留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

幽门螺旋杆菌感染与子痫前期的关系

余婷 彭芸花

余婷, 彭芸花. 幽门螺旋杆菌感染与子痫前期的关系[J]. 协和医学杂志, 2020, 11(5): 596-600. doi: 10.3969/j.issn.1674-9081.2020.05.016
引用本文: 余婷, 彭芸花. 幽门螺旋杆菌感染与子痫前期的关系[J]. 协和医学杂志, 2020, 11(5): 596-600. doi: 10.3969/j.issn.1674-9081.2020.05.016
Ting YU, Yun-hua PENG. Relationship between Helicobacter Pylori and Preeclampsia[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(5): 596-600. doi: 10.3969/j.issn.1674-9081.2020.05.016
Citation: Ting YU, Yun-hua PENG. Relationship between Helicobacter Pylori and Preeclampsia[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(5): 596-600. doi: 10.3969/j.issn.1674-9081.2020.05.016

幽门螺旋杆菌感染与子痫前期的关系

doi: 10.3969/j.issn.1674-9081.2020.05.016
详细信息
    通讯作者:

    彭芸花  电话:0931-8356934,E-mail:2008pengyh@163.com

  • 中图分类号: R544.1+5; R573.1

Relationship between Helicobacter Pylori and Preeclampsia

More Information
  • 摘要: 幽门螺旋杆菌是最常见的消化道致病菌,参与急性胃肠炎、消化性溃疡、胃肠肿瘤等胃肠道疾病的发生发展, 与胃肠外疾病也有密切联系。研究发现,幽门螺旋杆菌感染与子痫前期存在明确的流行病学因果关系,特别是细胞毒素相关基因A(cytotoxin-associated gene A, cagA)阳性的幽门螺旋杆菌菌株诱导产生的抗cagA抗体可与滋养层细胞发生免疫反应导致滋养细胞浸润异常。此外,幽门螺旋杆菌感染引起的炎症反应、脂质代谢异常可造成血管内皮功能异常,导致子痫前期。本文将对幽门螺旋杆菌感染与子痫前期的关系作一综述。
    利益冲突  无
  • 表  1  幽门螺旋杆菌感染与子痫前期的相关研究

    第一作者(发表年份) 地区 研究类型 样本量(n) 结局
    Cardaropoli(2011)[8] 意大利 病例对照 Ca:62
    Co:49
    与对照组(42.9%)比较,PE组HP感染比率(85.7%)更高(OR=9.22, 95% CI:2.83~30.04, P<0.001);抗cagA抗体阳性率升高(81.6%比22.4%, OR=17.66, 95% CI:5.25~59.49, P<0.001)
    Ponzetto(2006)[10] 意大利 病例对照 Ca:47
    Co:47
    PE患者HP血清阳性率(51.1%)高于正常孕妇(31.9%)(OR=2.668, 95% CI: 1.084~6.566, P=0.033),cagA阳性率分别为80.9%和14.9%(OR=26.035, 95% CI:8.193~82.729, P<0.001);胎盘组织HP DNA均为阴性
    Ahmed(2020)[11] 苏丹 病例对照 Ca:93
    Co:93
    PE妇女HP阳性率较正常孕妇高(86.0%比55.9%, P<0.001)
    Simone(2017)[12] 意大利 病例对照 Ca:93
    Co:87
    PE妇女HP阳性率较高(57.0%比33.3%, P<0.001);PE妇女中cagA血清阳性率也更高(45.2%比13.7%, P<0.001)
    den Hollander(2016)[13] 荷兰 前瞻性队列 6348 HP阳性率为46%(2915/6348),cagA阳性率为35%(1023/2915),PE发生率为2.0%(129/6348);HP感染与PE有关(OR=1.51, 95% CI:1.03~2.25)
    Elkhouly(2016)[14] 埃及 病例对照 Ca:50
    Co:50
    合并宫内生长迟缓的PE组HP粪便抗原阳性率高于正常妊娠组(76%比32%, P<0.0001)
    Mosbah(2016)[15] 埃及 病例对照 Ca:90
    Co:90
    PE患者HP血清阳性率为54.4%(49/90),高于对照组21.1%(19/90)(P=0.0001)
    Kuo(2014)[16] 台湾 前瞻性队列 346 HP感染率为30.3%(105/346)
    Cardaropoli(2015)[17] 意大利 前瞻性队列 2820 HP血清阳性率为28.5%(804/2820),其中PE患者HP血清阳性率为28.1%(16/57),非PE孕妇HP血清阳性率为28.5%(778/2763)(OR=0.978, 95% CI:0.546~1.753,P=0.941)
    ÜstÜn(2010)[18] 土耳其 病例对照 Ca:40
    Co:40
    PE组HP抗体阳性率为35% (14/40),对照组为12.5%(5/40)(P=0.034);HP阳性者血清C反应蛋白和肿瘤坏死因子-α水平更高
    Aksoy(2010)[19] 土耳其 病例对照 Ca:53
    Co:30
    PE组HP血清阳性率为81%(43/53),正常对照组为60%(18/30)(OR=2.86, 95% CI: 1.05~7.82, P=0.036);HP阳性组血清总胆固醇、低密度脂蛋白胆固醇水平及平均丙二醛浓度高于HP阴性组(P<0.001)
    Pugliese(2008)[20] 意大利 病例对照 Ca:25
    Co:25
    PE患者HP血清阳性率为84%(21/25),正常孕妇为32%(8/25)(P<0.001);PE患者和正常孕妇血清抗cagA抗体阳性率分别为80%(20/25)和28%(7/25)(P<0.001);PE患者和正常孕妇白细胞介素-18水平无明显差异(P=0.23)
    Ca:病例组;Co:对照组;HP:幽门螺旋杆菌;PE:子痫前期;cagA:细胞毒素相关基因A
    下载: 导出CSV
  • [1] Bwj M, Roberts CT, Thangaratinam S, et al. Pre-eclampsia[J]. Lancet, 2016, 387:999-1011. doi:  10.1016/S0140-6736(15)00070-7
    [2] Paauw ND, Luijken K, Franx A, et al. Long-term renal and cardiovascular risk after preeclampsia: Towards screening and prevention[J]. Clin Sci(Lond), 2016, 130:239-246. doi:  10.1042/CS20150567
    [3] Possomato-Vieira JS, Khalil RA. Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia[J]. Adv pharmacol, 2016, 77:361-431. doi:  10.1016/bs.apha.2016.04.008
    [4] Nourollahpour SM, Behboodi MZ, Adam I, et al. Human infectious diseases and risk of preeclampsia: an updated review of the literature[J]. Infection, 2017, 45:589-600. doi:  10.1007/s15010-017-1031-2
    [5] 姚敏, 李艳梅.根除幽门螺杆菌四联疗法对胃肠道微生态的影响[J].协和医学杂志, 2019, 10(3):268-271. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xhyx201903015
    [6] Zamani M, Ebrahimtabar F, Zamani V, et al. Systematic review with meta-analysis: the worldwide prevalence of Helicobacter pylori infection[J]. Aliment Pharmacol Ther, 2018, 47:868-876. doi:  10.1111/apt.14561
    [7] Nejati S, Karkhah A, Darvish H, et al. Influence of Helicobacter pylori virulence factors CagA and VacA on pathogen-esis of gastrointestinal disorders[J]. Microb Pathog, 2018, 117:43-48. doi:  10.1016/j.micpath.2018.02.016
    [8] Cardaropoli S, Rolfo A, Piazzese A, et al. Helicobacter pylori's virulence and infection persistence define pre-eclampsia complicated by fetal growth retardation[J]. World J Gastroenterol, 2011, 17:5156-5165. doi:  10.3748/wjg.v17.i47.5156
    [9] Zhan YL, Si MY, Li MS, et al. The risk of Helicobacter pylori infection for adverse pregnancy outcomes: A systematic review and meta analysis[J]. Helicobacter, 2019, 24:e12562. doi:  10.1111/hel.12562
    [10] Ponzetto A, Cardaropoli S, Piccoli E, et al. Pre-eclampsia is associated with Helicobacter pylori seropositivity in Italy[J]. J Hypertens, 2006, 24:2445-2449. doi:  10.1097/HJH.0b013e3280109e8c
    [11] Ahmed MA, Hassan NG, Omer ME, et al. Helicobacter pylori and Chlamydia trachomatis in Sudanese women with preeclampsia[J]. J Mater Fetal Neonatal Med, 2020, 33:2023-2026. doi:  10.1080/14767058.2018.1536738
    [12] Simone ND, Tersigni C, Cardaropoli S, et al. Helicobacter pylori infection contributes to placental impairment in preeclampsia: basic and clinical evidences[J]. Helicobacter, 2017, 22:e12347. doi:  10.1111/hel.12347
    [13] den Hollander WJ, Schalekamp-Timmermans S, Holster IL, et al. Helicobacter pylori colonization and pregnancies complicated by preeclampsia, spontaneous prematurity, and small for gestational age birth[J]. Helicobacter, 2016, 22:e12364. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=10.1111/hel.12364
    [14] Elkhouly NI, Elkelani OA, Elhalaby AF, et al. Relation between Helicobacter pylori infection and severe pre-eclampsia complicated by intrauterine growth restriction in a rural area in Egyp[J]. J Obstet Gynaecol, 2016, 36:1046-1049. doi:  10.1080/01443615.2016.1196169
    [15] Mosbah A, Nabiel Y. Helicobacter pylori, Chlamydiae pneumoniae and trachomatis as probable etiological agents of preeclampsia[J]. J Mater Fetal Neonatal Med, 2016, 29:1607-1612. doi:  10.3109/14767058.2015.1056146
    [16] Kuo FC, Wu CY, Kuo CH, et al. The Utilization of a New Immunochromatographic Test in Detection of Helicobacter pylori Antibody from Maternal and Umbilical Cord Serum[J]. Biomed Res Int, 2014, 2014:568410. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=Doaj000003930533
    [17] Cardaropoli S, Giuffrida D, Piazzese A, et al. Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study[J]. J Reprod Immunol, 2015, 109:41-47. doi:  10.1016/j.jri.2015.02.004
    [18] ÜstÜn Y, Engin-ÜstÜn Y, Özkaplan E, et al. Association of Helicobacter pylori infection with systemic inflammation in preeclampsia[J]. J Matern Fetal Med, 2010, 23:311-314. doi:  10.3109/14767050903121456
    [19] Aksoy H, Ozkan A, Aktas F, et al. Helicobacter pylori seropositivity and its relationship with serum malondialdehyde and lipid profile in preeclampsia[J]. J Clin Lab Anal, 2010, 23:219-222.
    [20] Pugliese A, Beltramo T, Todros T, et al. Interleukin-18 and gestosis: correlation with Helicobacter pylori seropositivity[J]. Cell Biochemi Funct, 2008, 26:817-819. doi:  10.1002/cbf.1503
    [21] Bellos I, Daskalakis G, Pergialiotis V. Helicobacter pylori infection increases the risk of developing preeclampsia: A meta-analysis of observational studies[J]. Int J Clin Pract, 2018, 72:e13064. doi:  10.1111/ijcp.13064
    [22] Nourollahpour SM, Mohammad RS, Adam I, et al. Helicobacter pylori infection and risk of preeclampsia: a systematic review and meta-analysis[J]. J Matern Fetal Neonatal Med, 2019, 32:324-331. doi:  10.1080/14767058.2017.1378331
    [23] 郭晗, 张云聪, 杨硕, 等.子痫前期发病机制的研究进展[J].临床检验杂志, 2018, 36:439-443. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=lcjyzz201806011
    [24] Franceschi F, Di Simone N, D'Ippolito S, et al. Antibodies anti-caga cross-react with trophoblast cells: a risk factor for pre-eclampsia?[J]. Helicobacter, 2012, 17:426-434. doi:  10.1111/j.1523-5378.2012.00966.x
    [25] Qadri Q, Rasool R, Gulzar GM, et al. H. pyloriInfection, Inflammation and Gastric Cancer[J]. J Gastrointest Cancer, 2014, 45:126-132. doi:  10.1007/s12029-014-9583-1
    [26] Buzás GM. Metabolic consequences of Helicobacter pylori infection and eradication[J]. World J Gastroenterol, 2014, 20:5226-5234. doi:  10.3748/wjg.v20.i18.5226
    [27] Adachi K, Mishiro T, Toda T, et al. Effects of Helicobacter pylori eradication on serum lipid levels[J]. J Clin Biochem Nutr, 2018, 62:264-269. doi:  10.3164/jcbn.17-88
    [28] 王广娇, 杨孜.脂代谢和脂肪酸代谢与子痫前期[J].中国实用妇科与产科杂志, 2018, 34:18-22. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgsyfkyckzz201809005
    [29] Adank MC, Benschop L, Peterbroers KR, et al. Is maternal lipid profile in early pregnancy associated with pregnancy complications and blood pressure in pregnancy and long-term postpartum?[J]. Am J Obstet Gynecol, 2019, 221:150.e1-150.e13. doi:  10.1016/j.ajog.2019.03.025
    [30] Riise HKR, Sulo G, Tell GS, et al. Hypertensive pregnancy disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors[J]. Int J Cardiol, 2019, 282:81-87. doi:  10.1016/j.ijcard.2019.01.097
    [31] Veerbeek JHW, Hermes W, Breimer AY, et al. Cardiovascular disease risk factors after early-onset preeclampsia, late-onset preeclampsia, and pregnancy-induced hypertension[J]. Hypertension, 2015, 65:600-606. doi:  10.1161/HYPERTENSIONAHA.114.04850
    [32] Alsnes IV, Vatten LJ, Fraser A, et al. Hypertension in Pregnancy and Offspring Cardiovascular Risk in Young Adulthood Novelty and Significance[J]. Hypertension, 2017, 69:591-598. doi:  10.1161/HYPERTENSIONAHA.116.08414
    [33] Davi G, Neri M, Falco A, et al. Helicobacter pylori infection causes persistent platelet activation in vivo through enhanced lipid peroxidation[J]. Arteriosclerosis Thromb Vasc Biol, 2005, 25:246-251. doi:  10.1161/01.ATV.0000147128.10278.99
    [34] Franceschi F, Niccoli G, Ferrante G, et al. CagA antigen of Helicobacter pylori and coronary instability: insight from a clinico-pathological study and a meta-analysis of 4241 cases[J]. Atherosclerosis, 2009, 202:535-542. doi:  10.1016/j.atherosclerosis.2008.04.051
  • 加载中
表(1)
计量
  • 文章访问数:  312
  • HTML全文浏览量:  45
  • PDF下载量:  15
  • 被引次数: 0
出版历程
  • 收稿日期:  2019-08-29
  • 刊出日期:  2020-09-30

目录

    /

    返回文章
    返回

    【温馨提醒】近日,《协和医学杂志》编辑部接到作者反映,有多名不法人员冒充期刊编辑发送见刊通知,鼓动作者添加微信,从而骗取版面费的行为。特提醒您,本刊与作者联系的方式均为邮件通知或电话,稿件进度通知邮箱为:mjpumch@126.com,编辑部电话为:010-69154261,请提高警惕,谨防上当受骗!如有任何疑问,请致电编辑部核实。谢谢!