Fang JIANG, Yang XIANG. Deeper Understanding of Epithelioid Trophoblastic Tumor[J]. Medical Journal of Peking Union Medical College Hospital, 2018, 9(1): 31-35. doi: 10.3969/j.issn.1674-9081.2018.01.007
Citation: Fang JIANG, Yang XIANG. Deeper Understanding of Epithelioid Trophoblastic Tumor[J]. Medical Journal of Peking Union Medical College Hospital, 2018, 9(1): 31-35. doi: 10.3969/j.issn.1674-9081.2018.01.007

Deeper Understanding of Epithelioid Trophoblastic Tumor

doi: 10.3969/j.issn.1674-9081.2018.01.007
More Information
  • Corresponding author: XIANG Yang Tel:010-69155635, E-mail:xiangy@pumch.cn
  • Received Date: 2017-05-10
  • Publish Date: 2018-01-30
  • Epithelioid trophoblastic tumor(ETT) is a rare type of gestational trophoblastic neoplasm(GTN), which originates from intermediate trophoblastic cells of chorionic-type. Its presentation is complex and diverse, making the diagnosis challenging. The diagnosis depends mainly on pathological diagnosis. Generally, ETT is a slow-growing malignant tumor, though some cases may have aggressive and fatal clinical courses involving multiple metastases, and demonstrate a greater malignant behavior compared to the placental site trophoblastic tumor(PSTT). Surgical resection remains the cornerstone of treatment. There is no standardized postoperative adjuvant chemotherapy regimen. Multifocal disease within the uterus, the presence of extra-uterine disease, an interval greater than 4 years from antecedent pregnancy, and high Ki-67 index may be markers of poor prognosis. At present, the behavior and clinical course of ETT are yet not fully understood. More cases and data of ETT should be collected to help guide diagnosis and management.
  • loading
  • [1] Kim JH, Lee SK, Hwang SH, et al. Extrauterine epithelioid trophoblastic tumor in hysterectomized woman[J]. Obstet Gynecol Sci, 2017, 60:124-128. doi:  10.5468/ogs.2017.60.1.124
    [2] Mazur MT, Lurain JR, Brewer JI. Fatal gestational choriocarcinoma. Clinicopathologic study of patients treated at a trophoblastic disease center[J]. Cancer, 1982, 50:1833-1846. doi:  10.1002/1097-0142(19821101)50:9<1833::AID-CNCR2820500930>3.0.CO;2-4
    [3] Hamazaki S, Nakamoto S, Okino T, et al. Epithelioid trophoblastic tumor:morphological and immunohistochemical study of three lung lesions[J]. Hum Pathol, 1999, 30:1321-1327. doi:  10.1016/S0046-8177(99)90063-1
    [4] Shih IM, Kurman RJ. Epithelioid trophoblastic tumor:a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma[J]. Am J Surg Pathol, 1998, 22:1393-1403. doi:  10.1097/00000478-199811000-00010
    [5] Park JW, Bae JW. Epithelioid trophoblastic tumor in a postmenopausal woman:a case report[J]. J Menopausal Med, 2016, 22:50-53. doi:  10.6118/jmm.2016.22.1.50
    [6] Zhang X, Shi H, Chen X. Epithelioid trophoblastic tumor after induced abortion with previous broad choriocarcinoma:a case report and review of literature[J]. Int J Clin Exp Pathol, 2014, 7:8245-8250. http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_PM25550880
    [7] Davis MR, Howitt BE, Quade BJ, et al. Epithelioid trophoblastic tumor:a single institution case series at the New England Trophoblastic Disease Center[J]. Gynecol Oncol, 2015, 137:456-461. doi:  10.1016/j.ygyno.2015.03.006
    [8] Jordan S, Randall LM, Karamurzin Y, et al. Differentiating squamous cell carcinoma of the cervix and epithelioid trophoblastic tumor[J]. Int J Gynecol Cancer, 2011, 21:918-922. doi:  10.1097/IGC.0b013e31821a278d
    [9] Keser SH, Kokten SC, Cakir C, et al. Epithelioid trophoblastic tumor[J]. Taiwan J Obstet Gynecol, 2015, 54:621-624. doi:  10.1016/j.tjog.2015.08.020
    [10] Okumura M, Fushida K, Rezende WW, et al. Sonographic appearance of gestational trophoblastic disease evolving into epithelioid trophoblastic tumor[J]. Ultrasound Obstet Gynecol, 2010, 36:249-251. https://www.ncbi.nlm.nih.gov/pubmed/20069561
    [11] Kageyama S, Kanoto M, Sugai Y, et al. MR imaging of uterine epithelioid trophoblastic tumor:a case report[J]. Magn Reson Med Sci, 2016, 15:411-415. doi:  10.2463/mrms.cr.2015-0070
    [12] Shih IM, Kurman RJ. p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations[J]. Am J Surg Pathol, 2004, 28:1177-1183. doi:  10.1097/01.pas.0000130325.66448.a1
    [13] Mao TL, Seidman JD, Kurman RJ, et al. Cyclin E and p16 immunoreactivity in epithelioid trophoblastic tumor-an aid in differential diagnosis[J]. Am J Surg Pathol, 2006, 30:1105-1110. https://www.ncbi.nlm.nih.gov/pubmed/16931955
    [14] Seckl MJ, Sebire NJ, Fisher RA, et al. Gestational trophoblastic disease:ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up[J]. Ann Oncol, 2013, 24:39-50. doi:  10.1093/annonc/mdt345
    [15] Zhang X, Zhou C, Yu M, et al. Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy:report of a case and review of literature[J]. Int J Clin Exp Pathol, 2015, 8:7254-7259. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525957/
    [16] Lu B, Zhang X, Liang Y. Clinicopathologic analysis of postchemotherapy gestational trophoblastic neoplasia:an entity overlapping with epithelioid trophoblastic tumor[J]. Int J Gynecol Pathol, 2016, 35:516-524. doi:  10.1097/PGP.0000000000000259
    [17] Ngan HY, Seckl MJ, Berkowitz RS, et al. Update on the diagnosis and management of gestational trophoblastic disease[J]. Int J Gynaecol Obstet, 2015, 131:S123-S126. doi:  10.1016/j.ijgo.2015.06.008
    [18] Palmer JE, Macdonald M, Wells M, et al. Epithelioid trophoblastic tumor:a review of the literature[J]. J Reprod Med, 2008, 53:465-475. http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_PM18720920
    [19] Ohira S, Yamazaki T, Hatano H, et al. Epithelioid trophoblastic tumor metastatic to the vagina:an immunohisto-chemical and ultrastructural study[J]. Int J Gynecol Pathol, 2000, 19:381-386. doi:  10.1097/00004347-200010000-00015
    [20] Kuo KT, Chen MJ, Lin MC. Epithelioid trophoblastic tumor of the broad ligament:a case report and review of the litera-ture[J]. Am J Surg Pathol, 2004, 28:405-409. doi:  10.1097/00000478-200403000-00017
    [21] Parker A, Lee V, Dalrymple C, et al. Epithelioid tropho-blastic tumour:report of a case in the fallopian tube[J]. Pathology, 2003, 35:136-140. https://www.ncbi.nlm.nih.gov/pubmed/12745461
    [22] Arafah MA, Tulbah AM, Al-Husaini H, et al. Extrauterine epithelioid trophoblastic tumor arising in the ovary with multiple metastases:a case report[J]. Int J Surg Pathol, 2015, 23:339-344. doi:  10.1177/1066896915570661
    [23] Noh HT, Lee KH, Lee MA, et al. Epithelioid trophoblastic tumor of paracervix and parametrium[J]. Int J Gynecol Cancer, 2008, 18:843-846. doi:  10.1111/j.1525-1438.2007.01086.x
    [24] Hsiue EH, Hsu C, Tseng LH, et al. Epithelioid trophoblastic tumor around an abdominal cesarean scar: a pathologic and molecular genetic analysis[J]. Int J Gynecol Pathol, 2017. doi: 10.1097/PGP.0000000000000366[Epubaheadofprint].
    [25] Theodossiadis P, Rouvas A, Nakopoulou L, et al. Epithelioid trophoblastic tumor[J]. Ophthalmology, 2007, 114:1421. doi:  10.1016/j.ophtha.2007.04.002
    [26] Li J, Shi Y, Wan X, et al. Epithelioid trophoblastic tumor:a clinicopathological and immunohistochemical study of seven cases[J]. Med Oncol, 2011, 28:294-299. doi:  10.1007/s12032-010-9419-1
    [27] Chohan MO, Rehman T, Cerilli LA, et al. Metastatic epithelioid trophoblastic tumor involving the spine[J]. Spine(Phila Pa 1976), 2010, 35:E1072-E1075. doi:  10.1097/BRS.0b013e3181d7696b
    [28] Tsai HW, Lin CP, Chou CY, et al. Placental site nodule transformed into a malignant epithelioid trophoblastic tumour with pelvic lymph node and lung metastasis[J]. Histopatho-logy, 2008, 53:601-604. https://pubmed.ncbi.nlm.nih.gov/18983471/
    [29] Lewin SN, Aghajanian C, Moreira AL, et al. Extrauterine epithelioid trophoblastic tumors presenting as primary lung carcinomas:morphologic and immunohistochemical features to resolve a diagnostic dilemma[J]. Am J Surg Pathol, 2009, 33:1809-1814. doi:  10.1097/PAS.0b013e3181b9cd67
    [30] Lurain JR. Gestational trophoblastic disease Ⅱ:classification and management of gestational trophoblastic neoplasia[J]. Am J Obstet Gynecol, 2011, 204:11-18. doi:  10.1016/j.ajog.2010.06.072
    [31] Zhang X, Lu W, Lu B. Epithelioid trophoblastic tumor:an outcome-based literature review of 78 reported cases[J]. Int J Gynecol Cancer, 2013, 23:1334-1338. doi:  10.1097/IGC.0b013e31829ea023
    [32] Shen X, Xiang Y, Guo L, et al. Analysis of clinicopathologic prognostic factors in 9 patients with epithelioid trophoblastic tumor[J]. Int J Gynecol Cancer, 2011, 21:1124-1130. doi:  10.1097/IGC.0b013e31821dc89a
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (214) PDF downloads(188) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return