Volume 1 Issue 1
Jul.  2010
Turn off MathJax
Article Contents
Shan-shan YOU, Yu-xin JIANG, He LIU, Qing-li ZHU, Jing ZHANG, Qing DAI, Qiang SUN, Meng-su XIAO. Ultrasound Diagnosis of Phyllodes Tumors[J]. Medical Journal of Peking Union Medical College Hospital, 2010, 1(1): 66-71.
Citation: Shan-shan YOU, Yu-xin JIANG, He LIU, Qing-li ZHU, Jing ZHANG, Qing DAI, Qiang SUN, Meng-su XIAO. Ultrasound Diagnosis of Phyllodes Tumors[J]. Medical Journal of Peking Union Medical College Hospital, 2010, 1(1): 66-71.

Ultrasound Diagnosis of Phyllodes Tumors

More Information
  • Corresponding author: JIANG Yu-xin Tel; 010-65295491, E-mail:yuxinjiangxh@yahoo.com.cn
  • Received Date: 2010-04-12
  • Publish Date: 2010-07-30
  •   Objective  To investigate the value of color Doppler sonography in the diagnosis of phyllodes tumors with different pathologic types and in the differential diagnosis of phyllodes tumor and fibroadenoma.  Methods  The sonographic characteristics of 87 breast phyllodes tumors confirmed by histopathology from Janurary 2005 to December 2009 were retrospectively studied. In addition, 120 breast fibroadenoma confirmed by histopathology between June 2008 and August 2008 were set as the control group. The pathologic results were regarded as the gold standard.  Results  The patients with phyllodes tumors were older than the patients with fibroadenoma[(39.86±9.68) years vs. (34.23±12.33) years; P < 0.05]. The diameter of phyllodes tumor was larger than that of fibroadenoma[(3.70±2.26) cm vs. (1.92±1.13) cm; P < 0.05]. As shown by color Doppler sonography, the shape of the tumor, retrotumor acoustic phenomenon, and cystic area were significantly different between phyllodes tumor and fibroadenoma (P < 0.05). The tumor size and Color Doppler flow grade were independent risk factors of phyllodes tumors (OR=1.36 and 1.82, respectively; both P < 0.05). Benign, borderline, and malignant phyllodes tumors displayed no significantly different sonographic findings.  Conclusions  There is a substantial overlap in the sonographic characteristics between phyllodes tumors and fibroadenoma. If lobulation, posterior acoustic shadowing, and cystic area are observed under color Doppler sonography, a diagnosis of phyllodes tumor can be considered. Sonography can not distinguish benign, borderline, or malignant phyllodes tumors.
  • loading
  • [1] Palmer ML, De Risi DC, Pelikan A, et al. Treatment options and recurence potential for cystosarcoma phyllodes [J]. Surg Gynecol Obstet, 1990, 170:193-196.. http://ci.nii.ac.jp/naid/10008524763
    [2] Rowell MD, Perry RR, Hsiu JG, et al. Phyllodes tumors [J]. AmJ Surg, 1993, 165:376-379. doi:  10.1016/S0002-9610(05)80849-9
    [3] Rosen PP, Oberman HA. Cystosarcoma phyllodes[M] // Rosai J, Sobin LH. Atlas of tumor pathology: tumors of the mammary gland, fasc7, ser3. W ashington, DC: Armed Forces Institute of Pathology, 1993: 107-114.
    [4] Belkacemi Y, Bousquet G, Marsiglia H, et al. Phyllodes tumor of the breast[J]. Int J Radiat Oncol Biol Phys, 2008, 70:492-500. doi:  10.1016/j.ijrobp.2007.06.059
    [5] Lee AHS. Recent developments in the histological diagnosis of spindle cell carcinoma, fibromatosis and phyllodes tumour of the breast[J]. Histopathology, 2008, 52:45-57. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=10.1111/j.1365-2559.2007.02893.x
    [6] Barrio AV, Clark BD, Goldberg JI, et al. Clinicopathologic features and long-term outcomes of 293 phyllodes tumors of the breast[J]. Ann Surg Oncol, 2007, 14:2961 -2970. doi:  10.1245/s10434-007-9439-z
    [7] Taira N, Takabatake D, Aogi K, et al. Phyllodese tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin[J]. Jpn J Clin Oncol, 2007, 37:730-736. doi:  10.1093/jjco/hym099
    [8] Adler DD, Carson PL, Rubin JM, et al. Doppler ulrasound color flow imaging in the study of breast cancer: preliminary findings[J]. Ultrasound Med Biol, 1990, 16:553-559. doi:  10.1016/0301-5629(90)90020-D
    [9] Azzopardi JG. Sarcoma in the breast[M] //Benningron J. Problems in breast pathology. Vol. Ⅱ. Philadelphia: WB Saunders, 1979: 355-359.
    [10] Salvadori B, Cusumano F, Del-Ro R, et al. Surgical treatment of phyllodes tumors of the breast[J]. Cancer, 1989, 63:2532-2536. doi:  10.1002/1097-0142(19890615)63:12<2532::AID-CNCR2820631229>3.0.CO;2-Q
    [11] Miller J. Uber den feineren Ban und Die Formen der Krankaften Geschwulste 1[M]. Berlin: G Reiner, 1838: 54-57.
    [12] Wurdinger s, Herog AB, Fischer DR, et al. Diferentiation of phyllodes breast tumors from fibroadenomas on MRI[J]. AJR Am J Roentgenol, 2005, 185:1317-1321. doi:  10.2214/AJR.04.1620
    [13] Bernstein L, Deapen D, Ross RK. The descriptive epidemiology of malignant cystosarcoma phyllodes tumors of the breast[J]. Cancer, 1993, 71: 3020-3024. doi:  10.1002/1097-0142(19930515)71:10<3020::AID-CNCR2820711022>3.0.CO;2-G
    [14] Reinfuss M, Mitus J, Duda K, et al. The treatment and prognosis of patients with phyllodes tumor of the breast[J]. Cancer, 1996, 77:910-916. doi:  10.1002/(SICI)1097-0142(19960301)77:5<910::AID-CNCR16>3.0.CO;2-6
    [15] Chua CL, Thomas A, Ng BK. Cystosarcoma phyllodes: a review of surgical options[J]. Surgery, 1989, 105:141147. http://europepmc.org/abstract/MED/2536964
    [16] Chao TC, Lo YF, Chen SC, et al. Sonographie features of phyllodes tumors of the breast[J]. Utrasound Obstet Gynecol, 2002, 20:64-71. doi:  10.1046/j.1469-0705.2002.00736.x
    [17] 包凌云, 刘小明, 许亮, 等.超声对乳腺叶状肿瘤与纤维腺瘤的鉴别诊断价值[J].医学影像学杂志, 2009, 19:777-779. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=yxyxxzz200906043
    [18] Liberman L, Bonaccio E, Hamele-Bena D, et al. Benign and malignant phyllodes tumors: mammographie and sonographic findings[J]. Radiology, 1996, 198:121-124. doi:  10.1148/radiology.198.1.8539362
    [19] Buchberger W, Strasser K, Heim K, et al. Phylloides tumor: findings on mammography, sonography, and aspiration cytology in 10 cases[J]. AJR Am J Roentgenol, 1991, 157:715-719. doi:  10.2214/ajr.157.4.1654022
    [20] Yilmaz E, Sal s, Lebe B. Dffrentation of phyllodes tumors versus fibroadenomas[J]. Acta Radiol, 2002, 43: 34 -39. http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=6644213&site=ehost-live
    [21] Dyer NH, Bridger JE, Taylor RS. Cystosarcoma phylloides [J]. BrJ Surg, 1966, 53:450-455. doi:  10.1002/bjs.1800530517
    [22] 严松莉, 唐旭平, 曹亚丽.超声在乳腺叶状肿瘤和纤维腺瘤鉴别诊断中的价值[J].中华超声影像学杂志, 2006, 15:202-204. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zhcsyx200603012
  • 加载中


    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(3)  / Tables(3)

    Article Metrics

    Article views (297) PDF downloads(20) Cited by()
    Proportional views


    DownLoad:  Full-Size Img  PowerPoint