Abstract: With the increasing awareness of women about menopause, an increasing number of women are taking menopausal hormone therapy(MHT) to relieve relevant symptoms (such as irregular bleeding, hot flashes, sweating, sleep disorder, etc.), genitourinary tract atrophy, and osteoporosis. But the risk of breast cancer has always been one of the major concerns for women using MHT. The main safety issue in MHT is breast cancer. The conflict between MHT and the risk of breast cancer has been a hot topic in the field of gynecological endocrinology. This article aims to tell us how to rationally view the relationship between the two based on evidence-based medicine.