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Volume 13 Issue 3
May  2022
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2022  >  13(3): 493-497
WANG Chenyu, LONG Xiao, ZENG Ang, HUANG Jiuzuo, WANG Xiaojun. The Plastic Surgery for Localized Scleroderma: Progress in Diagnosis and Treatment and Opinions from Peking Union Medical College Hospital[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 493-497. doi: 10.12290/xhyxzz.2021-0394
Citation: WANG Chenyu, LONG Xiao, ZENG Ang, HUANG Jiuzuo, WANG Xiaojun. The Plastic Surgery for Localized Scleroderma: Progress in Diagnosis and Treatment and Opinions from Peking Union Medical College Hospital[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 493-497. doi: 10.12290/xhyxzz.2021-0394
shu

The Plastic Surgery for Localized Scleroderma: Progress in Diagnosis and Treatment and Opinions from Peking Union Medical College Hospital

doi: 10.12290/xhyxzz.2021-0394
  • 1.

    Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

  • 2.

    Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

National Key Research and Development Program of China 2016YFA0101003

National Key Research and Development Program of China 2020YFE0201600

Medical Science and Health Technology Innovation Project 2021-I2M-1-003

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  • Corresponding author: LONG Xiao, E-mail: pumclongxiao@126.com
  • Received Date: 2021-05-17
  • Accepted Date: 2021-08-20
    • Available Online: 2022-01-06
  • Publish Date: 2022-05-30
    Abstract
  • Localized scleroderma is a rare auto-immune disorder characterized by inflammation and fibrosis of the skin and subcutaneous fat in the affected area, leaving aesthetic impairment to the patients.Such patients often seek plastic surgery for the treatment. This article summarizes the pathophysiology and preoperative evaluation of localized scleroderma, discusses the progress and clinical dilemma of its surgical treatment, and shares the opinions on the diagnosis and treatment of a single center in Peking Union Medical College Hospital.
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  • [1] Toki S, Motegi S, Yamada K, et al. Clinical and laboratory features of systemic sclerosis complicated with localized scleroderma[J]. J Dermatol, 2015, 42: 283-287. doi:  10.1111/1346-8138.12775
    [2] Distler O, Cozzio A. Systemic sclerosis and localized scleroderma--current concepts and novel targets for therapy[J]. Semin Immunopathol, 2016, 38: 87-95. doi:  10.1007/s00281-015-0551-z
    [3] Careta MF, Romiti R. Localized scleroderma: clinical spectrum and therapeutic update[J]. An Bras Dermatol, 2015, 90: 62-73.
    [4] Peterson LS, Nelson AM, Su WP. Classification of morphea (localized scleroderma)[J]. Mayo Clin Proc, 1995, 70: 1068-1076. doi:  10.4065/70.11.1068
    [5] Valanciene G, Jasaitiene D, Valiukeviciene S. Pathogenesis and treatment modalities of localized scleroderma[J]. Medicina (Kaunas), 2010, 46: 649-656. doi:  10.3390/medicina46100092
    [6] Strong AL, Rubin JP, Kozlow JH, et al. Fat Grafting for the Treatment of Scleroderma[J]. Plast Reconstr Surg, 2019, 144: 1498-1507. doi:  10.1097/PRS.0000000000006291
    [7] Rongioletti F, Ferreli C, Atzori L, et al. Scleroderma with an update about clinico-pathological correlation[J]. G Ital Dermatol Venereol, 2018, 153: 208-215.
    [8] Kreuter A, Krieg T, Worm M, et al. [AWMF Guideline no. 013/066. Diagnosis and therapy of circumscribed scleroderma][J]. J Dtsch Dermatol Ges, 2009, 7: S1-S14.
    [9] Blaszczyk M, Krolicki L, Krasu M, et al. Progressive facial hemiatrophy: central nervous system involvement and relationship with scleroderma en coup de sabre[J]. J Rheumatol, 2003, 30: 1997-2004.
    [10] El-Kehdy J, Abbas O, Rubeiz N. A review of Parry-Romberg syndrome[J]. J Am Acad Dermatol, 2012, 67: 769-784. doi:  10.1016/j.jaad.2012.01.019
    [11] Tollefson MM, Witman PM. En coup de sabre morphea and Parry-Romberg syndrome: a retrospective review of 54 patients[J]. J Am Acad Dermatol, 2007, 56: 257-263. doi:  10.1016/j.jaad.2006.10.959
    [12] Zulian F, Athreya BH, Laxer R, et al. Juvenile localized scleroderma: clinical and epidemiological features in 750 children. An international study[J]. Rheumatology (Oxford), 2006, 45: 614-620. doi:  10.1093/rheumatology/kei251
    [13] Lehman TJ. The Parry Romberg syndrome of progressive facial hemiatrophy and linear scleroderma en coup de sabre. Mistaken diagnosis or overlapping conditions?[J]. J Rheumatol, 1992, 19: 844-845.
    [14] Noh JW, Kim J, Kim JW. Localized scleroderma: a clinical study at a single center in Korea[J]. Int J Rheum Dis, 2013, 16: 437-441. doi:  10.1111/1756-185X.12080
    [15] Wang HC, Dong R, Long X, et al. Aesthetic and therapeutic outcome of fat grafting for localized Scleroderma treatment: From basic study to clinical application[J]. J Cosmet Dermatol, 2021, 20: 2723-2728. doi:  10.1111/jocd.13941
    [16] Gabrielli A, Avvedimento EV, Krieg T. Scleroderma[J]. N Engl J Med, 2009, 360: 1989-2003. doi:  10.1056/NEJMra0806188
    [17] Arkachaisri T, Vilaiyuk S, Li S, et al. The localized scleroderma skin severity index and physician global assessment of disease activity: a work in progress toward development of localized scleroderma outcome measures[J]. J Rheumatol, 2009, 36: 2819-2829. doi:  10.3899/jrheum.081284
    [18] Lis-Święty A, Skrzypek-Salamon A, Ranosz-Janicka I, et al. Associations between Disease Activity/Severity and Damage and Health-Related Quality of Life in Adult Patients with Localized Scleroderma-A Comparison of LoSCAT and Visual Analogue Scales[J]. J Clin Med, 2020, 9: 756. doi:  10.3390/jcm9030756
    [19] Wang HC, Ling S, Wang X, et al. The Development and Initial Validation of PUMC Localized Scleroderma Facial Aesthetic Index: A Pilot Study[J]. Aesthetic Plast Surg, 2021, 45: 1531-1539. doi:  10.1007/s00266-020-02111-4
    [20] 陈波. 脂肪干细胞辅助脂肪移植治疗局限性硬皮病的相关研究[D]. 北京: 北京协和医学院, 2017.
    [21] Jandali S, Mehrara B. Free anterolateral thigh perforator flap in a patient with systemic sclerosis and Raynaud's phenomenon[J]. Plast Reconstr Surg, 2006, 118: 90e-92e. doi:  10.1097/01.prs.0000232388.59236.3a
    [22] Wang TY, Serletti JM, Kolasinski S, et al. A review of 32 free flaps in patients with collagen vascular disorders[J]. Plast Reconstr Surg, 2012, 129: 421e-427e. doi:  10.1097/PRS.0b013e3182412a0b
    [23] Acarturk TO, Maldonado AA, Ereso A. Intraoral reconstruction with "thinned" peroneal artery perforator flaps: An alternative to classic donor areas in comorbid patients[J]. Microsurgery, 2015, 35: 399-402. doi:  10.1002/micr.22366
    [24] Wolff KD, Kesting M, Loffelbein D, et al. Perforator-based anterolateral thigh adipofascial or dermal fat flaps for facial contour augmentation[J]. J Reconstr Microsurg, 2007, 23: 497-503. doi:  10.1055/s-2007-992349
    [25] Terzis JK, Olivares FS. Uses of the superficial temporal fascial flap in facial paralysis[J]. Plast Reconstr Surg, 2008, 122: 176e-185e. doi:  10.1097/PRS.0b013e31818dc012
    [26] Siebert JW, Anson G, Longaker MT. Microsurgical correction of facial asymmetry in 60 consecutive cases[J]. Plast Reconstr Surg, 1996, 97: 354-363. doi:  10.1097/00006534-199602000-00013
    [27] Consorti G, Tieghi R, Clauser LC. Frontal linear scleroderma: long-term result in volumetric restoration of the fronto-orbital area by structural fat grafting[J]. J Craniofac Surg, 2012, 23: e263-e265. doi:  10.1097/SCS.0b013e31824ef7e8
    [28] Lapiere JC, Aasi S, Cook B, et al. Successful correction of depressed scars of the forehead secondary to trauma and morphea en coup de sabre by en bloc autologous dermal fat graft[J]. Dermatol Surg, 2000, 26: 793-797. doi:  10.1046/j.1524-4725.2000.00073.x
    [29] Lee JH, Lim SY, Lee JH, et al. Surgical Management of Localized Scleroderma[J]. Arch Craniofac Surg, 2017, 18: 166-171. doi:  10.7181/acfs.2017.18.3.166
    [30] Zanelato TP, Marquesini G, Colpas PT, et al. Implantation of autologous fat globules in localized scleroderma and idiopathic lipoatrophy--report of five patients[J]. An Bras Dermatol, 2013, 88: 120-123. doi:  10.1590/abd1806-4841.20132115
    [31] Chen B, Wang X, Long X, et al. Supportive Use of Adipose-Derived Stem Cells in Cell-Assisted Lipotransfer for Localized Scleroderma[J]. Plast Reconstr Surg, 2018, 141: 1395-1407. doi:  10.1097/PRS.0000000000004386
    [32] 王阳, 陈波, 王晓军. 自体脂肪移植综合技术矫正面部局限性硬皮病[J]. 组织工程与重建外科杂志, 2016, 12: 34-36. doi:  10.3969/j.issn.1673-0364.2016.01.009

    Wang Y, Chen B, Wang XJ. Application of Autologous Fat Graft in Treating Facial Localized Scleroderma[J]. Zuzhi Gongcheng Yu Chongjian Waike Zazhi, 2016, 12: 34-36. doi:  10.3969/j.issn.1673-0364.2016.01.009
    [33] Wang C, Long X, Si L, et al. A pilot study on ex vivo expanded autologous adipose-derived stem cells of improving fat retention in localized scleroderma patients[J]. Stem Cells Transl Med, 2021, 10: 1148-1156. doi:  10.1002/sctm.20-0419
    [34] Denadai R, Raposo-Amaral CA, Pinho AS, et al. Predictors of Autologous Free Fat Graft Retention in the Management of Craniofacial Contour Deformities[J]. Plast Reconstr Surg, 2017, 140: 50e-61e. doi:  10.1097/PRS.0000000000003440
    [35] Chen W, Xia ZK, Zhang MH, et al. Adipose tissue-derived stem cells ameliorates dermal fibrosis in a mouse model of scleroderma[J]. Asian Pac J Trop Med, 2017, 10: 52-56. doi:  10.1016/j.apjtm.2016.10.005
    [36] Slack GC, Tabit CJ, Allam KA, et al. Parry-Romberg reconstruction: beneficial results despite poorer fat take[J]. Ann Plast Surg, 2014, 73: 307-310. doi:  10.1097/SAP.0b013e31827aeb0d
    [37] Li Y, Zhang W, Gao J, et al. Adipose tissue-derived stem cells suppress hypertrophic scar fibrosis via the p38/MAPK signaling pathway[J]. Stem Cell Res Ther, 2016, 7: 102. doi:  10.1186/s13287-016-0356-6
    [38] Suga H, Eto H, Aoi N, et al. Adipose tissue remodeling under ischemia: death of adipocytes and activation of stem/progenitor cells[J]. Plast Reconstr Surg, 2010, 126: 1911-1923. doi:  10.1097/PRS.0b013e3181f4468b
    [39] Kato H, Mineda K, Eto H, et al. Degeneration, regeneration, and cicatrization after fat grafting: dynamic total tissue remodeling during the first 3 months[J]. Plast Reconstr Surg, 2014, 133: 303e-313e. doi:  10.1097/PRS.0000000000000066
    [40] 王晨羽, 王晓军, 龙笑. 血管化复合同种异体移植的干细胞治疗进展[J]. 中华整形外科杂志, 2021, 37: 692-695.

    Wang CY, Wang XJ, Long X. Stem cell therapy on vas-cular composite allotransplantation[J]. Zhonghua Zheng xing Waike Zazhi, 2021, 37: 692-695.
    [41] Laloze J, Varin A, Gilhodes J, et al. Cell-assisted lipotransfer: Friend or foe in fat grafting? Systematic review and meta-analysis[J]. J Tissue Eng Regen Med, 2018, 12: e1237-e1250.
    [42] Zheng H, Yu Z, Deng M, et al. Fat extract improves fat graft survival via proangiogenic, anti-apoptotic and pro-proliferative activities[J]. Stem Cell Res Ther, 2019, 10: 174. doi:  10.1186/s13287-019-1290-1
    [43] Jeon YR, Roh H, Jung JH, et al. Antifibrotic Effects of High-Mobility Group Box 1 Protein Inhibitor (Glycyrrhizin) on Keloid Fibroblasts and Keloid Spheroids through Reduction of Autophagy and Induction of Apoptosis[J]. Int J Mol Sci, 2019, 20: 4134. doi:  10.3390/ijms20174134
    [44] Kim KK, Sheppard D, Chapman HA. TGF-β1 Signaling and Tissue Fibrosis[J]. Cold Spring Harb Perspect Biol, 2018, 10: a022293. doi:  10.1101/cshperspect.a022293
    [45] Rasmussen BS, Lykke Sorensen C, Vester-Glowinski PV, et al. Effect, Feasibility, and Clinical Relevance of Cell Enrichment in Large Volume Fat Grafting: A Systematic Review[J]. Aesthet Surg J, 2017, 37: S46-S58. doi:  10.1093/asj/sjx008
    [46] Magalon J, Velier M, Simoncini S, et al. Molecular profile and proangiogenic activity of the adipose-derived stromal vascular fraction used as an autologous innovative medicinal product in patients with systemic sclerosis[J]. Ann Rheum Dis, 2019, 78: 391-398. doi:  10.1136/annrheumdis-2018-214218
    [47] Virzi F, Bianca P, Giammona A, et al. Combined platelet-rich plasma and lipofilling treatment provides great improvement in facial skin-induced lesion regeneration for scleroderma patients[J]. Stem Cell Res Ther, 2017, 8: 236. doi:  10.1186/s13287-017-0690-3
    [48] Serratrice N, Bruzzese L, Magalon J, et al. New fat-derived products for treating skin-induced lesions of scleroderma in nude mice[J]. Stem Cell Res Ther, 2014, 5: 138. doi:  10.1186/scrt528
    [49] Daumas A, Magalon J, Delaunay F, et al. Fat Grafting for Treatment of Facial Scleroderma[J]. Clin Plast Surg, 2020, 47: 155-163. doi:  10.1016/j.cps.2019.08.016
    [50] El Atat O, Antonios D, Hilal G, et al. An Evaluation of the Stemness, Paracrine, and Tumorigenic Characteristics of Highly Expanded, Minimally Passaged Adipose-Derived Stem Cells[J]. PLoS One, 2016, 11: e0162332. doi:  10.1371/journal.pone.0162332
    [51] Koh KS, Oh TS, Kim H, et al. Clinical application of human adipose tissue-derived mesenchymal stem cells in progressive hemifacial atrophy (Parry-Romberg disease) with microfat grafting techniques using 3-dimensional computed tomography and 3-dimensional camera[J]. Ann Plast Surg, 2012, 69: 331-337. doi:  10.1097/SAP.0b013e31826239f0
    [52] Tanikawa DY, Aguena M, Bueno DF, et al. Fat grafts supplemented with adipose-derived stromal cells in the rehabilitation of patients with craniofacial microsomia[J]. Plast Reconstr Surg, 2013, 132: 141-152.
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