Email Alert RSS
Volume 7 Issue 2
Mar.  2016
Turn off MathJax
Article Contents
Abstract
References
Related Articles
Zhong HE, Shou-qing LIN, Rong CHEN, Ying CHEN, Hong-lian GAO, Zheng-lai WU. Menstrual Cyclicity Change in Ovarian Aging[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(2): 81-87. DOI: 10.3969/j.issn.1674-9081.2016.02.001
Citation: Zhong HE, Shou-qing LIN, Rong CHEN, Ying CHEN, Hong-lian GAO, Zheng-lai WU. Menstrual Cyclicity Change in Ovarian Aging[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(2): 81-87. DOI: 10.3969/j.issn.1674-9081.2016.02.001
shu

Menstrual Cyclicity Change in Ovarian Aging

  • 1.

    Continuing Education College, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

  • 4.

    Central Laboratory of Clinical Medicine, Binzhou Medical College, Binzhou, Shandong 256603, China

  • 5.

    Department of Epidemiology & Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China

More Information
  • Corresponding author:

    LIN Shou-qing Tel: 010-69158948, E-mail:shouqing_lin2003@163.com

  • Received Date: January 31, 2016
  • Issue Publish Date: March 29, 2016
    Graphical Abstract
    • Abstract
  •   Objective  To observe the alterations of each menstrual factor in ovarian aging.
      Methods  The data were obtained from one-year observation of a prospective cohort involving 323 healthy women in the age of 30-54 years in a community in Beijing. Menstrual diary was kept and serum level of follicle-stimulating hormone (FSH) was tested. The participants were divided into groups based on age, FSH level, and stages of reproductive aging. Alterations of length of menstrual cycle (LMC), length of menstrual period, and menstrual volume were analyzed in each group.
      Results  Age:the mean LMC extended after the age of 40 years, obviously after 48, and peaked with (67.04±36.77) days in ≥ 52-year-old group. The mean length of menstrual period did not vary much with age. However, the variation of mean length of menstrual period gradually increased with age after 44 years old, peaked in 50- to 51-year-old group. The menstrual volume scores were approximately stable between 38 and 47 years of age, with a peak of(45.06±93.54) in 48- to 49-year-old group and a minimum of (15.87±13.81) in ≥ 52-year-old group. FSH level:LMC increased with elevation of FSH levels. There was no significant difference in the mean length of menstrual period among FSH level groups, but the variation of length of menstrual period was maximum in 20 < FSH ≤ 40 U/L group. The maximum mean menstrual volume score was (30.69±31.84), observed in 10 < FSH ≤ 15 U/L group, while the minimum was (17.38±24.38) in FSH > 40 U/L group. Stages of reproductive aging:the length of menstrual period and menstrual volume scores among each stage showed no statistically significant difference(P > 0.05).
      Conclusions  The LMC altered significantly in ovarian aging, which could be used as staging criteria of reproductive aging. The length of menstrual period and menstrual volume are also showing some characteristic changes, possibly of some clinical values.
    • FullText(HTML)
    • References (16)
  • [1]
    Harlow SD, Mitchell ES, Crawford S, et al.The ReSTAGE Collaboration:defining optimal bleeding criteria for onset of early menopausal transition[J]. Fertil Steril, 2008, 89:129-140. DOI: 10.1016/j.fertnstert.2007.02.015
    [2]
    Harlow SD, Cain K, Crawford S, et al. Evaluation of four proposed bleeding criteria for the onset of late menopausal transition[J]. J Clin Endocrinol Metab, 2006, 91:3432-3438. DOI: 10.1210/jc.2005-2810
    [3]
    Soules MR, Sherman S, Parrott E, et al. Executive summary:Stages of Reproductive Aging Workshop (STRAW)[J]. Fertil Steril, 2001, 76:874-878. DOI: 10.1016/S0015-0282(01)02909-0
    [4]
    Harlow SD, Gass M, Hall JE, et al. Executive summary of the Stages of Reproductive Aging Workshop +10:addressing the unfinished agenda of staging reproductive aging[J]. J Clin Endocrinol Metab, 2012, 97:1159-1168. DOI: 10.1210/jc.2011-3362
    [5]
    Paramsothy P, Harlow SD, Greendale GA, et al. Bleeding patterns during the menopausal transition in the multi-ethnic Study of Women's Health Across the Nation (SWAN):A prospective cohort study[J]. BJOG, 2014, 121:1564-1573. DOI: 10.1111/1471-0528.12768
    [6]
    Mitchell ES, Woods NF, Mariella A.Three stages of the menopausal transition from the Seattle Midlife Women's Health Study:toward a more precise definition[J]. Menopause, 2000, 7:334-349. DOI: 10.1097/00042192-200007050-00008
    [7]
    American College of Obstetricians and Gynecologists. Practice Bulletin Number 136, July 2013:Management of Abnormal Uterine Bleeding Associated with Ovulatory Dysfunction[J]. Obstet Gynecol, 2013, 1222:176-185. http://europepmc.org/abstract/med/23787936
    [8]
    Munro MG, Critchley HO, Fraser IS, et al. The FIGO classification of causes of abnormal uterine bleeding in the reproductive years[J]. Fertil Steril, 2011, 95:2204-2208. DOI: 10.1016/j.fertnstert.2011.03.079
    [9]
    中华医学会妇产科学分会妇科内分泌学组.异常子宫出血诊断与治疗指南[J].中国妇产科杂志, 2014, 49:801-806. http://d.wanfangdata.com.cn/Periodical/zhfck201411001
    [10]
    Higham JM, O'Brien PM, Shaw RW. Assessment of menstrual blood loss using a pictorial chart[J]. Br J Obstet Gynaecol, 1990, 97:734-739. DOI: 10.1111/j.1471-0528.1990.tb16249.x
    [11]
    Treloar AE, Boynton RE, Behn BG, et al. Variation of the human menstrual cycle through reproductive life[J]. Int J Fertil, 1962, 12:77-126. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=WK_LWW2017052520382999
    [12]
    Dudley EC, Hopper JL, Taffe J, et al. Using longitudinal data to define the perimenopause by menstrual cycle characteristics[J]. Climacteric, 1998, 1:18-25. DOI: 10.3109/13697139809080677
    [13]
    Faddy MJ. Follicle dynamics during ovarian ageing[J]. Mol Cell Endocrinol, 2000, 163:43-48. DOI: 10.1016/S0303-7207(99)00238-5
    [14]
    Hansen KR, Knowlton NS, Thyer AC, et al. A new model of reproductive aging:the decline in ovarian non-growing follicle number from birth to menopause[J].Hum Reprod, 2008, 23:699-708. DOI: 10.1093/humrep/dem408
    [15]
    Klein NA, Illingworth PJ, Groome N, et al. Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women:a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles[J]. J Clin Endocrinol Metab, 1996, 81:2742-2745. http://www.ncbi.nlm.nih.gov/pubmed/8675606
    [16]
    Miro F, Parker SW, Aspinall LJ, et al. Sequential classification of endocrine stages during reproductive aging in women:the FREEDOM study[J]. Menopause, 2005, 12:281-290. DOI: 10.1097/01.GME.0000147018.30796.25
    • Related Articles

  • Related Articles

    [1]LIU Yuan, ZHAO Lin. Update and Interpretation of 2022 National Comprehensive Cancer Network Clinical Practice Guidelines for Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 999-1004. DOI: 10.12290/xhyxzz.2022-0271
    [2]GAO Xuehan, DI Xiao, FENG Fengzhi, ZHOU Na, ZHOU Weixun, LI Yuan, ZHU A'fang, HE Lei, QIAO Yi, SUN Mengqing, JIANG Xin, CHEN Yuexin, ZHENG Yuehong. Menstrual Disturbance, Edema of the Lower Limb and Acute Kidney Injury: A Rare Event of "Tumor Embolism" in Malignant Pelvic Tumor[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(4): 693-701. DOI: 10.12290/xhyxzz.2021-0640
    [3]Chinese Menopause Society. Expert Consensus on the Diagnosis and Treatment of Perimenopausal Abnormal Uterine Bleeding[J]. Medical Journal of Peking Union Medical College Hospital, 2018, 9(4): 313-319. DOI: 10.3969/j.issn.1674-9081.2018.04.006
    [4]Hong-lian GAO, Shou-qing LIN, Ying CHEN, Yang WEI, Zheng-lai WU, Ya-ping WANG, Rong CHEN. Impact of Menstrual Status on Musculoskeletal Pain[J]. Medical Journal of Peking Union Medical College Hospital, 2016, 7(4): 241-245. DOI: 10.3969/j.issn.1674-9081.2016.04.001
    [7]Ming-sheng MA, Xü-de ZHANG, Min WEI, Shi-min ZHAO, Zheng-qing QIU. Efficacy of Low Dose Corticosteroid Therapy in Duchenne Muscular Dystrophy[J]. Medical Journal of Peking Union Medical College Hospital, 2014, 5(4): 384-388. DOI: 10.3969/j.issn.1674-9081.2014.04.006
    [9]Jie LIU, Yue-ping ZENG, Chun-xia HE, Qin LONG, Hong-zhong JIN, Qiu-ning SUN. Corticosteroids plus Intravenous Immunoglobulin in the Treatment of 7 Cases with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(4): 381-385. DOI: 10.3969/j.issn.1674-9081.2012.04.004
    [10]Shuai TANG, Jie YI, Yu-guang HUANG. Cardiovascular Responses of Intubation with Shikani Seeing Optical Stylet and Macintosh Laryngoscope[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(3): 314-317. DOI: 10.3969/j.issn.1674-9081.2012.03.015

  • Cited by

    Periodical cited type(2)

    1. 韩洁，冯瑾，张连娜，杨芳. ~(18)F-FDG PET/CT显像对下肢长骨骨折相关性感染的诊断价值. 中国临床医学影像杂志. 2025(03): 209-212 .
    2. 朱世坤，罗亚平. 皮肤黑色素瘤的区域淋巴结评估. 中华核医学与分子影像杂志. 2023(11): 691-693 .

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (238) PDF downloads (6) Cited by(2)
    Related
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

      Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

      /

      DownLoad:  Full-Size Img  PowerPoint
      Return
      Return
      x Close Forever Close