Volume 7 Issue 6
Nov.  2016
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Xiao-feng LI, Chao-ji ZHANG, Jian-zhou LIU, Guo-tao MA, Xing-rong LIU, Qi MIAO. Correlation Between Blood Transfusion and Postoperative Outcomes following Cardiac Surgery: A Systematic Review[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(6): 426-431. doi: 10.3969/j.issn.1674-9081.2016.06.005
Citation: Xiao-feng LI, Chao-ji ZHANG, Jian-zhou LIU, Guo-tao MA, Xing-rong LIU, Qi MIAO. Correlation Between Blood Transfusion and Postoperative Outcomes following Cardiac Surgery: A Systematic Review[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(6): 426-431. doi: 10.3969/j.issn.1674-9081.2016.06.005

Correlation Between Blood Transfusion and Postoperative Outcomes following Cardiac Surgery: A Systematic Review

doi: 10.3969/j.issn.1674-9081.2016.06.005
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  • Corresponding author: ZHANG Chao-ji Tel: 010-69152820, E-mail:chaojizhang@163.com
  • Received Date: 2015-06-09
  • Publish Date: 2016-11-30
  •   Objective  To systematically assess the correlation between blood transfusion and postoperative outcomes following cardiac surgery.  Methods  Databases were searched for retrospective case-control studies on blood transfusion and postoperative outcome after cardiac surgery published in Chinese and English between January 1990 and December 2014. A meta-analysis was performed using RevMan 5.3 for quantitative synthesis of findings from included studies.  Results  Thirteen retrospective case-control studies including 88 808 patients (42 991 blood transfusion cases, 45 817 non-transfusion cases) were eligible for inclusion. The pooled analysis revealed statistically significant differences in all the postoperative outcomes:30-day mortality (OR=2.39, 95% CI:1.71-3.34, P < 0.000 01), 1-year mortality (OR=3.08, 95% CI:2.18-4.35, P < 0.000 01), 5-year mortality (OR=1.90, 95% CI:1.42-2.56, P < 0.0001), ischemic accident (OR=2.23, 95% CI:1.71-2.90, P < 0.000 01), and infection (OR=2.18, 95% CI:1.74-2.75, P < 0.000 01).  Conclusion  Perioperative blood transfusion may be strongly related with the risk of postoperative short- and long-term mortality, ischemic events, and infection following cardiac surgery.
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