幽门螺杆菌诱导上皮-间质转化在胃癌中的作用机制

Mechanism of Epithelial-mesenchymal Transition Leading to Gastric Cancer Induced by Helicobacter pylori

摘要: 幽门螺杆菌(Helicobacter pylori, Hp) 是一种单极、微需氧、多鞭毛、螺旋形的革兰氏阴性菌, 可在人胃黏膜上存活并定植。Hp作为与胃癌相关的Ⅰ类致癌物, 其对胃黏膜的长期刺激可导致萎缩性胃炎、消化性溃疡、胃癌和胃黏膜相关淋巴组织淋巴瘤等多种疾病。研究表明, Hp感染可诱导胃上皮细胞发生上皮-间质转化(epithelial-mesenchymal transition, EMT), 而EMT的异常调控则会导致胃癌发生。本文就Hp诱导胃上皮细胞发生EMT致胃癌的相关机制研究展开综述, 为胃癌的早期诊断和靶向治疗提供新思路。

Abstract: Helicobacter pylori (Hp) is a unipolar, microaerobic, multiflagellar, spiral-shaped Gram-negative bacterium that survives and colonizes human gastric mucosa. As a classⅠcarcinogen associated with gastric cancer, long-term stimulation of gastric mucosa by Hp can cause atrophic gastritis, peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. It has been reported that Hp can cause epithelial-mesenchymal transition (EMT) in gastric epithelial cells, thereby inducing gastric cancer. We review the mechanism of Hp-induced EMT in gastric epithelial cells, in order to provide new insights for early diagnosis and targeted therapy of gastric cancer.