Email Alert RSS
Volume 10 Issue 3
Sep.  2020
Turn off MathJax
Article Contents
Abstract
References
Related Articles
Jia-qi ZHANG, Lei LIU, Gui-ge WANG, Wen-liang BAI, Shan-qing LI. Clinical Pathological Features and Prognosis of Non-small Cell Lung Cancer with Skip N2 Lymph Node Metastasis[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(3): 272-277. DOI: 10.3969/j.issn.1674-9081.2019.03.015
Citation: Jia-qi ZHANG, Lei LIU, Gui-ge WANG, Wen-liang BAI, Shan-qing LI. Clinical Pathological Features and Prognosis of Non-small Cell Lung Cancer with Skip N2 Lymph Node Metastasis[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(3): 272-277. DOI: 10.3969/j.issn.1674-9081.2019.03.015
shu

Clinical Pathological Features and Prognosis of Non-small Cell Lung Cancer with Skip N2 Lymph Node Metastasis

  • Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information
  • Corresponding author:

    LI Shan-qing Tel: 86-10-69152630, E-mail: lidanqing@pumch.cn

  • Received Date: December 18, 2018
  • Issue Publish Date: September 17, 2020
    Graphical Abstract
    • Abstract
  • Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the world. The main treatment is surgery intervention, especially for the early-stage of NSCLC. The pathological lymph node metastasis is closely associated with the staging and prognosis of patients. Among N2 metastasis, skip N2 metastasis is a quite common phenomenon with a better prognosis. The aim of this article is to summarize the clinical pathological features and prognosis of NSCLC with skip N2 metastasis and to guide the clinical decision making.
    • FullText(HTML)
    • References (45)
  • [1]
    Detterbeck FC, Nicholson AG, Franklin WA, et al. The IASLC Lung Cancer Staging Project:Summary of Proposals for Revisions of the Classification of Lung Cancers with Multiple Pulmonary Sites of Involvement in the Forthcoming Eighth Edition of the TNM Classification[J]. J Thorac Oncol, 2016, 11:639-650. DOI: 10.1016/j.jtho.2016.01.024
    [2]
    Detterbeck FC, Marom EM, Arenberg DA, et al. The IASLC Lung Cancer Staging Project:Background Data and Proposals for the Application of TNM Staging Rules to Lung Cancer Presenting as Multiple Nodules with Ground Glass or Lepidic Features or a Pneumonic Type of Involvement in the Forthcoming Eighth Edition of the TNM Classification[J]. J Thorac Oncol, 2016, 11:666-680. DOI: 10.1016/j.jtho.2015.12.113
    [3]
    Detterbeck FC, Chansky K, Groome P, et al. The IASLC Lung Cancer Staging Project:Methodology and Validation Used in the Development of Proposals for Revision of the Stage Classification of NSCLC in the Forthcoming (Eighth) Edition of the TNM Classification of Lung Cancer[J]. J Thorac Oncol, 2016, 11:1433-1446. DOI: 10.1016/j.jtho.2016.06.028
    [4]
    Detterbeck FC, Boffa DJ, Kim AW, et al. The Eighth Edition Lung Cancer Stage Classification[J]. Chest, 2017, 151:193-203. DOI: 10.1016/j.chest.2016.10.010
    [5]
    Kirsh MM, Kahn DR, Gago O, et al. Treatment of bronchogenic carcinoma with mediastinal metastases[J]. Ann Thorac Surg, 1971, 12:11. DOI: 10.1016/S0003-4975(10)65088-6
    [6]
    Libshitz HI, McKenna RJ, Mountain CF. Patterns of mediastinal metastases in bronchogenic carcinoma[J]. Chest, 1986, 90:229-232. DOI: 10.1378/chest.90.2.229
    [7]
    Isaka M, Kojima H, Takahashi S, et al. Risk factors for local recurrence after lobectomy and lymph node dissection in patients with non-small cell lung cancer:Implications for adjuvant therapy[J]. Lung Cancer, 2018, 115:28-33. DOI: 10.1016/j.lungcan.2017.11.014
    [8]
    Riquet M, Assouad J, Bagan P, et al. Skip mediastinal lymph node metastasis and lung cancer:a particular N2 subgroup with a better prognosis[J]. Ann Thorac Surg, 2005, 79:225-233. DOI: 10.1016/j.athoracsur.2004.06.081
    [9]
    Benoit L, Anusca A, Ortega-Deballon P, et al. Analysis of risk factors for skip lymphatic metastasis and their prognostic value in operated N2 non-small-cell lung carcinoma[J]. Eur J Surg Oncol, 2006, 32:583-587. DOI: 10.1016/j.ejso.2006.02.004
    [10]
    Misthos P, Sepsas E, Athanassiadi K, et al. Skip metastases:analysis of their clinical significance and prognosis in the IIIA stage of non-small cell lung cancer[J]. Eur J Cardiothorac Surg, 2004, 25:502-508. DOI: 10.1016/j.ejcts.2004.01.025
    [11]
    孟迪. N2淋巴结跳跃性转移在肺癌中的临床特点和预后分析[D].杭州: 浙江大学, 2016. http://cdmd.cnki.com.cn/Article/CDMD-10335-1016283757.htm
    [12]
    Guerrera F, Renaud S, Tabbó F, et al. Epidermal growth factor receptor mutations are linked to skip N2 lymph node metastasis in resected non-small-cell lung cancer adenocarcino-mas[J]. Eur J Cardiothorac Surg, 2017, 51:680-688. DOI: 10.1093/ejcts/ezw362
    [13]
    Li H, Hu H, Wang R, et al. Lung adenocarcinoma:Are skip N2 metastases different from non-skip?[J]. J Thorac Cardiovasc Surg, 2015, 150:790-795. DOI: 10.1016/j.jtcvs.2015.03.067
    [14]
    Li GL, Zhu Y, Zheng W, et al. Analysis of factors influencing skip lymphatic metastasis in pN(2) non-small cell lung cancer[J]. Chin J Cancer Res, 2012, 24:340-345. DOI: 10.1007/s11670-012-0273-x
    [15]
    Sonobe M, Date H, Wada H, et al. Prognostic factors after complete resection of pN2 non-small cell lung cancer[J]. J Thorac Cardiovasc Surg, 2013, 146:788-795. DOI: 10.1016/j.jtcvs.2013.04.043
    [16]
    Takahashi K, Sasaki T, Nabaa B, et al. Pulmonary lymphatic drainage to the mediastinum based on computed tomographic observations of the primary complex of pulmonary histoplasmosis[J]. Acta Radiol, 2012, 53:161-167. DOI: 10.1258/ar.2011.110467
    [17]
    Misthos P, Sepsas E, Kokotsakis J, et al. The significance of one-station N2 disease in the prognosis of patients with nonsmall-cell lung cancer[J]. Ann Thorac Surg, 2008, 86:1626-1630. DOI: 10.1016/j.athoracsur.2008.07.076
    [18]
    Shigemoto Y, Suga K, Matsunaga N. F-18-FDG-avid lymph node metastasis along preferential lymphatic drainage path-ways from the tumor-bearing lung lobe on F-18-FDG PET/CT in patients with non-small-cell lung cancer[J]. Ann Nucl Med, 2016, 30:287-297. DOI: 10.1007/s12149-016-1063-1
    [19]
    Ito M, Yamashita Y, Miyata Y, et al. Prognostic impact of the primary tumor location based on the hilar structures in non-small cell lung cancer with mediastinal lymph node metastasis[J]. Lung Cancer, 2012, 76:93-97. DOI: 10.1016/j.lungcan.2011.07.015
    [20]
    Kawano R, Hata E, Ikeda S, et al. Lobe-specific skip nodal metastasis in non-small cell lung cancer patients[J]. Ann Thorac Cardiovasc Surg, 2008, 14:9-14. https://pubmed.ncbi.nlm.nih.gov/18292733/
    [21]
    Ilic N, Petricevic A, Arar D, et al. Skip mediastinal nodal metastases in the IIIa/N2 non-small cell lung cancer[J]. J Thorac Oncol, 2007:1018-1021. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=WK_LWW2017052520118368
    [22]
    Tanaka F, Takenaka K, Oyanagi H, et al. Skip mediastinal nodal metastases in non-small cell lung cancer[J]. Eur J Cardiothorac Surg, 2004, 25:1114-1120. DOI: 10.1016/j.ejcts.2004.03.001
    [23]
    Casali C, Stefani A, Natali P, et al. Prognostic factors in surgically resected N2 non-small cell lung cancer:the impor-tance of patterns of mediastinal lymph nodes metastases[J]. Eur J Cardiothorac Surg, 2005, 28:33-38. DOI: 10.1016/j.ejcts.2005.03.016
    [24]
    王思愚, 吴一龙, 区伟, 等.非小细胞肺癌纵隔淋巴结跳跃性转移的研究[J].中华肿瘤杂志, 2001, 23:259-261. DOI: 10.3760/j.issn:0253-3766.2001.03.028
    [25]
    Gorai A, Sakao Y, Kuroda H, et al. The clinicopathological features associated with skip N2 metastases in patients with clinical stage IA non-small-cell lung cancer[J]. Eur J Cardiothorac Surg, 2015, 47:653-658. DOI: 10.1093/ejcts/ezu244
    [26]
    Pezzella F, Turley H, Kuzu I, et al. Bcl-2 protein in non-small-cell lung carcinoma[J]. N Engl J Med, 1993, 329:690-694. DOI: 10.1056/NEJM199309023291003
    [27]
    Ohsaki Y, Toyoshima E, Fujiuchi S, et al. bcl-2 and p53 protein expression in non-small cell lung cancers:correlation with survival time[J]. Clin Cancer Res, 1996, 2:915-920. http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_PM9816250
    [28]
    Prenzel KL, Baldus SE, Mönig SP, et al. Skip metastasis in nonsmall cell lung carcinoma[J]. Cancer, 2004, 100:1909-1917. DOI: 10.1002/cncr.20165
    [29]
    Komatsu H, Mizuguchi S, Izumi N, et al. Sialyl Lewis X as a predictor of skip N2 metastasis in clinical stage IA non-small cell lung cancer[J]. World J Surg Oncol, 2013, 11:309. DOI: 10.1186/1477-7819-11-309
    [30]
    Takizawa H, Sakiyama S, Tsuboi M, et al. Demonstration of the skip metastasis pathway for N2 non-small cell lung cancer[J]. J Thorac Cardiovasc Surg, 2014, 147:20022-25223. https://www.sciencedirect.com/science/article/pii/S002252231400035X
    [31]
    Imai K, Minamiya Y, Saito H, et al. Detection of pleural lymph flow using indocyanine green fluorescence imaging in non-small cell lung cancer surgery:a preliminary study[J]. Surg Today, 2013, 43:249-254. DOI: 10.1007/s00595-012-0237-2
    [32]
    Ohta Y, Shimizu Y, Minato H, et al. Results of initial operations in non-small lung cancer patients with single-level N2 disease[J]. Ann Thorac Surg, 2006, 81:427-433. DOI: 10.1016/j.athoracsur.2005.08.018
    [33]
    Goldstraw P, Crowley J, Chansky K, et al. The IASLC Lung Cancer Staging Project:Proposals for the Revision of the TNM Stage Groupings in the Forthcoming (Seventh) Edition of the TNM Classification of Malignant Tumours[J]. J Thorac Oncol, 2007, 2:706-714. DOI: 10.1097/JTO.0b013e31812f3c1a
    [34]
    Yazgan S, Ucvet A, Gursoy S, et al. Single-station skip-N2 disease:good prognosis in resected non-small-cell lung cancer (long-term results in skip-N2 disease)[J]. Interact Cardiovasc Thorac Surg, 2019, 28:247-252. DOI: 10.1093/icvts/ivy244
    [35]
    Akcay O. Skip metastasis in non-small cell lung cancer:does it affect the prognosis?[J]. Turk J Thorac Cardiovasc Surg, 2017, 25:230-234. DOI: 10.5606/tgkdc.dergisi.2017.13168
    [36]
    Gawrychowski J, Gabriel A, Lackowska B. Heterogeneity of stage IIIA non-small cell lung cancers (NSCLC) and evaluation of late results of surgical treatment[J]. Eur J Surg Oncol, 2003, 29:178-184. DOI: 10.1053/ejso.2002.1321
    [37]
    Fukuse T, Hirata T, Naiki H, et al. Prognostic significance of proliferative activity in pN2 non-small-cell lung carcinomas and their mediastinal lymph node metastases[J]. Ann Surg, 2000, 232:112-118. DOI: 10.1097/00000658-200007000-00016
    [38]
    Oyaizu T, Sagawa M, Sato M, et al. The pattern of medias-tinal nodal involvement in lung cancer according to tumor-located lobe[J]. Kyobu Geka, 1999, 52:890-894. http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_PM10513151
    [39]
    Yoshino I, Yokoyama H, Yano T, et al. Skip metastasis to the mediastinal lymph nodes in non-small cell lung cancer[J]. Ann Thorac Surg, 1996, 62:1021-1025. DOI: 10.1016/0003-4975(96)00470-5
    [40]
    Citak N, Sayar A, Metin M, et al. The prognostic signi-ficance of metastasis to lymph nodes in aortopulmonary zone (stations 5 and 6) in completely resected left upper lobe tumors[J]. Thorac Cardiovasc Surg, 2015, 63:568-576. DOI: 10.1055/s-0035-1546463
    [41]
    Cheng X, Zheng D, Li Y, et al. Tumor histology predicts mediastinal nodal status and may be used to guide limited lymphadenectomy in patients with clinical stage I non-small cell lung cancer[J]. J Thorac Cardiovasc Surg, 2018, 155:2648-2656. DOI: 10.1016/j.jtcvs.2018.02.010
    [42]
    张翀.临床Ia期非小细胞肺癌纵隔N2淋巴结跳跃性转移的临床、影像和病理相关因素分析[D].杭州: 浙江大学, 2017. http://cdmd.cnki.com.cn/Article/CDMD-10335-1017119097.htm
    [43]
    李汉忠, 张玉石, 郑国洋.肿瘤免疫治疗:回顾与展望[J].协和医学杂志, 2018, 9:289-294. DOI: 10.3969/j.issn.1674-9081.2018.04.001
    [44]
    Cavallin F, Alfieri R, Scarpa M, et al. Nodal skip metastasis in thoracic esophageal squamous cell carcinoma:a cohort study[J]. BMC Surg, 2017, 17:49. DOI: 10.1186/s12893-017-0247-5
    [45]
    Choi YY, An JY, Guner A, et al. Skip lymph node metas-tasis in gastric cancer:is it skipping or skipped?[J]. Gastric Cancer, 2016, 19:206-215. DOI: 10.1007/s10120-015-0472-5
    • Related Articles

  • Related Articles

    [1]XIE Sining, JIANG Chenguan, LI Xiangjiahui, HAN Ruquan, YANG Zhou, LI Bingxin, SHI Lin. Incidence and Risk Factors of Postoperative Neuropsychiatric Dysfunctions After Deep Brain Stimulation Surgery in Patients with Parkinson's Disease: A Prospective Cohort Study[J]. Medical Journal of Peking Union Medical College Hospital, 2025, 16(2): 300-306. DOI: 10.12290/xhyxzz.2024-0460
    [2]XIAO Chunfeng, WEI Jing. Music Therapy for Mental Disorders: from "Universality" to "Personalization"[J]. Medical Journal of Peking Union Medical College Hospital, 2025, 16(2): 285-291. DOI: 10.12290/xhyxzz.2024-0695
    [3]HUANG Mingtao, LIU Yongxiao, MO Nan. Clinical Ethical Analysis of Informed Consent to Anesthesia in Patients with Mental Disorders[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 437-441. DOI: 10.12290/xhyxzz.2022-0196
    [4]DUAN Yanping, GENG Wenqi, WEI Jing, HONG Xia, SHI Lili, CAO Jinya, LI Tao, JIANG Yinan, ZHAO Xiaohui. Feasibility of Hospitalized Treatment of Inpatients' Mental Disorders in General Hospitals[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 322-327. DOI: 10.12290/xhyxzz.2022-0590
    [5]GENG Wen-qi, DUAN Yan-ping, JIANG Jing, LI Tao, ZHANG Ke-rang, ZHU Gang, YU Xin, SHI Li-li, WEI Jing. Effects of Comorbidity of Generalized Anxiety Disorder on Executive Functions of Patients with Major Depressive Disorder: A Multi-center Retrospective Case-control Study[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(2): 221-226. DOI: 10.3969/j.issn.1674-9081.2020.00.020
    [6]Xi-ya WANG, Cheng ZHEN. Development of Neurology and Psychiatry in Peking Union Medical College Hospital and Contributions of the Foreign Heads of the Division(1921—1941)[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(4): 492-499. DOI: 10.3969/j.issn.1674-9081.2020.04.023
    [7]Shan LI, Hui HUANG, Zuo-jun XU. Common Comorbidities in Patients with Idiopathic Pulmonary Fibrosis[J]. Medical Journal of Peking Union Medical College Hospital, 2018, 9(3): 251-255. DOI: 10.3969/j.issn.1674-9081.2018.03.012
    [9]Na-na XIONG, Xia HONG, Jing JIANG, Xia-yuan SUN, Li-ming ZHU, Guo-qing TIAN, Jing WEI. Physical Illnesses and Psychological Characteristics of Outpatients with Multiple Somatic Symptoms in a General Hospital[J]. Medical Journal of Peking Union Medical College Hospital, 2014, 5(2): 129-134. DOI: 10.3969/j.issn.1674-9081.2014.02.001
    [10]Li-li SHI, Xiao-hui ZHAO, Yi-nan JIANG, Yang XIANG, Li-ming ZHU, Xiu-cai FANG, Shan GAO, Jing WEI. Prevalence of Depressive and Anxiety Disorders in the Peking Union Medical College Hospital and Current Clinical Practice[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(2): 151-154. DOI: 10.3969/j.issn.1674-9081.2011.02.013

  • Cited by

    Periodical cited type(1)

    1. 常林，赵娟，冯红霞，詹晶. 分级心理干预模式对膝关节置换术患者心理及睡眠的影响. 现代医药卫生. 2023(19): 3383-3386 .

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (590) PDF downloads (36) Cited by(1)
    Related
    Links: National Health Commission of the People's Republic of China Chinese Academy of Medical Sciences(CAMS) AMLC Check CNKI Database CNKI Term Online Chinese General Practice
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return
    x Close Forever Close