Abstract: Organ transplantation, as a therapeutic option for children with end-stage organ failure, has seen continuous improvement in surgical techniques, organ preservation methods, and immunosuppressive drugs, leading to enhanced surgical success rates and long-term quality of life for recipients. Initially focused on heart and lung transplants in pediatric recipients, extracorporeal membrane oxygenation (ECMO) application has expanded to provide support for cardiopulmonary complications occurring during abdominal organ transplants such as liver and kidney, as well as for the maintenance of donor organs. With the ongoing advancements in ECMO technology and equipment, its significance in supporting therapy for end-stage organ failure in children is becoming increasingly prominent, granting a new lease on life to more children facing organ failure.