Research Progress on the Animal Models of Neuromyelitis Optica Spectrum Disorders-related Neuropathic Pain

SONG Shujia; PEI Lijian; XU Yan; ZHANG Xue; HUANG Yuguang

doi:10.12290/xhyxzz.2022-0647

Volume 14 Issue 3

May 2023

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Medical Journal of Peking Union Medical College Hospital > 2023 > 14(3): 598-602. > DOI: 10.12290/xhyxzz.2022-0647

SONG Shujia, PEI Lijian, XU Yan, ZHANG Xue, HUANG Yuguang. Research Progress on the Animal Models of Neuromyelitis Optica Spectrum Disorders-related Neuropathic Pain[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(3): 598-602. DOI: 10.12290/xhyxzz.2022-0647

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Research Progress on the Animal Models of Neuromyelitis Optica Spectrum Disorders-related Neuropathic Pain

1.
Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
2.
Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

National High Level Hospital Clinical Research Funding 2022-PUMCH-B-006

Fundamental Research Funds for the Central Universities 3332021015

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Corresponding author:
HUANG Yuguang, E-mail: garypumch@163.com
Received Date: November 13, 2022
Accepted Date: December 11, 2022
Available Online: January 29, 2023
Issue Publish Date: May 29, 2023

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Abstract

Abstract

Neuromyelitis optica spectrum disorders(NMOSD), an inflammatory demyelinating disease of central nervous system, is characterized by optic neuritis, longitudinally extensive transverse myelitis, and neuropathic pain. Given the lack of mature animal models, the mechanism of neuropathic pain in NMOSD is still unclear, although some studies have reported neuropathic pain in NMOSD models. It is therefore necessary to build a reliable and feasible animal model of NMOSD related neuropathic pain, in order to provide scientific support for the mechanism and the mining of therapeutic targets. This article reviews the research progress of the establishment of NMOSD-related neuropathic pain animal models and their applications, and provides a reference for the establishment of ideal NMOSD neuropathic pain animal models.
- neuromyelitis optica spectrum disorders,
- demyelinating disease,
- neuropathic pain,
- animal models

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