Consensus and Controversy on the Treatment of Multiple Endocrine Neoplasia

Multiple endocrine neoplasia (MEN) is an autosomal dominant hereditary disease involving multiple endocrine glands with two or more endocrine tumors occurring simultaneously or successively. MEN-related tumors include primary hyperparathyroidism, pheochromocytoma, medullary thyroid cancer, pancreatic neuroendocrine neoplasia, and pituitary adenoma, etc. Although the clinical characteristics and treatment of these tumors are similar to those of sporadic tumors, there are differences in some aspects. In recent years, there has been some consensus achieved on the treatment of MEN-related tumors. But there are also some controversies. The timing and scope of surgical resection are the focus of controversies.