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Volume 15 Issue 2
Mar.  2024
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CHEN Rong, WANG Xi, SONG An, WANG Jiajia, LI Wei, CHEN Shi, XING Xiaoping. Young Female, Fatigue, Hypokalemia, Hyperglycemia[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 456-461. DOI: 10.12290/xhyxzz.2023-0490
Citation: CHEN Rong, WANG Xi, SONG An, WANG Jiajia, LI Wei, CHEN Shi, XING Xiaoping. Young Female, Fatigue, Hypokalemia, Hyperglycemia[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 456-461. DOI: 10.12290/xhyxzz.2023-0490
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Young Female, Fatigue, Hypokalemia, Hyperglycemia

  • Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission of the People's Republic of China, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China

Funds: 

National High Level Hospital Clinical Research Funding 2022-PUMCH-A-015

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  • Corresponding author:

    XING Xiaoping, E-mail: xiaopingxing@126.com

  • Received Date: October 22, 2023
  • Accepted Date: November 19, 2023
  • Issue Publish Date: March 29, 2024
    Graphical Abstract
    • Abstract
  • We report a case of a young female patient with fatigue, hypokalemia, and hyperglycemia. She had past-history of diabetes mellitus, and was admitted to hospital with a history of fatigue and hypokalemia for 5 years. The patient's examination indicated hypokalemia, hypomagnesemia, metabolic alkalosis, hypocalciuria, and SLC12A3 gene pathogenic mutation. The diagnosis was Gitelman syndrome. Potassium and magnesium supplements were given to improve the patient's fatigue. Serum potassium and magnesium were normal. The blood glucose reached standard after treatment with oral hypoglycemic drugs. This article incorporates literature review to sort out the diagnosis and treatment of Gitelman syndrome, in order to provide feasible reference for clinicians.
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    • References (22)
  • [1]
    Gitelman综合征诊治专家共识协作组. Gitelman综合征诊治专家共识[J]. 中华内科杂志, 2017, 56(9): 712-716.

    Gitelman Syndrome Collaborative Study Group. Expert consensus for the diagnosis and treatment of patients with Gitelman syndrome[J]. Chin J Intern Med, 2017, 56(9): 712-716.
    [2]
    彭晓艳, 蒋兰萍, 袁涛, 等. 氯离子清除试验在Gitelman综合征鉴别诊断中的应用[J]. 中国医学科学院学报, 2016, 38(3): 275-282. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYKX201603006.htm

    Peng X Y, Jiang L P, Yuan T, et al. Value of chloride clearance test in differential diagnosis of Gitelman syndrome[J]. Acta Acad Med Sin, 2016, 38(3): 275-282. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYKX201603006.htm
    [3]
    Vargas-Poussou R, Dahan K, Kahila D, et al. Spectrum of mutations in Gitelman syndrome[J]. J Am Soc Nephrol, 2011, 22(4): 693-703. DOI: 10.1681/ASN.2010090907
    [4]
    中国研究型医院学会罕见病分会, 中国罕见病联盟, 北京罕见病诊疗与保障学会, 等. Gitelman综合征诊疗中国专家共识(2021版)[J]. 协和医学杂志, 2021, 12(6): 902-912. DOI: 10.12290/xhyxzz.2021-0555

    Rare Diseases Society of Chinese Research Hospital Association, National Rare Diseases Committee, Beijing Rare Disease Diagnosis, Treatment and Protection Society, et al. Expert consensus for the diagnosis and treatment of Gitelman syndrome in China (2021)[J]. Med J PUMCH, 2021, 12(6): 902-912. DOI: 10.12290/xhyxzz.2021-0555
    [5]
    Jeck N, Konrad M, Peters M, et al. Mutations in the chloride channel gene, CLCNKB, leading to a mixed Bartter-Gitelman phenotype[J]. Pediatr Res, 2000, 48(6): 754-758. DOI: 10.1203/00006450-200012000-00009
    [6]
    Kaito H, Nozu K, Fu X J, et al. Detection of a transcript abnormality in mRNA of the SLC12A3 gene extracted from urinary sediment cells of a patient with Gitelman's syndrome[J]. Pediatr Res, 2007, 61(4): 502-505. DOI: 10.1203/01.pdr.0000265051.26718.b5
    [7]
    Demoulin N, Aydin S, Cosyns J P, et al. Gitelman syndrome and glomerular proteinuria: a link between loss of sodium-chloride cotransporter and podocyte dysfunction?[J]. Nephrol Dial Transplant, 2014, 29(Suppl 4): iv117-iv120. DOI: 10.1093/ndt/gfu075
    [8]
    Zhong F, Ying H, Jia W, et al. Characteristics and follow-up of 13 pedigrees with Gitelman syndrome[J]. J Endocrinol Invest, 2019, 42(6): 653-665. DOI: 10.1007/s40618-018-0966-1
    [9]
    Tseng M H, Yang S S, Hsu Y J, et al. Genotype, phenotype, and follow-up in Taiwanese patients with salt-losing tubulopathy associated with SLC12A3 mutation[J]. J Clin Endocrinol Metab, 2012, 97(8): E1478-E1482. DOI: 10.1210/jc.2012-1707
    [10]
    Yuan T, Jiang L P, Chen C, et al. Glucose tolerance and insulin responsiveness in Gitelman syndrome patients[J]. Endocr Connect, 2017, 6(4): 243-252. DOI: 10.1530/EC-17-0014
    [11]
    Shafi T, Appel L J, Miller E R 3rd, et al. Changes in serum potassium mediate thiazide-induced diabetes[J]. Hypertension, 2008, 52(6): 1022-1029. DOI: 10.1161/HYPERTENSIONAHA.108.119438
    [12]
    Piuri G, Zocchi M, Della Porta M, et al. Magnesium in obesity, metabolic syndrome, and type 2 diabetes[J]. Nutrients, 2021, 13(2): 320. DOI: 10.3390/nu13020320
    [13]
    Kostov K. Effects of magnesium deficiency on mechanisms of insulin resistance in type 2 diabetes: focusing on the processes of insulin secretion and signaling[J]. Int J Mol Sci, 2019, 20(6): 1351. DOI: 10.3390/ijms20061351
    [14]
    Bothou C, Beuschlein F, Spyroglou A. Links between aldosterone excess and metabolic complications: a comprehen-sive review[J]. Diabetes Metab, 2020, 46(1): 1-7. DOI: 10.1016/j.diabet.2019.02.003
    [15]
    Liu Z Y, Wang S, Zhang R X, et al. A novel compound heterozygous variant of the SLC12A3 gene in Gitelman syndrome with diabetes and the choices of the appropriate hypoglycemic drugs: a case report[J]. BMC Med Genomics, 2021, 14(1): 198. DOI: 10.1186/s12920-021-01047-1
    [16]
    Cizmecioglu A. Metformin-and gliclazide-based diabetes treatment experience in a patient with Gitelman syndrome[J]. Acta Endocrinol (Buchar), 2022, 18(2): 241-243. DOI: 10.4183/aeb.2022.241
    [17]
    He G Y, Gang X K, Sun Z H, et al. Type 2 diabetes mellitus caused by Gitelman syndrome-related hypokalemia: a case report[J]. Medicine (Baltimore), 2020, 99(29): e21123. DOI: 10.1097/MD.0000000000021123
    [18]
    陈正, 吴娟, 邱瑜, 等. Gitelman综合征伴2型糖尿病一例报道[J]. 中国糖尿病杂志, 2022, 30(5): 370-374. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGTL202205009.htm

    Chen Z, Wu J, Qiu Y, et al. Gitelman syndrome with type 2 diabetes mellitus: a case report[J]. Chin J Diabet, 2022, 30(5): 370-374. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGTL202205009.htm
    [19]
    赵紫楠, 史琛, 胡欣, 等. 葡萄糖激酶激活剂多格列艾汀药学专家共识[J]. 中国医院药学杂志, 2024, 44(3): 245-250.

    Zhao Z N, Shi C, Hu X, et al. Expert consensus on the pharmacy of glucokinase agonist dorzagliatin[J]. Chin J Hosp Pharm, 2024, 44(3): 245-250.
    [20]
    Chow E, Wang K, Lim C K P, et al. Dorzagliatin, a dual-acting glucokinase activator, increases insulin secretion and glucose sensitivity in glucokinase maturity-onset diabetes of the young and recent-onset type 2 diabetes[J]. Diabetes, 2023, 72(2): 299-308. DOI: 10.2337/db22-0708
    [21]
    Zhu D L, Li X Y, Ma J H, et al. Dorzagliatin in drug-naïve patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial[J]. Nat Med, 2022, 28(5): 965-973. DOI: 10.1038/s41591-022-01802-6
    [22]
    Umpierrez G, Korytkowski M. Diabetic emergencies—ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemia[J]. Nat Rev Endocrinol, 2016, 12(4): 222-232. DOI: 10.1038/nrendo.2016.15
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