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2019年期刊公开发表的中国临床实践指南文献调查与评价——资助与利益冲突

Investigation and Evaluation of Chinese Clinical Practice Guidelines Published in Medical Journals in 2019:Funding and Conflicts of Interest

    摘要
  • 摘要:
      目的  调查2019年期刊公开发表的中国临床实践指南中资助与利益冲突报告情况，为我国指南的资助与利益冲突规范化管理提供参考。
      方法  系统检索并筛选2019年期刊公开发表的中国临床实践指南，对资助与利益冲突相关信息进行提取、统计和分析。
      结果  共纳入指南226篇，其中报告资助和利益冲突的指南分别为68篇(30.1%)和120篇(53.1%)，二者同时报告的指南仅41篇(18.1%)；接受资助的指南涉及170项资金，主要为国家级(82项，48.2%)和省部级(52项，30.6%)基金项目；仅5篇(2.2%)指南报告了资金支持在指南制订过程中的用途。报告利益冲突的指南为120篇，其中102篇(85.0%)仅描述为“无利益冲突”，报告利益冲突收集、评估和管理方法的指南不足10%，且无获取相关信息的公开途径。
      结论  2019年期刊公开发表的中国临床实践指南资助与利益冲突报告率较低，报告内容不充分，相关文件无法公开获取。未来我国指南制订者应加强对资助和利益冲突领域的声明与管理。同时，管理者和研究者应积极完善相关政策，研发相应的报告规范。

     

    Abstract:
      Objective  To analyze the situation of funding and conflicts of interest of Chinese clinical practice guidelines published in medical journals in 2019, so as to provide reference for the standardized management of funding and conflicts of interest in Chinese guidelines.
      Methods  We systematically searched four electronic databases and additional sources for Chinese guidelines published in medical journals from January 1 to December 31, 2019. After screening, two researchers independently extracted data on funding and conflicts of interest and cross checked. We analyzed data by using EndNote X9, Microsoft Excel 2019 and SPSS 25.0 software.
      Results  We finally included 226 guidelines, of which, 187 were published in Chinese and 39 in English. There were 68 (30.1%) and 120 (53.1%) guidelines that reported funding and conflicts of interest, respectively, and only 41 (18.1%) that reported on both. There were 64 (28.3%) guidelines reported to have received funding, involving 170 projects, which were mainly at the national level (82, 48.2%) and ministerial and provincial-level (52, 30.6%). Only 5 (2.2%) guidelines reported the role of the funder in the stages of the development process. Among the 120 guidelines that reported conflicts of interest, 102 (85.0%) simply described "no conflicts of interest", while there were less than 10% of guidelines that reported the methods of collection, assessment and management for conflicts of interest, and there was no public access available to such information.
      Conclusions  There is a lack of effective management of funding and conflicts of interest in the Chinese guidelines published in medical journals in 2019, which is reflected in the low reporting rate, insufficient reporting contents and unavailable materials provided by the guideline developers. We suggest that guideline developers in the future should pay more attention to the field of guideline funding and conflicts of interest. Guidelines managers and researchers should actively improve management policies, and develop relevant reporting standards.

     

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