Abstract: Obesity serves as a significant contributing factor to various chronic diseases, and standardized and systematic clinical management is crucial for enhancing overall health outcomes. Currently, there is a lack of comprehensive and authoritative guidelines for the diagnosis and treatment of obesity. This guideline, grounded in existing high-quality evidence-based medical literature, integrates multidisciplinary expert consensus and extensively solicits expert opinions. It systematically addresses the etiology, epidemiology, definition, diagnostic criteria, treatment principles, and multidisciplinary collaborative care models for obesity. The objective is to standardize the clinical management of obesity in China and effectively guide healthcare professionals across various medical institutions. Furthermore, this guideline will be continuously updated and refined based on emerging clinical evidence.