Abstract: Systemic lupus erythematosus(SLE) is a disease with a high incidence in women of childbearing age, especially 20-40 years old. Most patients at this age will have the need for pregnancy. However, when SLE combines with pregnancy, pregnant women are facing not only the risk of relapse and aggravation of lupus, but also the increased risk of adverse pregnancies. Therefore, it is very important to do well in the comprehensive management of pregnancy in SLE patients. This paper focused on the interaction between SLE and pregnancy, as well as the management of SLE in pregnant patients, aiming to better understand and improve the pregnancy outcome of SLE patients.