K, van Workum FP. The olfactory bulb in Alzheimer disease:a morphologic study of neuron loss, tangles, and senile plaques in relation to olfaction[J]. Alzheimer Dis Assoc Disord, 1994, 8:38-48. DOI: 10.1097/00002093-199424003-00005
    [7]
    McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease:report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease[J]. Neurology, 1984, 34:939-944. DOI: 10.1212/WNL.34.7.939
    [8]
    Handley OJ, Morrison CM, Miles C, et al. ApoE gene and familial risk of Alzheimer's disease as predictors of odour identification in older adults[J]. Neurobiol Aging, 2006, 27:1425-1430. DOI: 10.1016/j.neurobiolaging.2005.08.001
    [9]
    Calhoun-Haney R, Murphy C. Apolipoprotein epsilon4 is associated with more rapid decline in odor identification than in odor threshold or Dementia Rating Scale scores[J]. Brain Cogn, 2005, 58:178-182. DOI: 10.1016/j.bandc.2004.10.004
    [10]
    Velayudhan L, Lovestone S. Smell identification test as a treatment response marker in patients with Alzheimer disease receiving donepezil[J]. J Clin Psychopharmacol, 2009, 29:387-390. DOI: 10.1097/JCP.0b013e3181aba5a5
    [11]
    Wilson RS, Arnold SE, Schneider JA, et al. The relationship between cerebral Alzheimer's disease pathology and odour identification in old age[J]. J Neurol Neurosurg Psychiatry, 2007, 78:30-35. DOI: 10.1136/jnnp.2006.099721
    [12]
    Thomann PA, Dos Santos V, Seidl U, et al. MRI-derived atrophy of the olfactory bulb and tract in mild cognitive impairment and Alzheimer's disease[J]. J Alzheimers Dis, 2009, 17:213-221. DOI: 10.3233/JAD-2009-1036
    [13]
    Gomez-Isla T, Price JL, McKeel DW Jr, et al. Profound loss of layer Ⅱ entorhinal cortex neurons occurs in very mild Alzheimer's disease[J]. J Neurosci, 1996, 16:4491-4500. DOI: 10.1523/JNEUROSCI.16-14-04491.1996
    [14]
    Rodrigue KM, Raz N. Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults[J]. J Neurosci, 2004, 24:956-963. DOI: 10.1523/JNEUROSCI.4166-03.2004
    • Related Articles

  • Related Articles

    [1]ZHANG Zhanjie, XIAO Yunqing, CHANG Qing, PAN Hui, ZHOU Jiong, GAO Jingsong, ZHANG Yu, MA Xiaojun. Strengthening the Maternal Health Management System to Safeguard Regional Maternal and Child Safety[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2025-0118
    [2]ZHENG Jiaojie, ZHANG Mingzi, SI Loubin, CHEN Jie, WANG Xiaojun, LONG Xiao, XIONG Wei. Journey and Significance of Quality Control in Medical Safety for China's Plastic Surgery and Aesthetic Medicine Professions[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(6): 1233-1237. DOI: 10.12290/xhyxzz.024-0487
    [3]ZHOU Jiong, WANG Shuchang, MA Xiaojun. Improving Medical Quality and Safety Through DRG Payment Model[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(5): 981-986. DOI: 10.12290/xhyxzz.2024-0479
    [4]ZHANG Yu, ZHAO Mengyun, PEI Lijian, GONG Yahong, RUAN Xia, ZHANG Yuguan, XIA Di, LU Zhilong, ZHANG Zhanjie, ZHOU Jiong, FU Chenwei, GAO Jinsong, HUANG Yuguang. Epidural Labor Analgesia: Comfort and Safety Run in Parallel, with Teaching and Quality Control Complementing Each Other[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 246-250. DOI: 10.12290/xhyxzz.2024-0026
    [5]ZHENG Jiaojie, ZHANG Mingzi, SI Loubin, CHEN Jie, WANG Xiaojun, LONG Xiao, XIONG Wei. The Journey and Significance of Quality Control in Medical Safety for China's Plastic Surgery and Aesthetic Medicine Professions[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2024-0487
    [6]WEI Mengchao, WANG Wenda, WANG Shijun, ZHANG Zhijun, WEN Jin. Preliminary Efficacy of Combined Laparoscopy and Cystoscopy in the Treatment of Bladder Diverticula[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 802-807. DOI: 10.12290/xhyxzz.2023-0044
    [7]HE Liyun, ZHANG Huabing, LI Yuxiu. Comprehensive Assessment and Rational Decision-making: Based on Recent FindingsAbout Safety of Glucagon-like Peptide-1 Receptor Agonists[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 948-952. DOI: 10.12290/xhyxzz.2022-0391
    [8]SUN Wenjuan, ZOU Yuzhen, ZHANG Fan, ZHANG Lu, ZHAO Lin, BAI Chunmei, ZHANG Feng, XU Yan, MAO Feng, LI Jing, GU Yu, FAN Xinrong, WANG Mengzhao, ZHOU Daobin, ZHANG Zhanjie, ZHAO Bin, DU Xiaoli, ZHANG Bo, SUN Xueqin, LONG Xiao, CHANG Qing, HU Bingshui, PAN Hui, WU Wenming. Design and Analysis of the Operation Effect of the Safety Management System for Antitumor Drugs[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 461-467. DOI: 10.12290/xhyxzz.2021-0704
    [9]De-qian MENG, Lu LI, Jin-jing LIU, Di WU, Nan JIANG, Yun-jiao YANG, Jia-xin ZHOU, Li WANG, Xiao-feng ZENG, Feng-chun ZHANG, Wen-jie ZHENG. Therapeutic Effect of Infliximab in the Treatment of Severe/Refractory Intestinal Behcet's Disease: A Single-center Retrospective Study[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(3): 237-242. DOI: 10.3969/j.issn.1674-9081.2019.03.009
    [10]Jing WEI, Li-li SHI, Jin-ya CAO. Systematic Assessment and Intervention of Mental Health Status Should Be Integrated into Patient Safety Management[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(3): 206-210. DOI: 10.3969/j.issn.1674-9081.2019.03.004

  • Cited by

    Periodical cited type(5)

    1. 苗丽晓，杨超，马建彩，张丽娜，李瑞雪，杨丽萍. 子痫前期并发幽门螺杆菌感染血清miR-31-5p、miR-4286表达及意义. 中华医院感染学杂志. 2024(13): 2032-2036 .
    2. 苏加碧，李姝静，谢飞，丁文. 幽门螺杆菌感染对妊娠期糖尿病患者血糖、血脂的影响. 中国现代药物应用. 2024(22): 67-69 .
    3. 于艳，白青山，才蔚涛. 子痫前期并发幽门螺旋杆菌感染患者血清miR-31-5p表达与不良妊娠结局的相关性研究. 现代检验医学杂志. 2022(01): 17-20+32 .
    4. 于艳，白青山，才蔚涛，高慧. 血清微小核糖核酸-4286与幽门螺旋杆菌感染的子痫前期患者妊娠结局的关系. 生物医学工程与临床. 2022(06): 755-760 .
    5. 范梦迪，李青菊，李俊，付威. 幽门螺旋杆菌感染对妊娠期糖尿病患者妊娠结局的影响. 实用医学杂志. 2021(04): 468-471 .

    Other cited types(3)

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (222) PDF downloads (4) Cited by(8)
    Related
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

      Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

      /

      DownLoad:  Full-Size Img  PowerPoint
      Return
      Return
      x Close Forever Close