Expression of H3K27me3 in Tibetan Patients with Gastric Cancer and Its Significance

LUO Hanhuan; SHI Jie; BIANBA Zhaxi; YANG Xu; NIMA Zhuoma; WANG Qian; LI Mei; WANG Han; LIAO Ruiqian; CIREN Quzhen

doi:10.12290/xhyxzz.2021-0727

Volume 13 Issue 6

Nov. 2022

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Medical Journal of Peking Union Medical College Hospital > 2022 > 13(6): 1088-1093. > DOI: 10.12290/xhyxzz.2021-0727

LUO Hanhuan, SHI Jie, BIANBA Zhaxi, YANG Xu, NIMA Zhuoma, WANG Qian, LI Mei, WANG Han, LIAO Ruiqian, CIREN Quzhen. Expression of H3K27me3 in Tibetan Patients with Gastric Cancer and Its Significance[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 1088-1093. DOI: 10.12290/xhyxzz.2021-0727

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Expression of H3K27me3 in Tibetan Patients with Gastric Cancer and Its Significance

1.
Department of Pathology, Tibet Autonomous Region People's Hospital, Lhasa 850000, China
2.
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
3.
Department of General Surgery, Tibet Autonomous Region People's Hospital, Lhasa 850000, China
4.
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

Tibet Natural Science Funding Committee Grant XZ2017ZR-ZY33

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Corresponding author:
SHI Jie, E-mail: shijie@pumch.cn
Received Date: November 01, 2021
Accepted Date: December 12, 2021
Issue Publish Date: November 29, 2022

Graphical Abstract

Abstract

Abstract

Objective To investigate the expression and its significance of H3K27me3 in Tibetan patients with gastric cancer.
Methods Clinical and pathological data were retrospectively collected from Tibetan patients with gastric cancer in the Tibet Autonomous Region People's Hospital from August 2019 to August 2021 and Tibetan non-gastric cancer patients during the same period. The expression of H3K27me3 in gastric cancer tissues, corresponding adjacent normal gastric mucosa and normal gastric mucosa of Tibetan patients with non-gastric cancer tissues was detected by immunohistochemical method, and the differences of H3K27me3 expression between gastric cancer patients with different clinical and pathological characteristics was compared.
Results A total of 54 Tibetan gastric cancer patients and 55 Tibetan non-gastric cancer patients who met the inclusion and exclusion criteria were enrolled. H3K27me3 was localized in the nucleus, and the nucleus showed brownish-yellow granular staining when positively expressed. The high expression rate of H3K27me3 in gastric cancer tissues was significantly higher than that in adjacent normal gastric mucosa tissue[64.8%(35/54) vs. 29.6%(16/54), P < 0.001]and normal gastric mucosal tissue of Tibetan patients with non-gastric cancer[64.8%(35/54) vs. 34.5%(19/55), P=0.002], and the high expression rate of H3K27me3 in the adjacent normal gastric mucosa tissue was not significantly different from that in normal gastric mucosal tissue of Tibetan patients with non-gastric cancer(P=0.683). H3K27me3 expression in gastric cancer tissues was not related to gender, age, degree of differentiation, depth of invasion, maximum tumor size, Lauren's classification, lymph node metastasis, vascular and nerve invasion and TNM stage.
Conclusions H3K27me3 is highly expressed in gastric cancer tissues of Tibetan people in Tibet. There is no significant difference in H3K27me3 positive expression cells in adjacent tissues and normal gastric mucosa. The significance of H3K27me3 in Tibetan patients with gastric cancer is uncertain and requires further investigations.
- Tibet autonomous region,
- Tibetan,
- gastric cancer,
- H3K27me3,
- pathological features

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Expression of H3K27me3 in Tibetan Patients with Gastric Cancer and Its Significance