Volume 7 Issue 6
Nov.  2016
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Ya-ping WANG, Rong CHEN, Shou-qing LIN, Jing-lan BAI, Ying JIANG, Ying ZHANG. Change of Uterine Size in Ovarian Aging[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(6): 401-408. doi: 10.3969/j.issn.1674-9081.2016.06.001
Citation: Ya-ping WANG, Rong CHEN, Shou-qing LIN, Jing-lan BAI, Ying JIANG, Ying ZHANG. Change of Uterine Size in Ovarian Aging[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(6): 401-408. doi: 10.3969/j.issn.1674-9081.2016.06.001

Change of Uterine Size in Ovarian Aging

doi: 10.3969/j.issn.1674-9081.2016.06.001
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  • Corresponding author: CHEN Rong Tel: 010-69155012, E-mail:chenrongpumch@163.com
  • Received Date: 2016-10-28
  • Publish Date: 2016-11-30
  •   Objective  To investigate the change of uterine size in ovarian aging in women living in a Beijing community.  Methods  A total of 418 healthy women aged 30 to 68 years who could be staged by STRAW+10 staging system were recruited from a Beijing community and prospectively followed up for 5 years. Menstrual dairy was recorded daily by every woman during the research. Transvaginal ultrasonography was performed for measurement of uterine size at baseline and each year during the 5 years. Serum estradiol (E2) was tested as well.  Results  At baseline, various diameters and volume of uterus began to shrink significantly since the early post-menopausal stage+1a and shrank further at stage+1c (P < 0.05), while not changed much at late post-meno-pausal stage. The thickness of endometrium decreased from stage+1a (P < 0.05) and showed no significant change after that (P>0.05). E2 in menopausal transition and the first 2 years after menopause had a large variation that no significant difference was found comparing with reproductive stage (P>0.05). E2 level decreased significantly at stage+1c(P < 0.05) and kept at a low level at late postmenopausal stage, with no statistically significant difference compared with stage+1c (P>0.05). For women still at the same STRAW+10 stages after 5-year's follow-up, there was only decline in some diameters at early and late postmenopausal stages and no obvious change in endometrial thickness. E2 level only decreased in the late postmenopausal stage(P < 0.01). For women with stage progress after 5-year's follow-up, each line diameter and volume of the uterus changed significantly during transition to early postmenopausal stage +1a/+1b, or from menopausal transition stage to ensuing stages. Change in endometrial thickness was only found in those transformed since menopausal transition stage. E2 level changed mainly after menopausal transition stage. Uterine fibroids increased significantly during the transition from the reproductive stage to the menopausal transition stage (P < 0.01) and began to shrink after menopause but with no statistically significant difference(P>0.05). The decline in uterine volume in women with uterine fibroid was mainly observed at early postmenopausal stage, with no obvious change afterwards.  Conclusions  Uterine size, endometrial thickness, and E2 level do not change in synchronization. Uterine size shrinks during a rather long time since menopause, endometrial thickness begins to reduce mainly in the early stage after menopause. E2 in menopausal transition and the first 2 years after menopause has a big variation which does not decrease obviously until 2 years after menopause.
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