Abstract: To address the challenges of the new era and promote the rational application of clinical epidemiology and evidence-based medicine methods in traditional Chinese medicine (TCM), Chinese Medicine Group, the Clinical Epidemiology and Evidence-based Medicine Association of Chinese Medical Association, gathered the related experts from all over the country and developed a consensus to improve the application of clinical epidemiology and evidence-based medicine methods in TCM. Delphi survey, consensus meetings and nominal groups were adopted in the process. This consensus summarizes the major challenges in the research of TCM and provides theoretical guidance for the development and application of clinical epidemiology and evidence-based medicine in TCM.