Abstract: This patient had recurrent hypoglycemia and frequent disturbance of consciousness caused by the insulinoma, but the definite location of the tumor could not be determined due to the limitations of conventional imaging, and he was unable to undergo surgical treatment because of his advanced age and chronic kidney disease. After multidisciplinary discussion, we applied cutting-edge imaging examination and emerging endoscopic treatment techniques, and finally solved the problem of diagnosis and treatment of the patient. This process reflects the importance of multidisciplinary cooperation: various disciplines explore the latest technologies and progress in the fields, and jointly assist in the management of complex diseases.