YU Jiren, WANG E, WANG Difen, CANG Jing, FENG Yi, ZHANG Xijing, YANG Yi, YANG Yunmei, WU Shuijing, WANG Weijian, DU Bin, SHANG You, LIN Ru, CHENG Baoli, XIE Guohao, FANG Xiangming. Expert Consensus on Perioperative Management of Elderly Septic Patients (2021)[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(4): 481-489. DOI: 10.12290/xhyxzz.2021-0312
Citation: YU Jiren, WANG E, WANG Difen, CANG Jing, FENG Yi, ZHANG Xijing, YANG Yi, YANG Yunmei, WU Shuijing, WANG Weijian, DU Bin, SHANG You, LIN Ru, CHENG Baoli, XIE Guohao, FANG Xiangming. Expert Consensus on Perioperative Management of Elderly Septic Patients (2021)[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(4): 481-489. DOI: 10.12290/xhyxzz.2021-0312

Expert Consensus on Perioperative Management of Elderly Septic Patients (2021)

Funds: 

National Key Research and Development Program of China 2018YFC2001904

More Information
  • Corresponding author:

    FANG Xiangming  Tel: 86-571-88208006, E-mail: xmfang@zju.edu.cn

  • Received Date: April 05, 2021
  • Accepted Date: April 28, 2021
  • Issue Publish Date: July 29, 2021
  • As the increasing of the aging population, the number of elderly surgical patients has increased exponentially.In elderly patients, a number of risk factors, such as comorbidities, premedication status, malnutrition, weakness, and impaired function of the immune system (or immune senescence), which are associated with a higher susceptibility to sepsis.These factors not only increase the risk of sepsis, but also lead to more severe manifestations of infection and may be associated with higher mortality.Elderly patients with sepsis had a poor prognosis compared to non-elderly patients, but there was no significant difference in the treatment.In addition, the survivors of elderly septic patients also had poorer quality of life.Therefore, in order to optimize the perioperative management of elderly patients, clinical experts from relevant disciplines discussed this issue and formulated this consensus.
  • [1]
    Shankar-Hari M, Phillips GS, Levy ML, et al. Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (sepsis-3)[J]. JAMA, 2016, 315: 775-787. DOI: 10.1001/jama.2016.0289
    [2]
    Fleischmann-Struzek C, Mellhammar L, Rose N, et al. Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis[J]. Intensive Care Med, 2020, 46: 1552-1562. DOI: 10.1007/s00134-020-06151-x
    [3]
    Shetty AK, Kodali M, Upadhya R, et al. Emerging anti-aging strategies-scientific basis and efficacy[J]. Aging Dis, 2018, 9: 1165-1184. DOI: 10.14336/AD.2018.1026
    [4]
    Martin GS, Mannino DM, Eaton S, et al. The epidemio-logy of sepsis in the United States from 1979 through 2000[J]. N Engl J Med, 2003, 348: 1546-1554. DOI: 10.1056/NEJMoa022139
    [5]
    American Society of Anesthesiologists Task Force on Perioperative Management of patients with obstructive sleep apnea. Practice guidelines for the perioperative management of patients with obstructive sleep apnea: an updated report by the American Society of Anesthesiologists Task Force on perioperative management of patients with obstructive sleep apnea[J]. Anesthesiology, 2014, 120: 268-286. DOI: 10.1097/ALN.0000000000000053
    [6]
    Levy MM, Evans LE, Rhodes A. The Surviving Sepsis Campaign bundle: 2018 update[J]. Crit Care Med, 2018, 46: 997-1000. DOI: 10.1097/CCM.0000000000003119
    [7]
    Yuki K, Murakami N. Sepsis pathophysiology and anes-thetic consideration[J]. Cardiovasc Hematol Disord Drug Targets, 2015, 15: 57-69. DOI: 10.2174/1871529X15666150108114810
    [8]
    Li Y, Chen D, Wang H, et al. Intravenous versus volatile anesthetic effects on postoperative cognition in elderly patients undergoing laparoscopic abdominal surgery[J]. Anesthesiology, 2021, 134: 381-394. DOI: 10.1097/ALN.0000000000003680
    [9]
    Herling SF, Dreijer B, Wrist Lam G, et al. Total intravenous anaesthesia versus inhalational anaesthesia for adults undergoing transabdominal robotic assisted laparoscopic surgery[J]. Cochrane Database Syst Rev, 2017(4): CD011387. http://europepmc.org/abstract/MED/28374886
    [10]
    李佳静, 季方兵, 郑曼, 等. 全凭静脉麻醉与全程吸入麻醉对老年腹部手术患者心脏功能的影响[J]. 临床麻醉学杂志, 2019, 35: 137-140. DOI: 10.12089/jca.2019.02.008

    Li JJ, Ji FB, Zheng M, et al. Effects of all intravenous anesthesia versus total inhalation anesthesia on the cardiac function in elderly patients during intestinal surgery[J]. Linchuang Mazuixue Zazhi, 2019, 35: 137-140. DOI: 10.12089/jca.2019.02.008
    [11]
    Kim S, Brooks AK, Groban L. Preoperative assessment of the older surgical patient: honing in on geriatric syndromes[J]. Clin Interv Aging, 2015, 10: 13-27. http://europepmc.org/abstract/med/25565783
    [12]
    中华医学会麻醉学分会老年人麻醉与围术期管理学组, 国家老年疾病临床医学研究中心, 国家老年麻醉联盟. 中国老年患者围术期麻醉管理指导意见(2020版)(二)[J]. 中华医学杂志, 2020, 100: 2565-2578. DOI: 10.3760/cma.j.cn112137-20200503-01407
    [13]
    吴本俨. 老年人消化系统的衰老改变[J]. 中华老年医学杂志, 2007, 26: 76-78. DOI: 10.3760/j:issn:0254-9026.2007.01.025
    [14]
    Li H, Wang W, Lu YP, et al. Evaluation of endotracheal intubation with a flexible fiberoptic bronchoscope in lateral patient positioning: a prospective randomized controlled trial[J]. Chin Med J (Engl), 2016, 129: 2045-2049. DOI: 10.4103/0366-6999.189069
    [15]
    Eissa D, Carton EG, Buggy DJ. Anaesthetic management of patients with severe sepsis[J]. Br J Anaesth, 2010, 105: 734-743. DOI: 10.1093/bja/aeq305
    [16]
    Naeije G, Pepersack T. Delirium in elderly people[J]. Lancet, 2014, 383: 2044-2045. DOI: 10.1016/S0140-6736(14)60993-4
    [17]
    Heinrich S, Schmidt J, Ackermann A, et al. Comparison of clinical outcome variables in patients with and without etomidate-facilitated anesthesia induction ahead of major cardiac surgery: a retrospective analysis[J]. Crit Care, 2014, 18: R150. DOI: 10.1186/cc13988
    [18]
    McPhee LC, Badawi O, Fraser GL, et al. Single-dose etomidate is not associated with increased mortality in ICU patients with sepsis: analysis of a large electronic ICU database[J]. Crit Care Med, 2013, 41: 774-783. DOI: 10.1097/CCM.0b013e318274190d
    [19]
    Gu WJ, Wang F, Tang L, et al. Single-dose etomidate does not increase mortality in patients with sepsis: a systematic review and meta-analysis of randomized controlled trials and observational studies[J]. Chest, 2015, 147: 335-346. DOI: 10.1378/chest.14-1012
    [20]
    Zausig YA, Busse H, Lunz D, et al. Cardiac effects of induction agents in the septic rat heart[J]. Crit Care, 2009, 13: R144. DOI: 10.1186/cc8038
    [21]
    Kochiyama T, Li X, Nakayama H, et al. Effect of propofol on the production of inflammatory cytokines by human polarized macrophages[J]. Mediators Inflamm, 2019, 2019: 1919538. http://www.ncbi.nlm.nih.gov/pubmed/31007601
    [22]
    Marra EM, Mazer-Amirshahi M, Mullins P, et al. Opioid administration and prescribing in older adults in U.S. emergency departments (2005-2015)[J]. West J Emerg Med, 2018, 19: 678-688. DOI: 10.5811/westjem.2018.5.37853
    [23]
    Pergolizzi J, Böger RH, Budd K, et al. Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step Ⅲ opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone)[J]. Pain Pract, 2008, 8: 287-313. DOI: 10.1111/j.1533-2500.2008.00204.x
    [24]
    Landesberg G, Gilon D, Meroz Y, et al. Diastolic dysfunction and mortality in severe sepsis and septic shock[J]. Eur Heart J, 2012, 33: 895-903. DOI: 10.1093/eurheartj/ehr351
    [25]
    Mouncey PR, Osborn TM, Power GS, et al. Protocolised management in sepsis (ProMISe): a multicentre rando-mised controlled trial of the clinical effectiveness and cost-ef-fectiveness of early, goal-directed, protocolised resuscita-tion for emerging septic shock[J]. Health Technol Assess, 2015, 19: i-xxv, 1-150. http://www.ncbi.nlm.nih.gov/pubmed/26597979
    [26]
    Peake SL, Delaney A, Bailey M, et al. Goal-directed resuscitation for patients with early septic shock[J]. N Engl J Med, 2014, 371: 1496-1506. DOI: 10.1056/NEJMoa1404380
    [27]
    Rowan KM, Angus DC, Bailey M, et al. Early, Goal-directed therapy for septic shock - A patient-level meta-analysis[J]. N Engl J Med, 2017, 376: 2223-2234. DOI: 10.1056/NEJMoa1701380
    [28]
    Perner A, Haase N, Winkel P, et al. Long-term outcomes in patients with severe sepsis randomised to resuscitation with hydroxyethyl starch 130/0.42 or Ringer's acetate[J]. Intensive Care Med, 2014, 40: 927-934. DOI: 10.1007/s00134-014-3311-y
    [29]
    Park CHL, de Almeida JP, de Oliveira GQ, et al. Lactated Ringer's Versus 4% Albumin on Lactated Ringer's in Early Sepsis Therapy in Cancer Patients: A Pilot Single-Center Randomized Trial[J]. Crit Care Med, 2019, 47: e798-e805. DOI: 10.1097/CCM.0000000000003900
    [30]
    De Backer D, Aldecoa C, Njimi H, et al. Dopamine versus norepinephrine in the treatment of septic shock: a meta-analysis[J]. Crit Care Med, 2012, 40: 725-730. DOI: 10.1097/CCM.0b013e31823778ee
    [31]
    Jin Y, Ying J, Zhang K, et al. Endotracheal intubation under video laryngoscopic guidance during upper gastrointestinal endoscopic surgery in the left lateral position: A randomized controlled trial[J]. Medicine (Baltimore), 2017, 96: e9461. DOI: 10.1097/MD.0000000000009461
    [32]
    Fan E, Brodie D, Slutsky AS. Acute respiratory distress syndrome: advances in diagnosis and treatment[J]. JAMA, 2018, 319: 698-710. DOI: 10.1001/jama.2017.21907
    [33]
    Futier E, Marret E, Jaber S. Perioperative positive pressure ventilation: an integrated approach to improve pulmonary care[J]. Anesthesiology, 2014, 121: 400-408. DOI: 10.1097/ALN.0000000000000335
    [34]
    Lescot T, Karvellas C, Beaussier M, et al. Acquired liver injury in the intensive care unit[J]. Anesthesiology, 2012, 117: 898-904. DOI: 10.1097/ALN.0b013e318266c6df
    [35]
    Joannidis M, Druml W, Forni LG, et al. Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017: expert opinion of the working group on prevention, AKI section, European Society of Intensive Care Medicine[J]. Intensive Care Med, 2017, 43: 730-749. DOI: 10.1007/s00134-017-4832-y
    [36]
    Gofton TE, Young GB. Sepsis-associated encephalopathy[J]. Nat Rev Neurol, 2012, 8: 557-566. DOI: 10.1038/nrneurol.2012.183
    [37]
    Rhodes A, Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016[J]. Intensive Care Med, 2017, 43: 304-377. DOI: 10.1007/s00134-017-4683-6
    [38]
    Wang N, Liu X, Zheng X, et al. Ulinastatin is a novel candidate drug for sepsis and secondary acute lung injury, evidence from an optimized CLP rat model[J]. Int Immunopharmacol, 2013, 17: 799-807. DOI: 10.1016/j.intimp.2013.09.004
    [39]
    He QL, Zhong F, Ye F, et al. Does intraoperative ulinastatin improve postoperative clinical outcomes in patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials[J]. Biomed Res Int, 2014, 2014: 630835. http://pubmedcentralcanada.ca/pmcc/articles/PMC3964764/
    [40]
    Karnad DR, Bhadade R, Verma PK, et al. Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: a multicenter randomized controlled study[J]. Intensive Care Med, 2014, 40: 830-838. DOI: 10.1007/s00134-014-3278-8
    [41]
    Pei F, Guan X, Wu J. Thymosin alpha 1 treatment for patients with sepsis[J]. Expert Opin Biol Ther, 2018, 18: 71-76. DOI: 10.1080/14712598.2018.1484104
    [42]
    Liu MW, Wang YH, Qian CY, et al. Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis[J]. Int J Mol Med, 2014, 34: 1492-1504. DOI: 10.3892/ijmm.2014.1943
    [43]
    Yin Q, Li C. Treatment effects of xuebijing injection in severe septic patients with disseminated intravascular coagula-tion[J]. Evid Based Complement Alternat Med, 2014, 2014: 949254.
    [44]
    Zhang Y, Chen H, Li YM, et al. Thymosin alpha1- and ulinastatin-based immunomodulatory strategy for sepsis arising from intra-abdominal infection due to carbapenem-resistant bacteria[J]. J Infect Dis, 2008, 198: 723-730. DOI: 10.1086/590500
    [45]
    Martín S, Pérez A, Aldecoa C. Sepsis and immunosenescence in the elderly patient: a review[J]. Front Med (Lausanne), 2017, 4: 20. http://www.ncbi.nlm.nih.gov/pubmed/28293557
  • Related Articles

    [1]CHEN Weiyun, DAI Yi, QIAN Min, LIANG Jinqian. Perioperative Management of SEPN1-Related Myopathy Accompanying Scoliosis: A Case Report[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2024-0428
    [2]Professional Panel on Injection Aesthetics, National Quality Control Center for Plastic and Aesthetic Surgery. Consensus of Chinese Experts on Neck Injection Aesthetics (2024 Edition)[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(6): 1289-1300. DOI: 10.12290/xhyxzz.2024-0617
    [3]ZHU Di, LUO Xufei, WANG Zijun, SHI Qianling, LI Haodong, WANG Ye, CHEN Yaolong. The Differences and Connections Among Expert Evidence, Expert Opinion and Expert Consensus in the Development of Guidelines[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(4): 936-941. DOI: 10.12290/xhyxzz.2024-0542
    [4]National Center for Quality Assurance of Anesthesia. 2023 Chinese Expert Consensus Statement for Prevention and Management of Perioperative Hypothermia[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 734-743. DOI: 10.12290/xhyxzz.2023-0266
    [5]Joint Surgery Group of Beijing Medical Association Orthopaedic Branch. Expert Consensus on Community Management of Diagnosis and Treatment of Osteoarthritis and Osteoporosis in the Elderly (Version 2023)[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(3): 484-493. DOI: 10.12290/xhyxzz.2022-0699
    [6]Chinese Urological Doctor Association Adrenal Hypertension Surgery Collaborative Organization Adrenal Group, Chinese Society of Endocrinology PET group, Chinese Society of Nuclear Medicine. Consensus on Clinical Application of the CXCR4-targeted Imaging in the Diagnosis of Primary Aldosteronism(2022)[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 986-991. DOI: 10.12290/xhyxzz.2022-0584
    [7]Multi-disciplinary Team for Rare Diseases, Peking Union Medical College Hospital National Rare Diseases Committee. Expert Consensus on Clobazam in the Treatment of Refractory Epilepsy (2022)[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 768-782. DOI: 10.12290/xhyxzz.2022-0421
    [8]LIU Zijia, ZHANG Lu, LIU Hongsheng, CANG Jing, WANG Tianlong, MIN Su, CHEN Lixia, CHEN Wei, LI Shanqing, HUANG Yuguang, Working Group of "Expert Consensus on Prehabilitation Management of Thoracic Surgery", Chinese Society of Anesthesiology. Expert Consensus on Prehabilitation Management for Enhanced Recovery in Patients Undergoing Thoracic Surgery(2022)[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 387-401. DOI: 10.12290/xhyxzz.2022-0178
    [9]Chinese Committee on Antimicrobial Susceptibility Testing, European Committee on Antimicrobial Susceptibility Testing, European Society of Clinical Microbiology and Infectious Diseases, Expert Committee on Infectious Diseases, China Medical Education Association, YANG Qi-wen, MA Xiao-ling, HU Fu-pin, ZHANG Jing, SUN Tong-wen, CHEN Bai-yi, XU Ying-chun, LIU You-ning. Expert Consensus on Polymyxin Antimicrobial Susceptibility Testing and Clinical Interpretation[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(5): 559-570. DOI: 10.3969/j.issn.1674-9081.2020.05.011
    [10]Yao-long CHEN, Xu-fei LUO, Ji-yao WANG, Xiao-qing LIU, Hong-cai SHANG, Ke-hu YANG. How to Distinguish between Clinical Practice Guidelines and Expert Consensus[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(4): 403-408. DOI: 10.3969/j.issn.1674-9081.2019.04.018
  • Cited by

    Periodical cited type(8)

    1. 张浩,代敏,杨柳,李宁香,姜静媛,高永莉. 成人脓毒症患者液体复苏的最佳证据总结. 中华急危重症护理杂志. 2024(07): 662-668 .
    2. 霍昱婷,娄景盛,米卫东. 老年患者非心脏手术术后感染并发症研究现状与进展. 中华老年多器官疾病杂志. 2024(10): 783-786 .
    3. 胥亚,孙杨. 重症脓毒血症患者炎性指标水平与凝血功能的相关性. 吉林医学. 2024(12): 2991-2993 .
    4. 李璐,李宁波. 平均血小板体积与血小板计数比值对脓毒症患者预后的预测价值. 中国药物经济学. 2023(03): 48-51+55 .
    5. 刘宝伟,杨倚天,侯铁柱,张加强. 左侧俯卧位可视化气管插管技术在老年患者ERCP术中的应用. 河南医学研究. 2023(08): 1379-1382 .
    6. 艾司氯胺酮临床应用专家指导意见专家组. 艾司氯胺酮临床应用专家指导意见. 国际麻醉学与复苏杂志. 2023(08): 785-793 .
    7. 侯铁柱,张加强,郑改芳,胡振华,吕素平,刘喆,刘胜群. 左侧卧位下气管插管在食管-胃底静脉曲张出血内镜治疗中应用. 中华实用诊断与治疗杂志. 2022(08): 838-840 .
    8. 吴水晶,娄景盛. 中国老年患者围手术期感染防治的麻醉专家共识. 中华老年多器官疾病杂志. 2022(12): 881-887 .

    Other cited types(6)

Catalog

    Article Metrics

    Article views (1232) PDF downloads (388) Cited by(14)
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return
    x Close Forever Close