Abstract: Diabetes is one of the most common metabolic conditions worldwide. Regional anesthesia has benefits in promoting the restoration of function and may avoid worse outcomes compared to general anesthesia and intravertebral anesthesia. However, patients with diabetes are susceptible to peripheral neuropathy. The incidence of complications of regional anesthesia in patients with diabetes is supposed to be higher. The aim of this review is to explore the strategies of regional anesthesia implementation, the selection of adjuvant, and the way to reduce the risk of complications. This, in turn, will allow practitioners to undertake more informed decision-making and potentially modify their anesthetic technique for patients with diabetes.