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Volume 13 Issue 4
Jul.  2022
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2022  >  13(4): 644-651
WANG Xixi, WAN Xinhua. Clinical Diagnosis and Treatment of Tardive Dyskinesia[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(4): 644-651. doi: 10.12290/xhyxzz.2021-0717
Citation: WANG Xixi, WAN Xinhua. Clinical Diagnosis and Treatment of Tardive Dyskinesia[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(4): 644-651. doi: 10.12290/xhyxzz.2021-0717
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Clinical Diagnosis and Treatment of Tardive Dyskinesia

doi: 10.12290/xhyxzz.2021-0717

  • Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

National Natural Science Foundation of China 81971074

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  • Corresponding author: WAN Xinhua, E-mail: wxhpumch@163.com
  • Received Date: 2021-10-29
  • Accepted Date: 2021-11-22
    • Available Online: 2022-01-30
  • Publish Date: 2022-07-30
    Abstract
  • Tardive dyskinesia(TD) is a kind of disabling movement disorder characterized by involuntary movements of the face, neck, extremities or trunk that results from long-term use of dopamine receptor blocking agents.The most common reason is the use of antipsychotic drug(APD). Identified risk factors include the type, dose, as well as the duration of APD. Age, sex, genetics also play a role. CYP2D6, DRD2, DRD3, HTR2A, HTR2C, VMAT2, MnSOD, HSPG2 gene may be involved. The pathogenesis is not clear. Three hypotheses are proposed: dopamine receptor super-sensitivity, oxidative stress and maladaptive synaptic plasticity. TD is quite hard to cure, prevention is of vital importance. This article reviews the clinical diagnosis and treatment of TD, so as to further deepen medical staff's understanding of TD.
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