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Volume 13 Issue 3
May  2022
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LIU Hui, LAN Hui, ZHAO Siya, WANG Zijun, SHI Qianling, LIU Xiao, ZHOU Qi, WANG Jianjian, LYU Meng, LIU Yunlan, YANG Nan, XUN Yangqin, LI Qinyuan, PEI Hang, LIU Xingrong, CHEN Yaolong. Investigation and Evaluation of Chinese Clinical Practice Guidelines Published in Medical Journals in 2019:Research Gaps[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 498-505. DOI: 10.12290/xhyxzz.2022-0029
Citation: LIU Hui, LAN Hui, ZHAO Siya, WANG Zijun, SHI Qianling, LIU Xiao, ZHOU Qi, WANG Jianjian, LYU Meng, LIU Yunlan, YANG Nan, XUN Yangqin, LI Qinyuan, PEI Hang, LIU Xingrong, CHEN Yaolong. Investigation and Evaluation of Chinese Clinical Practice Guidelines Published in Medical Journals in 2019:Research Gaps[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 498-505. DOI: 10.12290/xhyxzz.2022-0029
shu

Investigation and Evaluation of Chinese Clinical Practice Guidelines Published in Medical Journals in 2019:Research Gaps

  • 1.

    School of Public Health, Lanzhou University, Lanzhou 730000, China

  • 2.

    Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China

  • 3.

    The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China

  • 4.

    Department of Respiratory, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China

  • 5.

    Institute of Health Data Science, Lanzhou University, Lanzhou 730000, China

  • 6.

    Research Unit of Evidence-based Evaluation and Guidelines, Chinese Academy of Medical Sciences, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China

  • 7.

    WHO Collaborating Center for Guideline Implementation and Knowledge Translation, Lanzhou 730000, China

  • 8.

    Lanzhou University, an Affiliate of the Cochrane China Network, Lanzhou 730000, China

  • 9.

    Lanzhou University GRADE Center, Lanzhou 730000, China

Funds: 

National Social Science Fund of China 19ZDA142

National Key Research and Development Program of China 2018YFC1705500

Fundamental Research Funds for the Central Universities lzujbky-2021-ey13

More Information
  • Corresponding author:

    LIU Xingrong, E-mail: liuxr@lzu.edu.cn

    CHEN Yaolong, E-mail: chevidence@lzu.edu.cn

  • Received Date: January 15, 2022
  • Accepted Date: February 28, 2022
  • Available Online: March 24, 2022
  • Issue Publish Date: May 29, 2022
    Graphical Abstract
    • Abstract
  •   Objective  To investigate the reporting of research gaps in Chinese clinical practice guidelines published in medical journals in 2019 and to make targeted suggestions for standardising and clearly reporting research gaps.
      Methods  We systematically reviewed Chinese clinical practice guidelines published in medical journals in 2019, extracted and analyzed information relevant to research gaps.
      Results  Of the 226 guidelines published in 2019, 27 guidelines (11.9%) reported a total of 78 research gaps, and the median number of reports was 2(range: 1 to 10). Of these guidelines, 11 guidelines presented research gaps in separate sections such as "problems to be solved" "priority suggestions for future research "or" suggestions for future research ", while 16 guidelines integrated research gaps into other sections, such as" summary" "discussion" or "epilogue". In terms of content, the main focuses are on efficacy (15.4%, 12/78), safety (12.8%, 10/78), new methods/solutions/technologies/products (10.3%, 8/78) and biomarkers (9.0%, 7/78). In terms of clarity, only 45 research gaps (57.7%, 45/78) were deconstructed to include 2 or more of these elements according to the PICO (P, population; I, intervention; C, comparison; O, outcomes) principles.
      Conclusions  The reporting rate and the clarity of research gaps in the 2019 Chinese guidelines need to be improved, and the location of research gaps is not fixed. It is recommended that guideline developers independently report on research gaps in the guideline and aim to make it standard, comprehensive and clear, so as to provide direction for future researches.
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    • References (33)
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