邮件订阅 RSS

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

硼中子俘获疗法的原理及临床应用

刘志凯,  程炜诗,  吴王锁,  梁天骄,  邢庆子,  张紫竹,  刘志博,  刘渊豪,  潘建基,  朱晒红,  李晴暖,  张福泉,  邱杰,  霍力

downloadPDF
文章导航 > 协和医学杂志  > 优先出版
刘志凯, 程炜诗, 吴王锁, 梁天骄, 邢庆子, 张紫竹, 刘志博, 刘渊豪, 潘建基, 朱晒红, 李晴暖, 张福泉, 邱杰, 霍力. 硼中子俘获疗法的原理及临床应用[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2023-0120
引用本文: 刘志凯, 程炜诗, 吴王锁, 梁天骄, 邢庆子, 张紫竹, 刘志博, 刘渊豪, 潘建基, 朱晒红, 李晴暖, 张福泉, 邱杰, 霍力. 硼中子俘获疗法的原理及临床应用[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2023-0120
shu
LIU Zhikai, CHENG Weishi, WU Wangsuo, LIANG Tianjiao, XING Qingzi, ZHANG Zizhu, LIU Zhibo, LIU Yuanhao, PAN Jianji, ZHU Shaihong, LI Qingnuan, ZHANG Fuquan, QIU Jie, HUO Li. Principles and Clinical Applications of Boron Neutron Capture Therapy[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2023-0120
Citation: LIU Zhikai, CHENG Weishi, WU Wangsuo, LIANG Tianjiao, XING Qingzi, ZHANG Zizhu, LIU Zhibo, LIU Yuanhao, PAN Jianji, ZHU Shaihong, LI Qingnuan, ZHANG Fuquan, QIU Jie, HUO Li. Principles and Clinical Applications of Boron Neutron Capture Therapy[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2023-0120
shu

硼中子俘获疗法的原理及临床应用

doi: 10.12290/xhyxzz.2023-0120

  • 1 中国医学科学院北京协和医院 放射治疗科, 北京 100730;

  • 2 中国医学科学院北京协和医院 核医学科, 北京 100730;

  • 3 兰州大学核科学与技术学院, 兰州 730000;

  • 4 中国科学院高能物理研究所, 广东东莞 100049;

  • 5 清华大学工程物理系, 北京 100084;

  • 6 北京核工业医院, 北京 100045;

  • 7 北京大学化学与分子工程学院, 北京 100871;

  • 8 中硼(厦门)医疗器械有限公司, 厦门 361028;

  • 9 福建医科大学, 福州 350122;

  • 10 中南大学湘雅三医院, 长沙 410013;

  • 11 中国科学院上海应用物理研究所, 上海 201800

详细信息

  • 中图分类号: R45;R73

Principles and Clinical Applications of Boron Neutron Capture Therapy

  • 1 Department of Radiotherapy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China;

  • 2 Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China;

  • 3 School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000, China;

  • 4 Institute of High Energy Physics, Chinese Academy of Sciences, Dongguan 100049, China;

  • 5 Department of Engineering Physics, Tsinghua University, Beijing 100084. China;

  • 6 Beijing Nuclear Industry Hospital, Beijing 100045, China;

  • 7 School of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;

  • 8 China Boron(Xiamen) Medical Devices Co., Ltd., Xiamen 361028, China;

  • 9 Fujian Medical University, Fuzhou 350122, China;

  • 10 The third Xiangya Hospital of Central South University, Changsha 410013, China;

  • 11 Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

    摘要
  • 摘要: 硼中子俘获疗法（ Boron neutron capture therapy,BNCT）是一项处于快速发展中的先进放疗技术。该技术通过在癌细胞内发生的10B (n,α)7Li原子核反应杀死癌细胞，是一种原子级别的二元靶向治疗，其临床实施需要专业技术与装置支持。BNCT的核心要素包括适宜的中子源及中子俘获药物。相较于传统放疗技术，BNCT在治疗局部复发肿瘤（如中枢神经系统肿瘤和头颈部肿瘤）中优势突出，能够更好地保护正常器官，特别是对于已经对周围器官产生明显侵犯的肿瘤具有良好的应用前景。本文主要阐述BNCT的技术原理、核心要素及其临床应用，以期为临床诊疗提供参考。
    Abstract: Boron neutron capture therapy (BNCT) is an advanced radiation therapy technique that is rapidly developing in the field of cancer treatment. This technique kills cancer cells by causing a 10B(n,α)7Li nuclear reaction within the cancer cells, which is an atomic-level binary targeted therapy, and its clinical implementation requires professional technology and device support. The core elements of BNCT include appropriate neutron sources and neutron capture drugs. The clinical implementation of BNCT also requires corresponding technologies and devices. Compared with traditional radiotherapy techniques, BNCT shows outstanding advantages in treating locally recurrent tumors, such as central nervous system tumors and head and neck tumors, and can better protect normal organs, especially for tumors that have already significantly invaded surrounding organs, demonstrating its promising future prospects. This article mainly elaborates on the technical principles, core elements, and clinical applications of BNCT, in order to provide reference for clinical diagnosis and treatment.
    • HTML全文
    • 参考文献(44)
  • [1] Taylor HJ, Goldhaber M. Detection of Nuclear Disintegration in a Photographic Emulsion[J]. Nature, 1935, 135:341-341.
    [2] 关兴彩. 0.5eV到数百keV能区中子通量密度监测器的理论设计与实验研究[D]. 兰州:兰州大学, 2016.
    [3] Kankaanranta L, Seppälä T, Koivunoro H, et al. Boron neutron capture therapy in the treatment of locally recurred head-and-neck cancer:final analysis of a phase I/II trial[J]. Int J Radiat Oncol Biol Phys, 2012, 82:e67-e75.
    [4] Kasesaz Y, Khalafi H, Rahmani F. Optimization of the beam shaping assembly in the D-D neutron generators-based BNCT using the response matrix method[J]. Appl Radiat Isot, 2013, 82:55-59.
    [5] Kasesaz Y, Rahmani F, Khalafi H. Investigation on the reflector/moderator geometry and its effect on the neutron beam design in BNCT[J]. Appl Radiat Isot, 2015, 106:34-37.
    [6] Barth RF, Vicente MGH, Harling OK, et al. Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer[J]. Radiat Oncol, 2012, 7:146.
    [7] Kasesaz Y, Khalafi H, Rahmani F, et al. A feasibility study of the Tehran research reactor as a neutron source for BNCT[J]. Appl Radiat Isot, 2014, 90:132-137.
    [8] Durisi E, Alikaniotis K, Borla O, et al. Design and simulation of an optimized elinac based neutron source for BNCT research[J]. Appl Radiat Isot, 2015, 106:63-67.
    [9] Rahmani F, Seifi S, Anbaran HT, et al. Design of photon converter and photoneutron target for High power electron accelerator based BNCT[J]. Appl Radiat Isot, 2015, 106:45-48.
    [10] Skalyga V, Izotov I, Golubev S, et al. Neutron generator for BNCT based on high current ECR ion source with gyrotron plasma heating[J]. Appl Radiat Isot, 2015, 106:29-33.
    [11] Sumita K, Takahashi A, Iida T, et al. Status of OKTAVIAN I and proposal for OKTAVIAN II[J]. Nuclear Science and Engineering, 1990, 106:249-265.
    [12] Barth RF, Mi P, Yang W. Boron delivery agents for neutron capture therapy of cancer[J]. Cancer Commun (Lond), 2018, 38:35.
    [13] Hu K, Yang Z, Zhang L, et al. Boron agents for neutron capture therapy[J]. Coordination Chemistry Reviews, 2020, 405:213139.
    [14] Farr LE, Sweet WH, Robertson JS, et al. Neutron capture therapy with boron in the treatment of glioblastoma multiforme[J]. Am J Roentgenol Radium Ther Nucl Med, 1954, 71:279-293.
    [15] Goodwin JT, Farr LE, Sweet WH, et al. Pathological study of eight patients with glioblastoma multiforme treated by neutron-capture therapy using boron 10[J]. Cancer, 1955, 8:601-615.
    [16] Sweet WH, Javid M. The possible use of neutron-capturing isotopes such as boron 10 in the treatment of neoplasms. I. Intracranial tumors[J]. J Neurosurg, 1952, 9:200-209.
    [17] Asbury AK, Ojemann RG, Nielsen SL, et al. Neuropathologic study of fourteen cases of malignant brain tumor treated by boron-10 slow neutron capture radiation[J]. J Neuropathol Exp Neurol, 1972, 31:278-303.
    [18] Mishima Y, Ichihashi M, Hatta S, et al. First human clinical trial of melanoma neutron capture. Diagnosis and therapy[J]. Strahlenther Onkol, 1989, 165:251-254.
    [19] Kankaanranta L, Seppälä T, Koivunoro H, et al. L-boronophenylalanine-mediated boron neutron capture therapy for malignant glioma progressing after external beam radiation therapy:a Phase I study[J]. Int J Radiat Oncol Biol Phys, 2011, 80:369-376.
    [20] Soloway AH, Hatanaka H, Davis MA. Penetration of brain and brain tumor. VII. Tumor-binding sulfhydryl boron compounds[J]. J Med Chem, 1967, 10:714-717.
    [21] Hatanaka H, Nakagawa Y. Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy[J]. Int J Radiat Oncol Biol Phys, 1994, 28:1061-1066.
    [22] Nakagawa Y, Pooh K, Kobayashi T, et al. Clinical review of the Japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams[J]. J Neurooncol, 2003, 62:87-99.
    [23] Evangelista L, Jori G, Martini D, et al. Boron neutron capture therapy and 18Flabelled borophenylalanine positron emission tomography:a critical and clinical overview of the literature[J]. Appl Radiat Isot, 2013, 74:91-101.
    [24] Ishiwata K. 4-Borono-2-18F-fluoro-L-phenylalanine PET for boron neutron capture therapy-oriented diagnosis:overview of a quarter century of research[J]. Ann Nucl Med, 2019, 33:223-236.
    [25] 龚春慧. 硼中子俘获治疗中硼浓度在线实时监测系统关键技术研究[D]. 南京:南京航空航天大学, 2018.
    [26] Diaz AZ. Assessment of the results from the phase I/II boron neutron capture therapy trials at the Brookhaven National Laboratory from a clinician's point of view[J]. J Neurooncol, 2003, 62:101-109.
    [27] Matsumura A, Yamamoto T, Tsurubuchi T, et al. Current practices and future directions of therapeutic strategy in glioblastoma:survival benefit and indication of BNCT[J]. Appl Radiat Isot, 2009, 67:S12-S14.
    [28] Kageji T, Nagahiro S, Mizobuchi Y, et al. Boron neutron capture therapy (BNCT) for newly-diagnosed glioblastoma:comparison of clinical results obtained with BNCT and conventional treatment[J]. J Med Invest, 2014, 61:254-263.
    [29] Kawabata S, Miyatake SI, Nonoguchi N, et al. Survival benefit from boron neutron capture therapy for the newly diagnosed glioblastoma patients[J]. Appl Radiat Isot, 2009, 67:S15-S18.
    [30] Kawabata S, Suzuki M, Hirose K, et al. Accelerator-based BNCT for patients with recurrent glioblastoma:a multicenter phase II study[J]. Neurooncol Adv, 2021, 3:vdab067.
    [31] Takeuchi K, Kawabata S, Hiramatsu R, et al. Boron Neutron Capture Therapy for High-Grade Skull-Base Meningioma[J]. J Neurol Surg B Skull Base, 2018, 79:S322-S327.
    [32] Suzuki M, Kato I, Aihara T, et al. Boron neutron capture therapy outcomes for advanced or recurrent head and neck cancer[J]. J Radiat Res, 2014, 55:146-153.
    [33] Kato I, Fujita Y, Maruhashi A, et al. Effectiveness of boron neutron capture therapy for recurrent head and neck malignancies[J]. Appl Radiat Isot, 2009, 67:S37-S42.
    [34] Kato T, Hirose K, Tanaka H, et al. Design and construction of an accelerator-based boron neutron capture therapy (AB-BNCT) facility with multiple treatment rooms at the Southern Tohoku BNCT Research Center[J]. Appl Radiat Isot, 2020, 156:108961.
    [35] Menéndez PR, Roth BMC, Pereira MD, et al. BNCT for skin melanoma in extremities:updated Argentine clinical results[J]. Appl Radiat Isot, 2009, 67:S50-S53.
    [36] Yong Z, Song Z, Zhou Y, et al. Boron neutron capture therapy for malignant melanoma:first clinical case report in China[J]. Chin J Cancer Res, 2016, 28:634-640.
    [37] Suzuki M, Endo K, Satoh H, et al. A novel concept of treatment of diffuse or multiple pleural tumors by boron neutron capture therapy (BNCT)[J]. Radiother Oncol, 2008, 88:192-195.
    [38] Seneviratne D, Advani P, Trifiletti DM, et al. Exploring the Biological and Physical Basis of Boron Neutron Capture Therapy (BNCT) as a Promising Treatment Frontier in Breast Cancer[J]. Cancers (Basel), 2022, 14:3009.
    [39] Wei Q, Kullberg EB, Gedda L. Trastuzumab-conjugated boron-containing liposomes for tumor-cell targeting; development and cellular studies[J]. Int J Oncol, 2003, 23:1159-1165.
    [40] Gadan MA, González SJ, Batalla M, et al. Application of BNCT to the treatment of HER2+ breast cancer recurrences:Research and developments in Argentina[J]. Appl Radiat Isot, 2015, 104:155-159.
    [41] Futamura G, Kawabata S, Siba H, et al. A case of radiation-induced osteosarcoma treated effectively by boron neutron capture therapy[J]. Radiat Oncol, 2014, 9:237.
    [42] Fujimoto T, Andoh T, Sudo T, et al. Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST)[J]. Appl Radiat Isot, 2015, 106:220-225.
    [43] Hiratsuka J, Kamitani N, Tanaka R, et al. Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget's disease with curative responses[J]. Cancer Commun (Lond), 2018, 38:38.
    [44] Nakagawa Y, Kageji T, Mizobuchi Y, et al. Clinical results of BNCT for malignant brain tumors in children[J]. Appl Radiat Isot, 2009, 67:S27-S30.
    • 相关文章
    • 施引文献
  • 资源附件(0)
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  49
  • HTML全文浏览量:  2
  • PDF下载量:  19
  • 被引次数: 0
出版历程
  • 收稿日期:  2023-03-10
  • 网络出版日期:  2023-04-10

目录

    /

    返回文章
    返回
    友情链接: 国家卫生健康委员会 北京协和医院 中国医学科学院 学术不端检测系统 国际知识资源总库 中国知网 术语在线 中国全科医学
    地址：北京市东城区帅府园1号 北京协和医院老楼7号楼
    3层302室 《协和医学杂志》编辑部
    电话：010-69154261/4262
    E - mail：medj@pumch.cn
    mjpumch@126.com
    期刊网站版权所有：《协和医学杂志》编辑部
    京ICP备 11002662

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计

    x 关闭 永久关闭

    【温馨提醒】近日，《协和医学杂志》编辑部接到作者反映，有多名不法人员冒充期刊编辑发送见刊通知，鼓动作者添加微信，从而骗取版面费的行为。特提醒您，本刊与作者联系的方式均为邮件通知或电话，稿件进度通知邮箱为：mjpumch@126.com，编辑部电话为：010-69154261，请提高警惕，谨防上当受骗！如有任何疑问，请致电编辑部核实。谢谢！