Research Progress on the Mechanism of Infection in Autoimmune Diseases

CHENG Linlin; LI Zhan; LI Yongzhe

doi:10.12290/xhyxzz.2023-0268

Volume 14 Issue 5

Sep. 2023

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CHENG Linlin, LI Zhan, LI Yongzhe. Research Progress on the Mechanism of Infection in Autoimmune Diseases[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 925-931. doi: 10.12290/xhyxzz.2023-0268

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CHENG Linlin, LI Zhan, LI Yongzhe. Research Progress on the Mechanism of Infection in Autoimmune Diseases[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 925-931. doi: 10.12290/xhyxzz.2023-0268

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Research Progress on the Mechanism of Infection in Autoimmune Diseases

doi: 10.12290/xhyxzz.2023-0268

CHENG Linlin^{1, 2},
LI Zhan^{1, 2},
LI Yongzhe^{1, 2
,
,}

1.
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
2.
State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

National Key Research and Development Program of China 2018YFE0207300

National High-level Hospital Clinical Research Funding 2022-PUMCH-B-124

Beijing Municipal Natural Science Foundation Project M23008

Beijing Municipal Natural Science Foundation Project 7234383

China Postdoctoral Science Foundation 2023T160060

More Information

Corresponding author: LI Yongzhe, E-mail: yongzhelipumch@126.com
Received Date: 2023-06-05
Accepted Date: 2023-07-17

Available Online: 2023-08-02

Publish Date: 2023-09-30

Abstract

Abstract

The pathogenesis of autoimmune diseases (AID) is a complex process. In recent years, an increasing number of evidence has shown that infection plays a key role in driving the occurrence and progression of AID, particularly in individuals with underlying genetic predisposition. This provides a new and broader perspective for clinical examination of the causes and potential mechanisms of AID. In this review, we aim to summarize the latest research progress on the relationship between pathogenic microorganisms and autoimmunity/AID, with the goal of exploring the etiology and pathogenesis of common AID from an etiological perspective. By integrating existing evidence, we hope to deepen the understanding of AID pathogenesis and provide valuable insights for disease prevention, clinical diagnosis and treatment.
- autoimmunity,
- pathogenesis,
- pathogenic microorganisms,
- molecular mimicry,
- SARS-CoV-2

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References(64)

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Research Progress on the Mechanism of Infection in Autoimmune Diseases

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