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Volume 13 Issue 1
Jan.  2022
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ZHANG Yi, LUO Qin, ZHAO Zhihui, ZHAO Qing, LIU Zhihong. Advances in Ultrasound-assisted Catheter-directed Thrombolysis for the Treatment of Pulmonary Thromboembolism[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(1): 104-109. DOI: 10.12290/xhyxzz.2021-0029
Citation: ZHANG Yi, LUO Qin, ZHAO Zhihui, ZHAO Qing, LIU Zhihong. Advances in Ultrasound-assisted Catheter-directed Thrombolysis for the Treatment of Pulmonary Thromboembolism[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(1): 104-109. DOI: 10.12290/xhyxzz.2021-0029
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Advances in Ultrasound-assisted Catheter-directed Thrombolysis for the Treatment of Pulmonary Thromboembolism

  • Center for Respiratory and Pulmonary Vascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Center for Cardiovascular Disease, Beijing 100037, China

Funds: 

Beijing Municipal Natural Science Foundation 7202168

CAMS Innovation Fund for Medical Sciences 2020-I2M-C & T-B-055

More Information
  • Corresponding author:

    LIU Zhihong, E-mail: zhihongliufuwai@163.com

  • Received Date: January 08, 2021
  • Accepted Date: January 24, 2021
  • Available Online: December 15, 2021
  • Issue Publish Date: January 29, 2022
    Graphical Abstract
    • Abstract
  • Pulmonary thromboembolism(PTE)is the third most common cause of cardiovascular death. However, only about 20% to 30% of patients with high-risk PTE received systemic thrombolysis in real world, due to concerns about the risks such as major bleeding. Although systemic thrombolysis could decrease all-cause mortality of patients with intermediate-risk PTE, the risk of bleeding outweighs the benefits. Ultrasound-assisted catheter-directed thrombolysis (UA-CDT) could directly deliver thrombolytic drugs to the thrombus with lower doses needed. Meanwhile, ultrasound waves could also enhance thrombolysis. Therefore, UA-CDT is emerging as a new tool, with good efficacy and safety records, for the treatment of PTE. In the present review article, we introduce the mechanism, required device, common protocol, efficacy and safety of UA-CDT and discuss directions for future studies.
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    • References (30)
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