Volume 7 Issue 3
May  2016
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Ya-ping WANG, Rong CHEN, Shou-qing LIN, Jing-lan BAI, Yan-yan FAN, Hui-jun LIN, Ying ZHANG. Changes of Hormone Levels and Ovary Size in Ovarian Aging[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(3): 161-167. doi: 10.3969/j.issn.1674-9081.2016.03.001
Citation: Ya-ping WANG, Rong CHEN, Shou-qing LIN, Jing-lan BAI, Yan-yan FAN, Hui-jun LIN, Ying ZHANG. Changes of Hormone Levels and Ovary Size in Ovarian Aging[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(3): 161-167. doi: 10.3969/j.issn.1674-9081.2016.03.001

Changes of Hormone Levels and Ovary Size in Ovarian Aging

doi: 10.3969/j.issn.1674-9081.2016.03.001
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  • Corresponding author: CHEN Rong  Tel: 010-69155012, E-mail: chenrongpumch@163.com
  • Received Date: 2016-04-12
  • Publish Date: 2016-05-30
  •   Objective  To investigate the changes of serum sex hormone levels and ovary size in ovarian aging in women living in a Beijing community.  Methods  A total of 418 healthy women aged 30 to 68 years who could be staged by STRAW+10 staging system were recruited from a Beijing community and prospectively followed-up for 5 years. Menstrual diary was recorded by every woman during the research. Serum estradiol(E2) and follicle stimulating hormone (FSH) levels were tested at baseline and 5 years later. Pelvic ultrasonography was performed for measurement of ovary size.  Results  According to STRAW+10 stage, E2 began to decrease in early postmenopausal stage, which further decreased in late postmenopausal stage. FSH increased significantly from the beginning of late menopausal transition stage, remaining at a high level after menopause. The length, width, and area of the ovary all reduced after menopause. Hormone levels and ovary size changed with some rules in the 5-year follow-up even when the STRAW+10 stage did not change. In women with staging progressed after 5 years of follow-up, E2 and FSH levels, and length, width, and area of the ovary were significantly different (all P < 0.01) when progressing from early or late menopausal transition stage to early postmenopausal stage. Ovarian no-echo cyst (diameter ≥ 1.4 cm and < 2.5 cm) was the most common in late menopausal transition stage both at baseline and after 5 years, with an incidence of 6.5% and 12.1%, respectively.  Conclusions  When the STRAW+10 stage changes from menopausal transition to early postmenopausal stage, E2 decreases and FSH increases significantly with obvious ovarian atrophy. Reproductive aging has more influence on hormone levels and ovary size than aging does. STRAW+10 staging system could be applied for women in Beijing.
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