Volume 13 Issue 4
Jul.  2022
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ZHAO Huijia, WU Dong, WU Wenming. Research Advances of Hyperlipidemic Pancreatitis[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(4): 637-643. doi: 10.12290/xhyxzz.2021-0760
Citation: ZHAO Huijia, WU Dong, WU Wenming. Research Advances of Hyperlipidemic Pancreatitis[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(4): 637-643. doi: 10.12290/xhyxzz.2021-0760

Research Advances of Hyperlipidemic Pancreatitis

doi: 10.12290/xhyxzz.2021-0760
Funds:

National Key Research and Development Program of China 2019YFC1315901

Natural Science Foundation of Beijing Z190022

More Information
  • Corresponding author: WU Wenming, E-mail: wuwm@pumch.cn
  • Received Date: 2021-11-29
  • Accepted Date: 2022-01-18
  • Available Online: 2022-03-05
  • Publish Date: 2022-07-30
  • Hyperlipidemic pancreatitis (HLP) is one of the most important causes of acute pancreatitis. The pathogenesis is associated with the accumulation of free fatty acids which can activate the inflammatory response. Compared with other causes, HLP is more likely to have the clinical features characterized by more severe symptoms, more complications, and higher likelihood of persistent organ failure. The HLP patients always need lipid lowering therapy such as apheresis or insulin therapy to reduce serum triglyceride rapidly. Assessment of the presence of hyperlipidemia in patients of acute pancreatitis and prompt management are crucial for the prognosis and the prevention of recurrence. This article reviews the etiology, pathogenesis, clinical features, and treatment of hypertriglyceridemia-induced acute pancreatitis.
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  • [1] Zhu Y, Pan X, Zeng H, et al. A Study on the Etiology, Severity, and Mortality of 3260 Patients With Acute Pancreatitis According to the Revised Atlanta Classification in Jiangxi, China Over an 8-Year Period[J]. Pancreas, 2017, 46: 504-509. doi:  10.1097/MPA.0000000000000776
    [2] Li X, Ke L, Dong J, et al. Significantly different clinical features between hypertriglyceridemia and biliary acute pancreatitis: a retrospective study of 730 patients from a tertiary center[J]. BMC Gastroenterol, 2018, 18: 89. doi:  10.1186/s12876-018-0821-z
    [3] Eckel RH, Cornier MA. Update on the NCEP ATP-Ⅲ emerging cardiometabolic risk factors[J]. BMC Med, 2014, 12: 115. doi:  10.1186/1741-7015-12-115
    [4] Zheng CB, Zheng ZH, Zheng YP. Therapeutic plasma exchange for hyperlipidemic pancreatitis: Current evidence and unmet needs[J]. World J Clin Cases, 2021, 9: 5794-5803. doi:  10.12998/wjcc.v9.i21.5794
    [5] Jin M, Bai X, Chen X, et al. A 16-year trend of etiology in acute pancreatitis: The increasing proportion of hypertriglyceridemia-associated acute pancreatitis and its adverse effect on prognosis[J]. J Clin Lipidol, 2019, 13: 947-953. e1. doi:  10.1016/j.jacl.2019.09.005
    [6] Nawaz H, Koutroumpakis E, Easler J, et al. Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis[J]. Am J Gastroenterol, 2015, 110: 1497-1503. doi:  10.1038/ajg.2015.261
    [7] Jo SI, Chang JH, Kim TH, et al. Subsets associated with developing acute pancreatitis in patients with severe hypertriglyceridemia and the severity of pancreatitis[J]. Pancreatology, 2019, 19: 795-800. doi:  10.1016/j.pan.2019.08.002
    [8] Li Q, Hou C, Peng Y, et al. Diabetes and Younger Age Are Vital and Independent Risk Factors for Acute Pancreatitis in Patients with Severe Hypertriglyceridemia[J]. Biomed Res Int, 2019, 2019: 2620750.
    [9] Fredrickson DS. An international classification of hyperlipidemias and hyperlipoproteinemias[J]. Ann Intern Med, 1971, 75: 471-472. doi:  10.7326/0003-4819-75-3-471
    [10] Wang L, Xu T, Wang R, et al. Hypertriglyceridemia Acute Pancreatitis: Animal Experiment Research[J]. Dig Dis Sci, 2022, 67: 761-772. doi:  10.1007/s10620-021-06928-0
    [11] Paquette M, Hegele RA, Paré G, et al. A novel mutation in GPIHBP1 causes familial chylomicronemia syndrome[J]. J Clin Lipidol, 2018, 12: 506-510. doi:  10.1016/j.jacl.2018.01.011
    [12] Hernandez P, Passi N, Modarressi T, et al. Clinical Management of Hypertriglyceridemia in the Prevention of Cardiovascular Disease and Pancreatitis[J]. Curr Atheroscler Rep, 2021, 23: 72. doi:  10.1007/s11883-021-00962-z
    [13] Sun X, Zhou X, Dong B, et al. Generation of a gene-corrected isogenic iPSC line (AHQUi001-A-1) from a patient with familial hypertriglyceridemia (FHTG) carrying a hetero-zygous p. C310R (c. 928 T > C) mutation in LPL gene using CRISPR/Cas9[J]. Stem Cell Res, 2021, 52: 102230. doi:  10.1016/j.scr.2021.102230
    [14] Simha V. Management of hypertriglyceridemia[J]. BMJ, 2020, 371: m3109. doi:  10.1007/978-1-59745-533-6_10
    [15] Yuan G, Al-Shali KZ, Hegele RA. Hypertriglyceridemia: its etiology, effects and treatment[J]. CMAJ, 2007, 176: 1113-1120. doi:  10.1503/cmaj.060963
    [16] Eichenbaum-Voline S, Olivier M, Jones EL, et al. Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia[J]. Arterioscler Thromb Vasc Biol, 2004, 24: 167-174. doi:  10.1161/01.ATV.0000099881.83261.D4
    [17] Chang YT, Chang MC, Su TC, et al. Association of cystic fibrosis transmembrane conductance regulator (CFTR) mutation/variant/haplotype and tumor necrosis factor (TNF) promoter polymorphism in hyperlipidemic pancreatitis[J]. Clin Chem, 2008, 54: 131-138. doi:  10.1373/clinchem.2007.093492
    [18] Ivanova R, Puerta S, Garrido A, et al. Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis[J]. Hepatobiliary Pancreat Dis Int, 2012, 11: 96-101. doi:  10.1016/S1499-3872(11)60131-8
    [19] Cruciat G, Nemeti G, Goidescu I, et al. Hypertriglyceride-mia triggered acute pancreatitis in pregnancy-diagnostic approach, management and follow-up care[J]. Lipids Health Dis, 2020, 19: 2. doi:  10.1186/s12944-019-1180-7
    [20] Yang AL, McNabb-Baltar J. Hypertriglyceridemia and acute pancreatitis[J]. Pancreatology, 2020, 20: 795-800. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1399846
    [21] Valdivielso P, Ramírez-Bueno A, Ewald N. Current knowledge of hypertriglyceridemic pancreatitis[J]. Eur J Intern Med, 2014, 25: 689-694. doi:  10.1016/j.ejim.2014.08.008
    [22] Hu X, Gong L, Zhou R, et al. Variations in Gut Microbiome are Associated with Prognosis of Hypertriglyceridemia-Associated Acute Pancreatitis[J]. Biomolecules, 2021, 11: 695. doi:  10.3390/biom11050695
    [23] Le Chatelier E, Nielsen T, Qin J, et al. Richness of human gut microbiome correlates with metabolic markers[J]. Nature, 2013, 500: 541-546. https://www.nature.com/articles/nature12506
    [24] 中华医学会外科学分会胰腺外科学组. 中国急性胰腺炎诊治指南(2021)[J]. 中华外科杂志, 2021, 59: 578-587. doi:  10.3760/cma.j.cn112139-20210416-00172

    Chinese Pancreatic Surgery Association, Chinese Society of Surgery, Chinese Medical Association. Guidelines for diagnosis and treatment of acute pancreatitis in China (2021)[J]. Zhonghua Waike Zazhi, 2021, 59: 578-587. doi:  10.3760/cma.j.cn112139-20210416-00172
    [25] Carr RA, Rejowski BJ, Cote GA, et al. Systematic review of hypertriglyceridemia-induced acute pancreatitis: A more virulent etiology?[J]. Pancreatology, 2016, 16: 469-476. doi:  10.1016/j.pan.2016.02.011
    [26] Wang Q, Wang G, Qiu Z, et al. Elevated Serum Triglycerides in the Prognostic Assessment of Acute Pancreatitis: A Systematic Review and Meta-Analysis of Observational Studies[J]. J Clin Gastroenterol, 2017, 51: 586-593. doi:  10.1097/MCG.0000000000000846
    [27] 何文华, 祝荫, 朱勇, 等. 高甘油三酯血症与其他病因所致急性胰腺炎的病情严重程度及预后比较[J]. 中华医学杂志, 2016, 96: 2569-2572. doi:  10.3760/cma.j.issn.0376-2491.2016.32.011

    He WH, Zhu Y, Zhu Y, et al. Comparison of severity and clinical outcomes between hypertriglyceridemic pancreatitis and acute pancreatitis due to other causes[J]. Zhonghua Yixue Zazhi, 2016, 96: 2569-2572. doi:  10.3760/cma.j.issn.0376-2491.2016.32.011
    [28] Pascual I, Sanahuja A, García N, et al. Association of elevated serum triglyceride levels with a more severe course of acute pancreatitis: Cohort analysis of 1457 patients[J]. Pancreatology, 2019, 19: 623-629. doi:  10.1016/j.pan.2019.06.006
    [29] Anderson F, Thomson SR, Clarke DL, et al. Dyslipidaemic pancreatitis clinical assessment and analysis of disease severity and outcomes[J]. Pancreatology, 2009, 9: 252-257. doi:  10.1159/000212091
    [30] Zhang R, Deng L, Jin T, et al. Hypertriglyceridaemia-associated acute pancreatitis: diagnosis and impact on severity[J]. HPB (Oxford), 2019, 21: 1240-1249. doi:  10.1016/j.hpb.2019.01.015
    [31] Zafrir B, Saliba W, Jubran A, et al. Severe Hypertriglyceridemia-Related Pancreatitis: Characteristics and Predictors of Recurrence[J]. Pancreas, 2019, 48: 182-186. doi:  10.1097/MPA.0000000000001235
    [32] Wu BU, Batech M, Dong EY, et al. Influence of Ambulatory Triglyceride Levels on Risk of Recurrence in Patients with Hypertriglyceridemic Pancreatitis[J]. Dig Dis Sci, 2019, 64: 890-897. doi:  10.1007/s10620-018-5226-x
    [33] Vipperla K, Somerville C, Furlan A, et al. Clinical Profile and Natural Course in a Large Cohort of Patients With Hypertriglyceridemia and Pancreatitis[J]. J Clin Gastroenterol, 2017, 51: 77-85.
    [34] 高甘油三酯血症性急性胰腺炎诊治急诊共识专家组. 高甘油三酯血症性急性胰腺炎诊治急诊专家共识[J]. 中华急诊医学杂志, 2021, 30: 937-947. doi:  10.3760/cma.j.issn.1671-0282.2021.08.005
    [35] Garg R, Rustagi T. Management of Hypertriglyceridemia Induced Acute Pancreatitis[J]. Biomed Res Int, 2018, 2018: 4721357. https://www.hindawi.com/journals/bmri/2018/4721357/
    [36] Chen JH, Yeh JH, Lai HW, et al. Therapeutic plasma exchange in patients with hyperlipidemic pancreatitis[J]. World J Gastroenterol, 2004, 10: 2272-2274. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724982/
    [37] Gubensek J, Buturovic-Ponikvar J, Romozi K, et al. Factors affecting outcome in acute hypertriglyceridemic pancreatitis treated with plasma exchange: an observational cohort study[J]. PLoS One, 2014, 9: e102748. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105439/
    [38] Berberich AJ, Ziada A, Zou GY, et al. Conservative management in hypertriglyceridemia-associated pancreatitis[J]. J Intern Med, 2019, 286: 644-650. https://www.hindawi.com/journals/bmri/2018/4721357/
    [39] Coskun A, Erkan N, Yakan S, et al. Treatment of hypertriglyceridemia-induced acute pancreatitis with insulin[J]. Prz Gastroenterol, 2015, 10: 18-22. https://www.termedia.pl/Treatment-of-hypertriglyceridemia-induced-acute-pancreatitis-with-insulin,41,23551,0,1.html
    [40] Li J, Chen TR, Gong HL, et al. Intensive insulin therapy in severe acute pancreatitis: a meta-analysis and systematic review[J]. West Indian Med J, 2012, 61: 574-579.
    [41] Jin M, Peng JM, Zhu HD, et al. Continuous intravenous infusion of insulin and heparin vs plasma exchange in hypertriglyceridemia-induced acute pancreatitis[J]. J Dig Dis, 2018, 19: 766-772. https://www.ncbi.nlm.nih.gov/pubmed/4211890
    [42] He WH, Yu M, Zhu Y, et al. Emergent Triglyceride-lowering Therapy With Early High-volume Hemofiltration Against Low-Molecular-Weight Heparin Combined With Insulin in Hypertriglyceridemic Pancreatitis: A Prospective Randomized Controlled Trial[J]. J Clin Gastroenterol, 2016, 50: 772-778.
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