Yi-bing ZHU, Wei LI. How Do Clinicians Understand Meta-analysis[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(3): 314-319. DOI: 10.3969/j.issn.1674-9081.20200073
Citation: Yi-bing ZHU, Wei LI. How Do Clinicians Understand Meta-analysis[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(3): 314-319. DOI: 10.3969/j.issn.1674-9081.20200073

How Do Clinicians Understand Meta-analysis

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  • Corresponding author:

    LI Wei Tel: 86-10-60866199, E-mail: liwei@mrbc-nccd.com

  • Received Date: March 11, 2020
  • Issue Publish Date: May 29, 2020
  • Meta-analysis is an important method of systematic review. With the development of evidence-based medicine, there are more and more meta-analysis published. Reading and interpreting meta-analysis becomes one of the important methods for obtaining cutting-edge information. Mastering meta-analysis is essential for physicians in clinical work and research. We explained the forest plot, chart of bias evaluation, and funnel plot in detail through examples in this article. Moreover, we introduced the evaluation method of heterogeneity, robustness, and sample size to assess whether the results of the meta-analysis are reliable and can be applied to the clinical practice, in order to help physicians to correctly grasp the interpretation methods of meta-analysis.
  • [1]
    彭晓霞.Meta-分析的方法学局限性及其适用领域[J].协和医学杂志,2017,6:381-386. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xhyx201706013
    [2]
    Smith ML,Glass GV.Meta-analysis of psychotherapy outcome studies[J].Am Psychol,1977,32:752-760. DOI: 10.1037/0003-066X.32.9.752
    [3]
    Moher D,Liberati A,Tetzlaff J,et al.Preferred reporting items for systematic reviews and Meta-analyses:the PRISMA statement[J].BMJ,2009,339:b2535. DOI: 10.1136/bmj.b2535
    [4]
    Ioannidis JP.The mass production of redundant,mislead-ing,and conflicted systematic reviews and Meta-analyses[J].Milbank Q,2016,94:485-514. DOI: 10.1111/1468-0009.12210
    [5]
    Vetter TR.Systematic Review and Meta-analysis:Some-times Bigger Is Indeed Bette[J].Anesth Analg,2019,128:575-583. DOI: 10.1213/ANE.0000000000004014
    [6]
    Zhu Y,Huang H,Xi X,et al.Terlipressin for septic shock patients:a Meta-analysis of randomized controlled study[J].J Intensive Care,2019,7:16. DOI: 10.1186/s40560-019-0369-1
    [7]
    Higgins JPT,Green S.Cochrane Handbook for systematic reviews of interventions version 5.1.0[M/OL].The Cochrane Collaboration.2011.https://training.cochrane.org/handbook.
    [8]
    Huang HB,Xu B,Liu GY,et al.Use of noninvasive ventilation in immunocompromised patients with acute respira-tory failure:a systematic review and Meta-analysis[J].Crit Care,2017,21:4. DOI: 10.1186/s13054-016-1586-9
    [9]
    Wang M,Williamson JM.Generalization of the Mantel-Haenszel estimating function for sparse clustered binary data[J].Biometrics,2005,61:973-981. DOI: 10.1111/j.1541-0420.2005.00362.x
    [10]
    张天嵩,钟文昭,李博.实用循证医学方法学[M].湖南:中南大学出版社,2014.
    [11]
    Olivo SA,Macedo LG,Gadotti IC,et al.Scales to assess the quality of randomized controlled trials:a systematic review[J].Phys Ther,2008,88:156-175. DOI: 10.2522/ptj.20070147
    [12]
    Huang HB,Jiang W,Wang CY,et al.Stress ulcer prophylaxis in intensive care unit patients receiving enteral nutrition:a systematic review and Meta-analysis[J].Crit Care,2018,22:20. DOI: 10.1186/s13054-017-1937-1
    [13]
    Zhang ZH,Xu X,Ni HY.Small studies may overestimate the effect sizes in critical care Meta-analyses:a Meta-epidemiological study[J].Crit Care,2013,17:R2. DOI: 10.1186/cc11919
    [14]
    Wetterslev J,Thorlund K,Brok J,et al.Trial sequential analysis may establish when firm evidence is reached in cumulative Meta-analysis[J].J Clin Epidemiol,2008,61:64-75. DOI: 10.1016/j.jclinepi.2007.03.013
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