LCN2在神经系统疾病中作用机制研究进展

Research Progress on the Mechanism of Lipocalin-2 in Neurological Diseases

  • 摘要: 脂质运载蛋白2( lipocalin-2,LCN2)是人脂质运载蛋白家族的一员,已被证明与糖尿病、心血管疾病、肾脏疾病存在密切关联。近年来研究表明,LCN2通过介导炎症、氧化应激反应、铁死亡等路径在多种神经系统疾病的发生发展中发挥重要调节作用。本文从脑血管疾病、认知障碍性疾病、帕金森病、抑郁症及焦虑症等方面,阐述LCN2在神经系统疾病中作用的研究进展,以期加深临床的认知。

     

    Abstract: Lipocalin-2 (LCN2), a member of the human lipocalin family, has been demonstrated to be closely associated with diabetes, cardiovascular diseases, and renal disorders. Recent studies have indicated that LCN2 plays a significant regulatory role in the pathogenesis and progression of various neurological diseases by mediating pathways such as inflammation, oxidative stress, and ferroptosis.This article reviews the research advancements on the role of LCN2 in neurological disorders, including cerebrovascular diseases, cognitive impairment disorders, Parkinson's disease, depression, and anxiety disorders, aiming to enhance clinical understanding.

     

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