Abstract: Obesity serves as a significant contributing factor to various chronic diseases, so standardized and systematic clinical management of obesity is crucial for enhancing overall health outcomes. Currently, there is a lack of comprehensive and authoritative guidelines for the diagnosis and treatment of obesity. Based on existing high-quality evidence-based medical literature, this guideline, by integrating multidisciplinary expert opinions, systematically addresses the etiology, epidemiology, definition, diagnostic criteria, treatment principles, and multi-disciplinary treatment models for obesity. Its objective is to standardize the clinical management of obesity in China and effectively guide healthcare professionals across various medical institutions. Furthermore, this guideline will be continually updated and refined based on emerging clinical evidence.