Email Alert RSS
Volume 11 Issue 3
May  2020
Turn off MathJax
Article Contents
Abstract
References
Related Articles
Yi-bing ZHU, Wei LI. How Do Clinicians Understand Meta-analysis[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(3): 314-319. DOI: 10.3969/j.issn.1674-9081.20200073
Citation: Yi-bing ZHU, Wei LI. How Do Clinicians Understand Meta-analysis[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(3): 314-319. DOI: 10.3969/j.issn.1674-9081.20200073
shu

How Do Clinicians Understand Meta-analysis

  • Medical Research and Biometrics Center, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Center of Cardiovascular Disease, Beijing 100037, China

More Information
  • Corresponding author:

    LI Wei Tel: 86-10-60866199, E-mail: liwei@mrbc-nccd.com

  • Received Date: March 11, 2020
  • Issue Publish Date: May 29, 2020
    Graphical Abstract
    • Abstract
  • Meta-analysis is an important method of systematic review. With the development of evidence-based medicine, there are more and more meta-analysis published. Reading and interpreting meta-analysis becomes one of the important methods for obtaining cutting-edge information. Mastering meta-analysis is essential for physicians in clinical work and research. We explained the forest plot, chart of bias evaluation, and funnel plot in detail through examples in this article. Moreover, we introduced the evaluation method of heterogeneity, robustness, and sample size to assess whether the results of the meta-analysis are reliable and can be applied to the clinical practice, in order to help physicians to correctly grasp the interpretation methods of meta-analysis.
    • FullText(HTML)
    • References (14)
  • [1]
    彭晓霞.Meta-分析的方法学局限性及其适用领域[J].协和医学杂志,2017,6:381-386. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xhyx201706013
    [2]
    Smith ML,Glass GV.Meta-analysis of psychotherapy outcome studies[J].Am Psychol,1977,32:752-760. DOI: 10.1037/0003-066X.32.9.752
    [3]
    Moher D,Liberati A,Tetzlaff J,et al.Preferred reporting items for systematic reviews and Meta-analyses:the PRISMA statement[J].BMJ,2009,339:b2535. DOI: 10.1136/bmj.b2535
    [4]
    Ioannidis JP.The mass production of redundant,mislead-ing,and conflicted systematic reviews and Meta-analyses[J].Milbank Q,2016,94:485-514. DOI: 10.1111/1468-0009.12210
    [5]
    Vetter TR.Systematic Review and Meta-analysis:Some-times Bigger Is Indeed Bette[J].Anesth Analg,2019,128:575-583. DOI: 10.1213/ANE.0000000000004014
    [6]
    Zhu Y,Huang H,Xi X,et al.Terlipressin for septic shock patients:a Meta-analysis of randomized controlled study[J].J Intensive Care,2019,7:16. DOI: 10.1186/s40560-019-0369-1
    [7]
    Higgins JPT,Green S.Cochrane Handbook for systematic reviews of interventions version 5.1.0[M/OL].The Cochrane Collaboration.2011.https://training.cochrane.org/handbook.
    [8]
    Huang HB,Xu B,Liu GY,et al.Use of noninvasive ventilation in immunocompromised patients with acute respira-tory failure:a systematic review and Meta-analysis[J].Crit Care,2017,21:4. DOI: 10.1186/s13054-016-1586-9
    [9]
    Wang M,Williamson JM.Generalization of the Mantel-Haenszel estimating function for sparse clustered binary data[J].Biometrics,2005,61:973-981. DOI: 10.1111/j.1541-0420.2005.00362.x
    [10]
    张天嵩,钟文昭,李博.实用循证医学方法学[M].湖南:中南大学出版社,2014.
    [11]
    Olivo SA,Macedo LG,Gadotti IC,et al.Scales to assess the quality of randomized controlled trials:a systematic review[J].Phys Ther,2008,88:156-175. DOI: 10.2522/ptj.20070147
    [12]
    Huang HB,Jiang W,Wang CY,et al.Stress ulcer prophylaxis in intensive care unit patients receiving enteral nutrition:a systematic review and Meta-analysis[J].Crit Care,2018,22:20. DOI: 10.1186/s13054-017-1937-1
    [13]
    Zhang ZH,Xu X,Ni HY.Small studies may overestimate the effect sizes in critical care Meta-analyses:a Meta-epidemiological study[J].Crit Care,2013,17:R2. DOI: 10.1186/cc11919
    [14]
    Wetterslev J,Thorlund K,Brok J,et al.Trial sequential analysis may establish when firm evidence is reached in cumulative Meta-analysis[J].J Clin Epidemiol,2008,61:64-75. DOI: 10.1016/j.jclinepi.2007.03.013
    • Related Articles

  • Related Articles

    [1]JIA Chunyu, WANG Gangan, WANG Jiahui, CHEN Gang, ZHENG Ke, LI Xuemei. Correlation Between Neutrophil to Lymphocyte Ratio and eGFR in Diabetic Patients: A Cross-sectional Analysis Based on NHANES Data[J]. Medical Journal of Peking Union Medical College Hospital, 2025, 16(2): 379-385. DOI: 10.12290/xhyxzz.2024-0908
    [2]LI Yanbing, ZHOU Menglan, XU Yingchun. Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms[J]. Medical Journal of Peking Union Medical College Hospital, 2025, 16(1): 177-183. DOI: 10.12290/xhyxzz.2024-0159
    [3]MA Xing, LIU Chang. Prognosis and Treatment Strategies of FIGO 2018 Stage ⅢC Cervical Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(6): 1253-1260. DOI: 10.12290/xhyxzz.2024-0097
    [4]LIU Yuan, ZHAO Lin. Update and Interpretation of 2022 National Comprehensive Cancer Network Clinical Practice Guidelines for Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 999-1004. DOI: 10.12290/xhyxzz.2022-0271
    [5]Yuan XIA, Xiang-pei LI. The Role of MicroRNA Regulation of Interferon-α in the Pathogenesis of Systemic Lupus Erythematosus[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(6): 673-678. DOI: 10.3969/j.issn.1674-9081.2019.06.021
    [6]Li Wang, Kailiang Cheng. Database of Electronic Health Records: Application in Clinical Research and Bias Control[J]. Medical Journal of Peking Union Medical College Hospital, 2018, 9(2): 177-182. DOI: 10.3969/j.issn.1674-9081.2018.02.014
    [7]Hao GUO, Wen-da WANG, Yi CAI, Yu-shi ZHANG. Progress in Research on MicroRNA in Tuberous Sclerosis Complex Related Diseases[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(4-5): 283-288. DOI: 10.3969/j.issn.1674-9081.2017.05.017
    [8]Lei LI, Hui-min BAI, Shi-fu WENG, Li-min YANG, Jin-guang WU, Yi-zhuang XU, Keng SHEN. Laboratory Study for Analysis of Intra-tumor Heterogeneity of Ovarian Cancer by Fourier Transform Infrared Spectroscopy[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(4-5): 268-273. DOI: 10.3969/j.issn.1674-9081.2017.05.014
    [10]Jie SHI, Zhi-yong LIANG, Tong-hua LIU. Expression of Cyclin D1 in Invasive Lobular Carcinoma of the Breast and Its Significance[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(1): 8-12. DOI: 10.3969/j.issn.1674-9081.2012.01.004

  • Cited by

    Periodical cited type(13)

    1. 朱成占，张高伟，张勇. 经肛门内镜微创手术治疗直肠癌前病变的应用效果研究. 首都食品与医药. 2019(23): 29 .
    2. 封益飞，王诗佳，张悦，吉冰，钱文伟，季东健，张冬生，胥子玮，王勇，傅赞，孙跃明. 经肛门内镜微创手术治疗直肠占位的临床体会(附53例报告). 腹腔镜外科杂志. 2017(10): 753-756 .
    3. 刘斌，孙壮，杜继明，宫爱民. 20例直肠肿瘤经肛门内镜下手术治疗体会. 中国医疗器械信息. 2017(10): 67-68 .
    4. 林国乐，邱辉忠，周皎琳，牛备战，孙曦羽，陆君阳，张冠南. 经肛门内镜微创手术治疗直肠肿瘤的临床研究. 中国全科医学. 2016(03): 254-259 .
    5. 苏航，王竟，芦婷婷，鲁大鹏. 吻合器经肛门行直肠黏膜选择性切除钉合术治疗低位直肠良性肿瘤疗效分析. 大连医科大学学报. 2015(04): 355-357 .
    6. 张小虎，李志霞，安大立，刘靖，李伟. TEM治疗直肠肿瘤19例体会. 中华结直肠疾病电子杂志. 2015(05): 68-71 .
    7. 林国乐，邱辉忠，周皎琳，牛备战，孙曦羽，陆君阳，张冠南. 经肛门内镜微创手术的适应证与并发症. 中华结直肠疾病电子杂志. 2015(05): 63-67 .
    8. 彭华敏. 经肛门内镜微创手术(TEM)治疗29例直肠肿瘤的临床疗效观察. 现代诊断与治疗. 2014(06): 1377-1378 .
    9. 孙小林，杨龙江，娄善华. 经肛门内镜显微手术的临床分析. 中国药物经济学. 2014(S2): 428-430 .
    10. 黄兴，黄忠诚，刘祺. 低位直肠癌的治疗及术后评估. 中国现代普通外科进展. 2012(05): 385-388 .
    11. 曾庆智. 直肠癌外科手术治疗研究进展. 右江民族医学院学报. 2012(06): 793-795 .
    12. 陈镇武. 老年人低位直肠癌前切除术后回肠置管造口与横结肠造口的对比研究. 吉林医学. 2011(16): 3199-3200 .
    13. 刘宝华. 直肠癌局部切除术的国内外进展. 中国普外基础与临床杂志. 2011(11): 1132-1134 .

    Other cited types(8)

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (964) PDF downloads (371) Cited by(21)
    Related
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

      Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

      /

      DownLoad:  Full-Size Img  PowerPoint
      Return
      Return
      x Close Forever Close