Abstract: Plateau refractory wounds are affected by adverse conditions such as hypoxia, strong ultraviolet rays, and frigid, which can cause serious cell function damage, hinder reepithelialization, and delay or even non-healing of wounds. Conventional debridement and drainage, functional dressings and other traditional treatments have poor efficacy. Not only do patients have long hospital stays, but they may also suffer from other complications due to longterm non-healing of wounds. In this paper, we report a patient with a plateau refractory wound that had not healed for 2 months. After two treatments with platelet lysate gel, the wound healed completely. This treatment method provides a new treatment idea for patients with plateau refractory wounds, which is worthy of clinical reference.