Abstract: In recent years, vascular interventional therapy has been widely used in clinical practice due to its less trauma, better curative effect and faster recovery. However, traditional vascular interventional therapy is often guided by radiology such as digital subtraction angiography, which is not suitable for patients with iodine contrast agent allergy or contraindications. Ultrasound-guided vascular interventional therapy can avoid the above defects, and it is low-cost and convenient. At present, this technique is mainly used in the minimally invasive treatment of arterial stenosis or occlusion of the lower extremity, renal artery stenosis, abdominal aortic aneurysm, iatrogenic pseudoaneurysm, Budd-Chiari syndrome, walnut clip syndrome, left iliac vein compression syndrome, great saphenous varicose vein, venous malformation, inferior vena cava filter implantation, catheter contact thrombolization, and so on. The basis and key to the success of the treatment is that the conventional ultrasound image can clearly display the operating pathway and lesion area, and maintain image stability. At the same time, the guidewire and balloon and other intravascular operating instruments can be dis-played clearly on the ultrasound image in real time. Ultrasound-guided vascular interventional therapy can also evaluate the vascular segment of the lesion and estimate the effect of interventional therapy in real time. In addition, intravascular ultrasound can more intuitively display the internal structure of blood vessels, so that the difficult operation guided by conventional ultrasound intervention can be successfully carried out, which broadens the field of ultrasound interventional therapy.