ZHANG Liqin, ZHAO Yang, TIAN Xu, GAO Zhiqiang, FENG Guodong. Analysis of the Effect of Facial Nerve Processing in the Surgery of Paraganglioma of the Lateral Skull Base Area[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(6): 946-951. DOI: 10.12290/xhyxzz.2021-0576
Citation: ZHANG Liqin, ZHAO Yang, TIAN Xu, GAO Zhiqiang, FENG Guodong. Analysis of the Effect of Facial Nerve Processing in the Surgery of Paraganglioma of the Lateral Skull Base Area[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(6): 946-951. DOI: 10.12290/xhyxzz.2021-0576

Analysis of the Effect of Facial Nerve Processing in the Surgery of Paraganglioma of the Lateral Skull Base Area

Funds: 

National Natural Science Foundation of China 81870735

National Multidisciplinary Cooperative Diagnosis and Treatment Capacity Building Project for Major Diseases 

Beijing Science and Technology Program-Research and Development of Pharmaceutical Innovation Varieties and Industrial Support Platform Capacity-building Projects Z191100007619040

More Information
  • Corresponding author:

    FENG Guodong  Tel: 86-10-69156301, E-mail: fengguodong2013@163.com

  • Received Date: August 04, 2021
  • Accepted Date: October 18, 2021
  • Issue Publish Date: November 29, 2021
  •   Objective  To summarize the key points of the operation related to the facial nerve function after surgery of paraganglioma involving the jugular foramen in the lateral skull base.
      Methods  We retrospectively analyzed the clinical data of patients with lateral skull base paraganglioma involving jugular foramen that were diagnosed and treated in Peking Union Medical College Hospital from August 2015 to January 2021. According to the relationship between the tumor and the facial nerve, the facial nerve was treated in different ways during the operation. The postoperative facial nerve function of patients with different treatments is summarized.
      Results  A total of 30 patients with lateral skull base paraganglioma in the jugular foramen area were included. The Fisch classification of these patients was as followed: C1(n=3), C2(n=6), C2De1(n=2), C2Di1(n=2), C3De1(n=7), C3Di1(n=5), C3Di2(n=3), C4De1(n=1), C4Di1(n=1). Preoperative facial nerve function assessed by House-Brackmann (HB) grade: grade Ⅰ-Ⅱ (n=22), grade Ⅲ (n=2), grade Ⅳ (n=3), grade Ⅴ(n=2), grade Ⅵ(n=1). All tumors were completely resected, which was verified by post-operational MRI. No recurrence was observed during the medium follow-up of 886 days. All of the postoperative nerve function refers to the results of the last follow-up. Anterior facial nerve rerouting was performed in 15 cases whose tumor did not invade the facial nerve. The postoperative facial nerve function was HB grade Ⅰ-Ⅱ in 13 cases and HB grade Ⅲ in 2 cases. The tumors were adhesive to the facial nerve in 2 cases. The tumors and the facial nerve were successfully separated in both cases; one achieved HB grade Ⅰ-Ⅱ, while the other was HB grade Ⅰ-Ⅱ postoperatively. In 13 cases, the tumor wrapped the facial nerve. Among those patients, the tumor was separated from the facial nerve in 1 case, with the postoperative facial nerve function of HB grade Ⅲ. In the remaining 12 cases, the facial nerve was resected together with the tumor. Facial nerve reconstruction was performed in 3 cases in the same or the second surgery. The postoperative facial nerve function was HB gradeⅠ-Ⅱ in 1 case and HB grade Ⅲ in the other 2 cases. The postoperative facial nerve function in the remaining 9 cases that did not receive facial nerve reconstruction was HB grade Ⅵ.
      Conclusions  In patients with lateral skull base paraganglioma, anterior facial nerve rerouting has a slight effect on the function of facial nerve, if the tumor does not invade the facial nerve. It is difficult to separate the tumor and the facial nerve, if the facial nerve is wrapped by the tumor, and the rate of postoperative facial nerve paralysis is higher in these cases.
  • [1]
    Berends A, Buitenwerf E, Krijger RD, et al. Incidence of pheochromocytoma and sympathetic paraganglioma in the Netherlands: A nationwide study and systematic review[J]. Eur J Intern Med, 2018, 51: 68-73. DOI: 10.1016/j.ejim.2018.01.015
    [2]
    Corssmit E, Snel M, Kapiteijn E. Malignant pheochromocytoma and paraganglioma: management options[J]. Curr OpinOncol, 2019, 32: 20-26. http://journals.lww.com/co-oncology/Fulltext/2020/01000/Malignant_pheochromocytoma_and_paraganglioma_.5.aspx
    [3]
    Fisch U. The infratemporal fossa approach to tumors of the temporal bone and the base of the skull[J]. J Laryngol Otol, 1978, 92: 949-967. DOI: 10.1017/S0022215100086382
    [4]
    House JW, Brackmann DE. Facial nerve grading system[J]. Otolaryngol Head Neck Surg, 1985, 93: 146-147. DOI: 10.1177/019459988509300202
    [5]
    Carlson ML, Sweeney AD, Wanna GB, et al. Natural history of glomus jugulare: a review of 16 tumors managed with primary observation[J]. Otolaryngol Head Neck Surg, 2015, 152: 98-105. DOI: 10.1177/0194599814555839
    [6]
    Jansen JC, van den Berg R, Kuiper A, et al. Estimation of growth rate in patients with head and neck paragangliomas influences the treatment proposal[J]. Cancer, 2015, 88: 2811-2816.
    [7]
    Megerian CA, Mckenna MJ, Ojemann RG. Delayed facial paralysis after acoustic neuroma surgery: factors influencing recovery[J]. Am J Otol, 1996, 17: 630-633. http://www.europepmc.org/abstract/MED/8841712
    [8]
    Ahn J, Ryu NG, Lim J, et al. Prognostic factors of facial nerve function after vestibular schwannoma removal via translabyrinthine approach[J]. Acta Otolaryngol, 2019, 139: 541-546. DOI: 10.1080/00016489.2019.1592223
    [9]
    顾晓明, 雷德林, 周树夏, 等. 面部运动神经损伤后的手术治疗时机与疗效分析[J]. 中华口腔医学杂志, 2001, 36: 96-98. DOI: 10.3760/j.issn:1002-0098.2001.02.005

    Gu XM, Lei DL, Zhou SX, et al. Analysis of the relation between the operation time and functional recovery for the injured facial motor nerve[J]. Zhonghua Kouqiang Yixue Zazhi, 2001, 36: 96-98. DOI: 10.3760/j.issn:1002-0098.2001.02.005
    [10]
    Liu H, Wen W, Huang H, et al. Recurrent Pleomorphic Adenoma of the Parotid Gland: Intraoperative Facial Nerve Monitoring during Parotidectomy[J]. Otolaryngol Head Neck Surg, 2014, 151: 87-91. DOI: 10.1177/0194599814528098
    [11]
    Makeieff M, Venail F, Cartier C, et al. Continuous facial nerve monitoring during pleomorphic adenoma recurrence surgery[J]. Laryngoscope, 2005, 115: 1310-1314. DOI: 10.1097/01.MLG.0000166697.48868.8C
  • Related Articles

    [1]ZHANG Ning, YANG Chenhao, ZHOU Liangrui, SUN Xiaohong, LIU Xiaohong, KANG Lin, LI Ji, LI Hailong. Cronkhite-Canada Syndrome Combined with Asymptomatic Novel Coronavirus Infection: A Case Report[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 406-412. DOI: 10.12290/xhyxzz.2023-0476
    [2]ZHANG Lu, LI Jian. Castleman Disease in China: State-of-the-art Technology Before the Era of IL-6 Targeted Therapy[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 911-914. DOI: 10.12290/xhyxzz.2023-0227
    [3]LUO Jichang, WANG Tao, JIAO Liqun. Treatment of Intracranial Atherosclerotic Stenosis: Current Debates and Future Directions[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 907-914. DOI: 10.12290/xhyxzz.2022-0592
    [4]Rare Diseases Society of Chinese Research Hospital Association, National Rare Diseases Committee, Beijing Rare Disease Diagnosis, Treatment and Protection Society, Gitelman Syndrome Consensus Working Group. Expert Consensus for the Diagnosis and Treatment of Gitelman Syndrome in China (2021)[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(6): 902-912. DOI: 10.12290/xhyxzz.2021-0555
    [5]Xiao-bo ZHANG, Zheng-yu JIN. Does Acute Cerebral Venous Sinus Thrombosis Require Endovascular Treatment?[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(2): 140-143. DOI: 10.3969/j.issn.1674-9081.20190271
    [6]Ming-sheng MA, Xü-de ZHANG, Min WEI, Shi-min ZHAO, Zheng-qing QIU. Efficacy of Low Dose Corticosteroid Therapy in Duchenne Muscular Dystrophy[J]. Medical Journal of Peking Union Medical College Hospital, 2014, 5(4): 384-388. DOI: 10.3969/j.issn.1674-9081.2014.04.006
    [7]Ying ZHANG, Jin-song GAO, Jun-tao LIU, Hai-yuan LIU, Ying-na SONG, Xiao-ming GONG, Zhi-jing SUN. Effectiveness of B-lynch Suture in Treatment and Prevention of Postpartum Hemorrhage[J]. Medical Journal of Peking Union Medical College Hospital, 2013, 4(2): 174-177. DOI: 10.3969/j.issn.1674-9081.2013.02.019
    [8]Jie LIU, Yue-ping ZENG, Chun-xia HE, Qin LONG, Hong-zhong JIN, Qiu-ning SUN. Corticosteroids plus Intravenous Immunoglobulin in the Treatment of 7 Cases with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(4): 381-385. DOI: 10.3969/j.issn.1674-9081.2012.04.004
    [9]Shuai TANG, Jie YI, Yu-guang HUANG. Cardiovascular Responses of Intubation with Shikani Seeing Optical Stylet and Macintosh Laryngoscope[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(3): 314-317. DOI: 10.3969/j.issn.1674-9081.2012.03.015
    [10]Xiao-hua SHI, Zhi-yong LIANG, Huan-wen WU, Xin-yu REN, Tong-hua LIU. Effect of RNA Interference Plasmid on the Expression of Oncogene AKT2 in Pancreatic Cancer Cell Line Panc-1[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(1): 102-108. DOI: 10.3969/j.issn.1674-9081.2012.01.021
  • Cited by

    Periodical cited type(3)

    1. 仇芳娟,郭小靖,彭会琴. 大颗粒绷带包扎联合瑜伽操方案在乳腺癌术后患者中的应用. 当代护士(中旬刊). 2025(01): 88-91 .
    2. 李叶玭,董菲妮,洪志鹏. 改良绷带加压包扎法结合针对性护理对乳腺癌术后上肢淋巴水肿的影响. 中国卫生标准管理. 2024(15): 170-174 .
    3. 吕子岩,蓝敏. 乳腺癌相关淋巴水肿的康复治疗. 加速康复外科杂志. 2024(02): 86-90 .

    Other cited types(0)

Catalog

    Article Metrics

    Article views (564) PDF downloads (23) Cited by(3)
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return
    x Close Forever Close