Zi WANG, Bing-bin ZHAO, Jiu-liang ZHAO, Hua CHEN, Guo-tao MA, Jian-zhou LIU, Wen-qian CHEN, Chi SHAO, Jin-zhi LAI, Wei CHENG, Qi MIAO, Xiao-feng ZENG, Feng-chun ZHANG, Jin-jing LIU. Arthritis, Dyspnea and Hemoptysis on Exertion[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(3): 347-353. DOI: 10.3969/j.issn.1674-9081.20190181
Citation: Zi WANG, Bing-bin ZHAO, Jiu-liang ZHAO, Hua CHEN, Guo-tao MA, Jian-zhou LIU, Wen-qian CHEN, Chi SHAO, Jin-zhi LAI, Wei CHENG, Qi MIAO, Xiao-feng ZENG, Feng-chun ZHANG, Jin-jing LIU. Arthritis, Dyspnea and Hemoptysis on Exertion[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(3): 347-353. DOI: 10.3969/j.issn.1674-9081.20190181

Arthritis, Dyspnea and Hemoptysis on Exertion

More Information
  • Corresponding author:

    LIU Jin-jing Tel: 86-10-69155004,E-mail:wingsforjane@163.com

  • Received Date: August 21, 2019
  • Issue Publish Date: May 29, 2020
  • Intracardiac thrombus is a rare complication of Antiphospholipid syndrome secondary to systemic lupus erythematosus (SLE). Its treatment is extremely tough and requires a multidisciplinary approach. We reported a case of SLE with intracardiac thrombus and pulmonary embolism. The patient was complicated with hemoptysis and kidney injury, and had a high risk of sudden death from incidental thrombus shedding off. In the state of thrombosis and hemorrhage, the management of anticoagulation and the evaluation and treatment of the primary disease complicated with infection are challenging. The multidisciplinary collaboration helpedus to create a more favorable surgical condition while controlling SLE aggressively. After surgical treatment at the proper time, the outcome of the patient was satisfying.
  • [1]
    徐希奇,荆志成. 第六届世界肺高血压会议:聚焦肺高血压定义与诊断分类更新[J]. 协和医学杂志,2018,9:197-201.
    [2]
    Cervera R, Serrano R, Pons-Estel GJ, et al. Morbidity and mortality in the antiphospholipid syndrome during a 10-year period:a multicentre prospective study of 1000 patients[J]. Ann Rheum Dis, 2015, 74:1011-1018. https://pubmed.ncbi.nlm.nih.gov/24464962/
    [3]
    Vnlü O, Zuily S, Erkan D. The clinical significance of antiphospholipid antibodies in systemic lupus erythematosus[J]. Eur J Rheumatol, 2016, 3:75-84. DOI: 10.5152/eurjrheum.2015.0085
    [4]
    Chung WS, Lin CL, Chang SN, et al. Systemic lupus erythematosus increases the risks of deep vein thrombosis and pulmonary embolism:a nationwide cohort study[J]. J Thromb Haemost, 2014, 12:452-458. DOI: 10.1111/jth.12518
    [5]
    Tektonidou MG, Andreoli L, Limper M, et al. EULAR recommendations for the management of antiphospholipid syndrome in adults[J]. Ann Rheum Dis, 2019, 78:1296-1304. DOI: 10.1136/annrheumdis-2019-215213
    [6]
    Kanakis MA, Kapsimali V, Vaiopoulos AG, et al. The lung in the spectrum of antiphospholipid syndrome[J]. Clin Exp Rheumatol, 2013, 31:452-457.
    [7]
    Prashanth P, Mukhaini MK. Primary antiphospholipid syndrome with recurrent coronary thrombosis, acute pulmonary thromboembolism and intracerebral hematoma[J]. J Invasive Cardiol, 2009, 21:E254-E258. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=Open J-Gate000001859680
    [8]
    Zifman E, Rotman-Pikielny P, Berlin T, et al. Insertion of inferior vena cava filters in patients with the antiphospholipid syndrome[J]. Semin Arthritis Rheum, 2009, 38:472-477. DOI: 10.1016/j.semarthrit.2008.01.016
    [9]
    Kaplan SD, Chartash EK, Pizzarello RA, et al. Cardiac manifestations of the antiphospholipid syndrome[J]. Am Heart J, 1992, 124:1331-1338. DOI: 10.1016/0002-8703(92)90420-Z
    [10]
    Dhibar DP, Sahu KK, Varma SC, et al. Intra-cardiac thrombus in antiphospholipid antibody syndrome:An unusual cause of fever of unknown origin with review of literature[J]. J Cardiol Cases, 2016, 14:153-156. DOI: 10.1016/j.jccase.2016.07.005
    [11]
    Cianciulli TF, Saccheri MC, Redruello HJ, et al. Right atrial thrombus mimicking myxoma with pulmonary embolism in a patient with systemic lupus erythematosus and secondary antiphospholipid syndrome[J]. Tex Heart Inst J, 2008, 35:454-457. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607098/
    [12]
    Khalid U, Hirudayaraj P, Lakkis N, et al. Left atrial thrombus mimicking a myxoma in a patient with systemic lupus erythematosus[J]. Hellenic J Cardiol, 2014, 55:167-170. https://www.ncbi.nlm.nih.gov/pubmed/24681796
    [13]
    Willens HJ, Lowery MH, Lopez E, et al. Rapid resolution of left ventricular thrombus in antiphospholipid syndrome[J]. Echocardiography, 2003, 20:67-70. DOI: 10.1046/j.1540-8175.2003.00009.x
    [14]
    Zahid H, Hassan S, Gul S, et al. Co-existing Bilateral Pulmonary Embolism and Intra-cardiac Mass:A Case of Catastrophic Antiphospholipid Syndrome-like Disease[J]. Cureus, 2018, 10:e3438.
    [15]
    Tektonidou MG, Andreoli L, Limper M, et al. EULAR recommendations for the management of antiphospholipid syndrome in adults[J]. Ann Rheum Dis, 2019,78:1296-1304. DOI: 10.1136/annrheumdis-2019-215213
    [16]
    Tselios K, Gladman DD, Urowitz MB. Systemic lupus erythematosus and pulmonary arterial hypertension:links, risks, and management strategies[J]. Open Access Rheumatol, 2016, 9:1-9. DOI: 10.2147/OARRR.S123549
    [17]
    Lai YC, Potoka KC, Champion HC, et al. Pulmonary arterial hypertension:the clinical syndrome[J]. Circ Res, 2014, 115:115-130. DOI: 10.1161/CIRCRESAHA.115.301146
    [18]
    Hemnes AR, Kiely DG, Cockrill BA, et al. Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute[J]. Pulm Circ, 2015, 5:435-465. DOI: 10.1086/682230
    [19]
    Tanaka E, Harigai M, Tanaka M, et al. Pulmonary hypertension in systemic lupus erythematosus:evaluation of clinical characteristics and response to immunosuppressive treatment[J]. J Rheumatol, 2002, 29:282-287. https://www.jrheum.org/content/29/2/282
    [20]
    Gonzalez-Lopez L, Cardona-Muñoz EG, Celis A, et al. Therapy with intermittent pulse cyclophosphamide for pulmonary hypertension associated with systemic lupus erythemato-sus[J]. Lupus, 2004, 13:105-112. DOI: 10.1191/0961203304lu509oa
    [21]
    Sanchez O, Sitbon O, Jaïs X, et al. Immunosuppressive therapy in connective tissue diseases-associated pulmonary arterial hypertension[J]. Chest, 2006, 130:182-189. DOI: 10.1378/chest.130.1.182
  • Cited by

    Periodical cited type(3)

    1. 杨文君,何红晖,金萍. 临床思维训练在内分泌科住院医师规范化培训中的实践. 中国中医药现代远程教育. 2022(17): 175-176 .
    2. 朱凌云,李晓军,朱余蓉,马天水,崔丽娟,种琨瑛,尹亮. 案例教学法在内分泌临床诊疗思维培养中的探讨. 农垦医学. 2021(01): 90-92 .
    3. 王婉秋,郭新红,李军. 内分泌代谢科门诊教学在住院医师规范化培训带教中的应用. 农垦医学. 2021(05): 468-470 .

    Other cited types(0)

Catalog

    Article Metrics

    Article views (535) PDF downloads (80) Cited by(3)
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return
    x Close Forever Close