Correlation of Proton Pump Inhibitors and Gastric Carcinoma with Fundic Gland Polyps

Fundic gland polyps are single or multiple wide-based polypoid protruding lesions formed by the mucous membrane of stomach fundus and body, which are common at home and abroad. They were initially described in patients with familial adenomatous polyposis and are now increasingly reported to be associated with long-term use of proton pump inhibitors. However, no definite conclusion has been drawn on the relationship between them. There are few studies on the incidence and development of fundic gland polyps in patients receiving long-term proton pump inhibitors in China. Whether there is a correlation between the two is still controversial, and whether fundic gland polyps are related to gastric carcinoma is not clear. This paper will review the relationship between fundic gland polyps and proton pump inhibitors and its correlation with gastric carcinoma, in order to provide evidence for the management strategy of fundic gland polyps and promote the standard application of proton pump inhibitors in clinical practice.