Abstract: Renal cell carcinoma(RCC) is a type of tumor with a high degree of malignancy in the urological system, often with distal metastases, especially to the central nervous system. These patients are often endowed with poorer prognosis and more complex management that require a multidisciplinary team(MDT). This article reported a case of clear cell renal cell carcinoma with multisystem metastases.The MDT of Peking Union Medical College Hospital(PUMCH) discussed and formulated the optimal individualized treatment scheme for the patient, and achieved good results after 5 consultations. Through a detailed analysis of discussions and decisions of MDT, the advantages in the treatment of such difficult and serious cases are demonstrated, including shortening the time window of treatment, breaking down departmental boundaries, improving patients' compliance, developing treatment recommendations in line with the concept of evidence-based medicine, and providing more accurate and individualized clinical managements for patients.