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Volume 14 Issue 2
Mar.  2023
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LIN Meijia, ZENG Yeting, WANG Xinrui, HUANG Xiongfei. Research Progress of Isocitrate Dehydrogenase Gene Mutation Therapy[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 346-352. DOI: 10.12290/xhyxzz.2022-0176
Citation: LIN Meijia, ZENG Yeting, WANG Xinrui, HUANG Xiongfei. Research Progress of Isocitrate Dehydrogenase Gene Mutation Therapy[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 346-352. DOI: 10.12290/xhyxzz.2022-0176
shu

Research Progress of Isocitrate Dehydrogenase Gene Mutation Therapy

  • 1.

    Department of Pathology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350004, China

  • 2.

    National Health Commission Key Laboratory of Nonhuman Primate Fertility Regulation Technology Evaluation (Fujian Maternity and Child Health Hospital), Fuzhou 350013, China

  • 3.

    Department of Pathology, The 900th Hospital of Joint Logistic Support Force, People's Liberation Army, Fuzhou 35001, China

  • 4.

    Medical Research Center, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China

  • 5.

    Key Laboratory of Gastrointestinal Malignancy of Ministry of Education, Fujian Medical University, Fuzhou 350108, China

Funds: 

Natural Science Foundation of Fujian Province 2022J01662

More Information
  • Corresponding author:

    HUANG Xiongfei, E-mail: 15705917895@163.com

  • Received Date: April 02, 2022
  • Accepted Date: September 06, 2022
  • Available Online: December 29, 2022
  • Issue Publish Date: March 29, 2023
    Graphical Abstract
    • Abstract
  • Isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, plays an important role in cellular energy metabolism. When the IDH gene is mutated, the enzyme activity is altered, resulting in an accumulation of a large amount of the tumor metabolite 2-hydroxyglutaric acid (2-HG), causing severe epigenetic deregulation and dysregulation of gene expression, and promoting tumorigenesis. Recent studies have shown that IDH1 and IDH2 mutations are closely related to the occurrence and development of a variety of tumors such as glioma, acute myeloid leukemia(AML) and intrahepatic cholangiocarcinoma(iCCA) as well as their clinical treatment. It is of great significance to use IDH gene mutations as molecular indicators for detecting glioma, AML and iCCA tumorigenesis, and developing targeted drugs. This review is focused on the mechanism of IDH mutation, the relationship between mutant IDH and the development of multiple tumors, and the progress of treatment of IDH mutation in basic research and drug clinical trials.
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    • References (52)
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