家族性地中海热的神经系统临床表现

董耀华, 宋红梅

董耀华, 宋红梅. 家族性地中海热的神经系统临床表现[J]. 协和医学杂志, 2023, 14(2): 334-338. DOI: 10.12290/xhyxzz.2022-0093
引用本文: 董耀华, 宋红梅. 家族性地中海热的神经系统临床表现[J]. 协和医学杂志, 2023, 14(2): 334-338. DOI: 10.12290/xhyxzz.2022-0093
DONG Yaohua, SONG Hongmei. Neurological Manifestations in Familial Mediterranean Fever[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 334-338. DOI: 10.12290/xhyxzz.2022-0093
Citation: DONG Yaohua, SONG Hongmei. Neurological Manifestations in Familial Mediterranean Fever[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 334-338. DOI: 10.12290/xhyxzz.2022-0093

家族性地中海热的神经系统临床表现

基金项目: 

国家重点研发计划 2021YFC2702001

北京市自然科学基金 L202050

详细信息
    通讯作者:

    宋红梅, E-mail:songhm1021@126.com

  • 中图分类号: R593;R596;R741

Neurological Manifestations in Familial Mediterranean Fever

Funds: 

National Key Research and Development Program of China 2021YFC2702001

Beijing Natural Science Foundation L202050

More Information
  • 摘要: 家族性地中海热(familial Mediterranean fever, FMF)是一种由MEFV基因突变导致的自身炎症性疾病, 主要临床表现为反复发作的发热和全身多处浆膜炎症, 部分FMF患者还可出现神经系统临床表现, 如癫痫、脱髓鞘疾病、无菌性脑膜炎等。由于FMF患者的神经系统表现较为罕见, 临床中易忽视其与基因突变的联系。本文针对FMF的重要神经系统表现及其与基因型的关系进行阐述, 以加深对FMF的认识, 为临床诊疗提供借鉴和参考。
    Abstract: Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations of the MEFV gene. The main clinical manifestations are recurrent fever and serous inflammation in various parts of the body. Some patients with FMF may also develop neurological manifestations such as epilepsy, demyelinating disease, aseptic meningitis. As neurological manifestations are rare in patients with FMF, the association between the two is often overlooked in clinical practice. In this paper, we reviewed the neurological manifestations of FMF and their relationship with genotypes, so as to deepen the understanding of the clinical manifestations of FMF and provide help for the diagnosis and treatment of patients with neurological manifestations.
  • 作者贡献:董耀华负责查阅文献资料、撰写论文;宋红梅负责指导论文撰写、提出修改意见。
    利益冲突:所有作者均声明不存在利益冲突
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出版历程
  • 收稿日期:  2022-02-28
  • 录用日期:  2022-03-20
  • 网络出版日期:  2022-10-05
  • 刊出日期:  2023-03-29

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