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Volume 13 Issue 3
May  2022
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2022  >  13(3): 480-486
SU Pengfei, YU Jianchun. Progress in the Research on the Role of Tumor-associated Macrophages in Drug-resistance and Treatment of Tumors[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 480-486. doi: 10.12290/xhyxzz.2021-0605
Citation: SU Pengfei, YU Jianchun. Progress in the Research on the Role of Tumor-associated Macrophages in Drug-resistance and Treatment of Tumors[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 480-486. doi: 10.12290/xhyxzz.2021-0605
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Progress in the Research on the Role of Tumor-associated Macrophages in Drug-resistance and Treatment of Tumors

doi: 10.12290/xhyxzz.2021-0605

  • Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

Beijing Municipal Commission of Science and Technology Foundation D171100006517002

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  • Corresponding author: YU Jianchun, E-mail: yu-jch@163.com
  • Received Date: 2021-08-20
  • Accepted Date: 2021-10-12
    • Available Online: 2022-04-12
  • Publish Date: 2022-05-30
    Abstract
  • The development of drug-resistance is the interactional result between tumor cells and tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are the main immune cells in TME, and act as the bridge between the inflammatory microenviroment and malignant phenotype of tumor cells. They are closely related to drug-resistance and tumor progression, and the infiltration of M2 macrophages indicates a poor clinical outcome. This paper reviews the progress in research of the role of TAMs in drug-resistance and treatment of tumors, providing references for decreasing drug-resistance and increasing the curative effects.
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