Abstract: Gastric cancer is one of the most common malignant neoplasms with high morbidity and mortality. Pyruvate kinase M2 (PKM2) is one of the key rate-limiting enzymes in glycolysis. The expression of PKM2 is significantly increased in a variety of tumors. It is currently considered that PKM2 is related to the development of tumors. PKM2 may promote the development of gastric cancer through the regulation of glycolysis, activation of PI3K/Akt/mTOR and inhibition of apoptosis of tumor cells. Literature will be briefly summarized in this review.